Protection Against Aminoglycoside-induced Ototoxicity by Regulated AAV Vector-mediated GDNF Gene Transfer Into the Cochlea.

Title

Protection Against Aminoglycoside-induced Ototoxicity by Regulated AAV Vector-mediated GDNF Gene Transfer Into the Cochlea.

Creator

Liu Yuhe; Okada Takashi; Shimazaki Kuniko; Sheykholeslami Kianoush; Nomoto Tatsuya; Muramatsu Shin-Ichi; Mizukami Hiroaki; Kume Akihiro; Xiao Shuifang; Ichimura Keiichi; Ozawa Keiya

Publisher

Molecular therapy : the journal of the American Society of Gene Therapy

Date

2008
2008-03

Description

Since standard aminoglycoside treatment progressively causes hearing disturbance with hair cell degeneration, systemic use of the drugs is limited. Adeno-associated virus (AAV)-based vectors have been of great interest because they mediate stable transgene expression in a variety of postmitotic cells with minimal toxicity. In this study, we investigated the effects of regulated

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

URL Address

http://doi.org/10.1038/sj.mt.6300379

Pages

474–480

Issue

3

Volume

16

Citation

Liu Yuhe; Okada Takashi; Shimazaki Kuniko; Sheykholeslami Kianoush; Nomoto Tatsuya; Muramatsu Shin-Ichi; Mizukami Hiroaki; Kume Akihiro; Xiao Shuifang; Ichimura Keiichi; Ozawa Keiya, “Protection Against Aminoglycoside-induced Ototoxicity by Regulated AAV Vector-mediated GDNF Gene Transfer Into the Cochlea.,” NEOMED Bibliography Database, accessed April 26, 2024, https://neomed.omeka.net/items/show/4002.