Waxy keratoses of childhood in a segmental distribution.

Waxy keratoses of childhood in a segmental distribution.

Mehrabi D; Thomas J E; Selim M A; Prose N S

Pediatric dermatology

2001

2001-10

Waxy keratoses of childhood is a rare genodermatosis previously noted in both familial and isolated presentations. Three previous cases have been described in which the lesions appeared over the trunk and extremities. We report a case in which the waxy keratoses of childhood lesions appeared in a segmental distribution along a single lower extremity, differing from the more extensive patterns reported previously. We suggest a possible postzygotic mutation hypothesis for this unique segmental distribution, addressing both the possibility of a genomic mosaicism and loss of heterozygosity.

Child; Diagnosis; Differential; Female; Humans; Keratosis/diagnosis/*genetics/pathology

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415–416

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