A Novel Hybrid-Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S-epidermidis Biofilm Accumulation

Title

A Novel Hybrid-Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S-epidermidis Biofilm Accumulation

Creator

Park B W; Krieger J; Sondag G R; Moussa F M; Rankenberg J; Safadi F F; Gatsonis N A; McGimpsey W G; Lambert C R; Malcuit C

Publisher

Advanced Engineering Materials

Date

2016
2016-04

Description

We provide a comparative analysis of protein adsorption, primary human cell behavior, and biofilm formation on modified titanium substrates of either micro-, nano-, or hybrid micro/nano-scale feature sizes. While studies revealed that nano-scale structures initially decreased the attachment and spreading of both human fibroblasts (hDFs) and mesenchymal stem cells (hMSCs), hMSC differentiation studies revealed that hybrid structures promoted the highest levels of osteogenic gene expression and attenuated biofilm formation by Staphylococcus epidermidis. Taken together, this novel approach of generating a hybrid topographical feature results in a potential implant material capable of enhanced dermal cell adhesion and osteogenic differentiation while limiting biofilm accumulation.

Subject

differentiation; energy; hydrophilicity; implants; in-vitro; Materials Science; nanotopography; osseointegration; osteoactivin; osteoblast lineage cells; responses

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

518-531

Issue

4

Volume

18

Citation

Park B W; Krieger J; Sondag G R; Moussa F M; Rankenberg J; Safadi F F; Gatsonis N A; McGimpsey W G; Lambert C R; Malcuit C, “A Novel Hybrid-Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S-epidermidis Biofilm Accumulation,” NEOMED Bibliography Database, accessed October 21, 2021, https://neomed.omeka.net/items/show/6720.

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