NEUROTROPHIN EXPRESSION IN RAT HIPPOCAMPAL SLICES - A STIMULUS PARADIGM INDUCING LTP IN CA1 EVOKES INCREASES IN BDNF AND NT-3 MESSENGER-RNAS

Title

NEUROTROPHIN EXPRESSION IN RAT HIPPOCAMPAL SLICES - A STIMULUS PARADIGM INDUCING LTP IN CA1 EVOKES INCREASES IN BDNF AND NT-3 MESSENGER-RNAS

Creator

Patterson S L; Grover L M; Schwartzkroin P A; Bothwell M

Publisher

Neuron

Date

1992
1992-12

Description

We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons. No changes in BDNF or NT-3 mRNA levels were seen in the nonstimulated regions of the pyramidal cell layer or the dentate. No change was seen in the levels of NGF mRNA at the time point examined. These results suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus. Given that known effects of NGF (and presumably of BDNF and NT-3) include elevation of neurotransmitter levels, elevation of sodium channels, and promotion of axonal terminal sprouting, activity-associated changes in neurotrophin levels may play a role in regulating neural connections in the adult as well as the developing nervous system.

Subject

alzheimers-disease; choline-acetyltransferase activity; dopamine-beta-hydroxylase; factor family; nerve growth-factor; neuronal death; Neurosciences & Neurology; ngf; protein-kinase; receptor; selective induction; tyrosine-hydroxylase

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1081-1088

Issue

6

Volume

9

Citation

Patterson S L; Grover L M; Schwartzkroin P A; Bothwell M, “NEUROTROPHIN EXPRESSION IN RAT HIPPOCAMPAL SLICES - A STIMULUS PARADIGM INDUCING LTP IN CA1 EVOKES INCREASES IN BDNF AND NT-3 MESSENGER-RNAS,” NEOMED Bibliography Database, accessed October 21, 2021, https://neomed.omeka.net/items/show/6740.

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