Repeated stressor exposure regionally enhances beta-adrenergic receptor-mediated brain IL-1 beta production

Title

Repeated stressor exposure regionally enhances beta-adrenergic receptor-mediated brain IL-1 beta production

Creator

Porterfield V M; Gabella K M; Simmons M A; Johnson J D

Publisher

Brain Behavior and Immunity

Date

2012
2012-11

Description

It has been proposed that increased brain cytokines during repeated stressor exposure can contribute to neuropathological changes that lead to the onset of depression. Previous studies demonstrate that norepinephrine acting via beta-adrenergic receptors (beta-ARs) mediate brain IL-1 production during acute stressor exposure. The aim of the current studies was to examine how the regulation of brain cytokines by adrenergic signaling might change following repeated stressor exposure. Fischer rats were exposed to four days of chronic mild stress and 24 h after the last stressors beta-AR expression, norepinephrine turnover, and beta-AR-mediated induction of brain IL-1 were measured in limbic areas (e.g. hypothalamus, hippocampus, amygdala, and prefrontal cortex) and brainstem. Repeated stressor exposure resulted in decreases in beta-AR expression (B-max) measured by saturation binding curves in many limbic brain areas, while an increase was observed in the brainstem. This coincided with significant increases in norepinephrine turnover in the prefrontal cortex, hypothalamus, and amygdala, a significant increase in norepinephrine turnover was not observed in the hippocampus or brainstem. Stress increased overall IL-1 production in the amygdala (both basal and stimulated). While stress did not affect basal IL-1 levels in any other brain area, central administration of isoproterenol (a beta-AR agonist) augmented IL-1 production in the hypothalamus of stressed animals. These data indicate that repeated stressor exposure results in brain area specific enhancements in beta-AR-mediated IL-1 production and extends current knowledge of stress-induced enhancement of brain cytokine beyond sensitized response to immunological stimuli. (C) 2012 Elsevier Inc. All rights reserved.

Subject

Anhedonia; antidepressant treatments; Chronic mild stress; chronic psychosocial stress; Cytokine; depression; depressive-like behavior; hippocampal neurogenesis; Immunology; inflammatory cytokines; ligand-binding; messenger-rna; Neurosciences & Neurology; Norepinephrine; paraventricular nucleus; prefrontal cortex; Psychiatry; rat; rat-brain; Receptor binding; Sensitization

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1249-1255

Issue

8

Volume

26

Citation

Porterfield V M; Gabella K M; Simmons M A; Johnson J D, “Repeated stressor exposure regionally enhances beta-adrenergic receptor-mediated brain IL-1 beta production,” NEOMED Bibliography Database, accessed April 20, 2021, https://neomed.omeka.net/items/show/6802.

Social Bookmarking