EMERGENCE OF ANTIMICROBIAL RESISTANCE IN GRAM-NEGATIVE BACILLI CAUSING BACTEREMIA DURING THERAPY

Title

EMERGENCE OF ANTIMICROBIAL RESISTANCE IN GRAM-NEGATIVE BACILLI CAUSING BACTEREMIA DURING THERAPY

Creator

Siebert J D; Thomson R B; Tan J S; Gerson L W

Publisher

American Journal of Clinical Pathology

Date

1993
1993-07

Description

Treatment of serious infections caused by gram-negative bacilli with beta-lactam antimicrobial agents can induce Class I beta-lactamase production. This phenomenon can result in resistant microorganisms, and has been postulated to be a cause of therapeutic failure. The charts of patients bacteremic with Pseudomonas aeruginosa, Serratia marcescens, Enterobacter cloacae, Citrobacter freundii, Proteus vulgaris, and Providencia species (n=120) during a 3-year period were reviewed to determine how common the emergence of resistance was, and to determine if in vitro susceptibility testing was a reliable therapeutic guide. Emergence of resistance was believed to occur when a subsequent bacteremic isolate showed at least a fourfold increase in minimum inhibitory concentration accompanied by a change of interpretive susceptibility category. In the group of patients who survived at least 48 hours that received beta-lactam therapy (n=76), one case of emergence of resistance was identified (1.3%). Emergence of resistance to beta-lactam antimicrobial agents did not commonly cause therapeutic failure at our institution, and susceptibility testing of gram-negative bacilli by usual methods was a reliable guide to antimicrobial therapy.

Subject

beta-lactam antibiotics; cephalosporins; enterobacter-cloacae; Pathology

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

47-51

Issue

1

Volume

100

Citation

Siebert J D; Thomson R B; Tan J S; Gerson L W, “EMERGENCE OF ANTIMICROBIAL RESISTANCE IN GRAM-NEGATIVE BACILLI CAUSING BACTEREMIA DURING THERAPY,” NEOMED Bibliography Database, accessed October 9, 2024, https://neomed.omeka.net/items/show/7172.