DOPAMINERGIC MODULATION OF GLUTAMATE RELEASE IN STRIATUM AS MEASURED BY MICRODIALYSIS
Title
DOPAMINERGIC MODULATION OF GLUTAMATE RELEASE IN STRIATUM AS MEASURED BY MICRODIALYSIS
Creator
Yamamoto B K; Davy S
Publisher
Journal of Neurochemistry
Date
1992
1992-05
Description
Glutamate and aspartate are the primary neurotransmitters of projections from motor and premotor cortices to the striatum. Release of glutamate may be modulated by dopamine receptors located on corticostriatal terminals. The present study used microdialysis to investigate the dopaminergic modulation of in vivo striatal glutamate and aspartate release in the striatum of awake-behaving rats. Local perfusion with a depolarizing concentration of K+ through a dialysis probe into the rat striatum produced a significant increase in the release of glutamate, aspartate, and taurine. The D2 agonist LY171555 blocked the K+-induced release of glutamate and aspartate, but not taurine, in a concentration-dependent manner. The D1 agonist SKF 38393 did not alter K+-induced release of glutamate and taurine, but did significantly decrease aspartate release. Neither agonist had any effect on basal amino acid release. The D2 antagonist (-)-sulpiride reversed the inhibitory effects of LY 171555 on K+-induced glutamate release. These results provide in vivo evidence for a functional interaction between dopamine, the D2 receptor, and striatal glutamate release.
Subject
afferents; amino-acid neurotransmitters; aspartate; Biochemistry & Molecular Biology; brain-tissue; corticostriatal path; d2 receptors; dopamine; endogenous glutamate; glutamate; in-vivo; lesion; microdialysis; nerve-terminals; Neurosciences & Neurology; pathway; rat caudate-putamen
Identifier
Format
Journal Article
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1736-1742
Issue
5
Volume
58
Citation
Yamamoto B K; Davy S, “DOPAMINERGIC MODULATION OF GLUTAMATE RELEASE IN STRIATUM AS MEASURED BY MICRODIALYSIS,” NEOMED Bibliography Database, accessed May 10, 2024, https://neomed.omeka.net/items/show/7628.