Glycogen-rich malignant melanomas and glycogen-rich balloon cell malignant melanomas - Frequency and pattern of PAS positivity in primary and metastatic melanomas

Title

Glycogen-rich malignant melanomas and glycogen-rich balloon cell malignant melanomas - Frequency and pattern of PAS positivity in primary and metastatic melanomas

Creator

Nowak M A; Fatteh S M; Campbell T E

Publisher

Archives of Pathology & Laboratory Medicine

Date

1998
1998-04

Description

Objective.-After identifying a metastatic glycogen-rich balloon cell malignant melanoma, originally thought to be a benign clear cell tumor of the lung, we investigated the extent of positive reactions, or "positivity," of malignant melanoma to periodic acid-Schiff (PAS) staining. Methods.-Frequency, intensity, and distribution of PAS positivity was studied in 61 excisional biopsy specimens from 58 patients with malignant melanoma. For comparison, 17 benign nevi from 10 patients were examined. Results.-Positivity for PAS was seen in all cases. All malignant melanomas and benign nevi were characterized by weak, diffuse, diastase-resistant PAS positivity. Additionally, focal or diffuse, strong diastase-sensitive PAS positivity was observed in 9 of 61 melanomas (15%); 7 were metastatic and 2 were primary invasive melanomas. Strong diastase-sensitive PAS positivity was seen in all lesions with 30% or more balloon cell features and only in advanced primary or metastatic lesions. The presence of glycogen was confirmed by transmission electron microscopy. Conclusions.-Cutaneous malignant melanomas have weak, diastase-resistant PAS positivity. Strong diastase-sensitive PAS positivity, consistent with the presence of intracytoplasmic glycogen, is seen in many primary and metastatic melanomas with balloon cell features. Depending on the content of the balloon cells, these melanomas are best categorized as either glycogen-rich malignant melanomas or glycogen-rich balloon cell malignant melanomas. Because many tumors with clear cell features contain glycogen, such content often is an unreliable differential feature.

Subject

carcinoma; lung; Medical Laboratory Technology; Pathology; Research & Experimental Medicine; soft parts; sugar tumor

Identifier

n/a

Format

Journal Article

URL Address

n/a

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

353-360

Issue

4

Volume

122

Citation

Nowak M A; Fatteh S M; Campbell T E, “Glycogen-rich malignant melanomas and glycogen-rich balloon cell malignant melanomas - Frequency and pattern of PAS positivity in primary and metastatic melanomas,” NEOMED Bibliography Database, accessed August 19, 2022, https://neomed.omeka.net/items/show/7717.

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