SEROLOGIC REACTIVITY AGAINST MYCOBACTERIUM-PARATUBERCULOSIS ANTIGENS IN PATIENTS WITH SARCOIDOSIS

Title

SEROLOGIC REACTIVITY AGAINST MYCOBACTERIUM-PARATUBERCULOSIS ANTIGENS IN PATIENTS WITH SARCOIDOSIS

Creator

Reid J D; Chiodini R J

Publisher

Sarcoidosis

Date

1993
1993-03

Description

Although sarcoidosis has clinical and histopathologic similarities to some forms of tuberculosis and other mycobacterial infections, attempts to establish a mycobacterial etiology have not been successful. Using cytoplasmic antigens derived from a wild strain of Mycobacterium paratuberculosis in an enzyme-linked immunosorbent assay, patients with sarcoidosis were found to have immunoglobulin levels significantly higher than those found in a control population in the IgG, but not in IgA or IgM antibody classes. Results were comparable to those reported from patients with Crohn's disease, where M. paratuberculosis has been intensively studied as a possible etiologic agent. To elucidate these relationships, examination of DNA from sarcoid tissues for possible homology with DNA from M. paratuberculosis and closely related organisms, as well as cultural attempts with techniques and media appropriate for M. paratuberculosis may be warranted.

Subject

antibodies; crohns-disease; crohns-disease; elisa; elisa assay; inflammatory bowel disease; linked immunosorbent-assay; mycobacterium-paratuberculosis; Respiratory System; tuberculosis

Identifier

n/a

Format

Journal Article

URL Address

n/a

Search for Full-text

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

32-35

Issue

1

Volume

10

Citation

Reid J D; Chiodini R J, “SEROLOGIC REACTIVITY AGAINST MYCOBACTERIUM-PARATUBERCULOSIS ANTIGENS IN PATIENTS WITH SARCOIDOSIS,” NEOMED Bibliography Database, accessed October 22, 2021, https://neomed.omeka.net/items/show/7868.

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