Expression of integrins during axolotl limb regeneration

Expression of integrins during axolotl limb regeneration

Tsonis P A; Doane K; DelRioTsonis K

Development Growth & Differentiation

1997

1997-02

Limb regeneration in urodeles is achieved through the dedifferentiation of tissues at the amputation plane and through the production of the blastema. This tissue breakdown is possible by extensive alterations in molecules of the extracellular matrix. In this respect we describe the regulation of several integrins during such events. It was found that alpha 1 and beta 1 integrins were down-regulated as blastema formation proceeded. In contrast, the expression of alpha 3, alpha 6 and alpha v integrins were upregulated in the blastema. These data are consistent with the roles of integrins in developmental phenomena and are discussed in light of the mechanisms of dedifferentiation.

cell adhesion; Cell Biology; dedifferentiation; Developmental Biology; lens regeneration; limb regeneration; urodeles

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Journal Article

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