Expression of integrins during axolotl limb regeneration

Title

Expression of integrins during axolotl limb regeneration

Creator

Tsonis P A; Doane K; DelRioTsonis K

Publisher

Development Growth & Differentiation

Date

1997
1997-02

Description

Limb regeneration in urodeles is achieved through the dedifferentiation of tissues at the amputation plane and through the production of the blastema. This tissue breakdown is possible by extensive alterations in molecules of the extracellular matrix. In this respect we describe the regulation of several integrins during such events. It was found that alpha 1 and beta 1 integrins were down-regulated as blastema formation proceeded. In contrast, the expression of alpha 3, alpha 6 and alpha v integrins were upregulated in the blastema. These data are consistent with the roles of integrins in developmental phenomena and are discussed in light of the mechanisms of dedifferentiation.

Subject

cell adhesion; Cell Biology; dedifferentiation; Developmental Biology; lens regeneration; limb regeneration; urodeles

Identifier

n/a

Format

Journal Article

URL Address

n/a

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

9-14

Issue

1

Volume

39

Citation

Tsonis P A; Doane K; DelRioTsonis K, “Expression of integrins during axolotl limb regeneration,” NEOMED Bibliography Database, accessed September 28, 2021, https://neomed.omeka.net/items/show/8212.

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