Neuropathological findings in West Nile virus encephalitis: A case report

Title

Neuropathological findings in West Nile virus encephalitis: A case report

Creator

Agamanolis D P; Leslie M J; Caveny E A; Guarner J; Shieh W J; Zaki S R

Publisher

Annals of Neurology

Date

2003
2003-10

Description

A 67-year-old woman had fever, myalgias, progressive weakness, and respiratory insufficiency. In 9 days, flaccid areflexic quadriparesis and bulbar palsy developed. She died 26 days after the onset of her illness. Serum and cerebrospinal fluid serology were positive for West Nile virus. Neuropathological study showed changes consistent with a viral encephalomyelitis, similar to poliomyelitis. The brainstem showed neuronal loss and multiple foci of necrosis. The spinal cord showed severe loss of anterior and posterior horn neurons. Immunohistochemistry identified West Nile virus antigens in the brainstem and spinal cord. Paralysis, in West Nile virus encephalitis, is caused by destruction of motor neurons.

Subject

fever; infection; myelitis; Neurosciences & Neurology; New York; outbreak; Pathology

Identifier

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

547-551

Issue

4

Volume

54

Citation

Agamanolis D P; Leslie M J; Caveny E A; Guarner J; Shieh W J; Zaki S R, “Neuropathological findings in West Nile virus encephalitis: A case report,” NEOMED Bibliography Database, accessed October 23, 2021, https://neomed.omeka.net/items/show/8425.

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