CASE-REPORT - METOLAZONE-ASSOCIATED HYPERCALCEMIA AND ACUTE-PANCREATITIS

CASE-REPORT - METOLAZONE-ASSOCIATED HYPERCALCEMIA AND ACUTE-PANCREATITIS

Anderson P E; Ellis G G; Austin S M

American Journal of the Medical Sciences

1991

1991-10

Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure. Her symptoms and laboratory abnormalities rapidly resolved upon discontinuation of metolazone. Both clinical and laboratory findings make other etiologies for the patient's pancreatitis extremely unlikely. The pathophysiology of thiazide-related hypercalcemia and pancreatitis is reviewed. To our knowledge, neither hypercalcemia nor the combination of acute pancreatitis with hypercalcemia has been reported previously in association with metolazone therapy, and the association of pancreatitis and metolazone has been noted previously only once.

calcium; diuretics; General & Internal Medicine; hydrochlorothiazide; hypercalcemia; mechanism; metolazone; pancreatitis; parathyroid-hormone; serum; thiazide

Journal Article or Conference Abstract Publication

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