Evaluation of Breast Lesions Using Sonographic Elasticity Imaging A Multicenter Trial

Title

Evaluation of Breast Lesions Using Sonographic Elasticity Imaging A Multicenter Trial

Creator

Barr R G; Destounis S; Lackey L B; Svensson W E; Balleyguier C; Smith C

Publisher

Journal of Ultrasound in Medicine

Date

2012
2012-02

Description

Objectives-The purpose of this study was to determine the sensitivity and specificity of real-time compression elasticity imaging in characterizing breast lesions as benign or malignant. Methods-A cohort of 578 women scheduled for sonographically guided biopsy of breast lesions were recruited from 6 sites under an Institutional Review Board-approved protocol. All participants received an elastogram, which displayed both the B-mode and elasticity images in real time. The longest dimensions of the lesion on the B-mode and elasticity imaging were measured. An elasticity imaging/B-mode ratio of at least 1.0 was considered positive for malignant lesions. The reference standard was based on biopsy. Results-A total of 635 lesions were imaged and biopsied. There were 222 (35%) malignant or borderline lesions and 413 (65%) benign lesions. The benign lesions were either cystic (145 [35%]) or solid (268 [65%]). Of the 222 malignant lesions, 219 had an elasticity imaging/B-mode ratio of at least 1.0. Of the 413 benign lesions, 361 had an elasticity imaging/B-mode ratio less than 1.0. These results corresponded to overall sensitivity of 98.6% and overall specificity of 87.4%. Individual site sensitivities ranged from 96.7% to 100% whereas specificities ranged from 66.7% to 95.4%. Conclusions-Elasticity imaging has high sensitivity in characterizing malignant lesions of the breast. Variability in specificity between sites and sonographers is possibly due to individual technique differences in performing elastography and measuring lesions. Further work in standardizing the technique is required.

Subject

ultrasound; breast; elastography; Acoustics; sonoelastography; Radiology; Nuclear Medicine & Medical Imaging; tissues; benign; biopsy; breast lesion characterization

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

281-287

Issue

2

Volume

31

Citation

Barr R G; Destounis S; Lackey L B; Svensson W E; Balleyguier C; Smith C, “Evaluation of Breast Lesions Using Sonographic Elasticity Imaging A Multicenter Trial,” NEOMED Bibliography Database, accessed October 22, 2021, https://neomed.omeka.net/items/show/8571.

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