Lung edema clearance: 20 years of progress - Invited review: Alveolar edema fluid clearance in the injured lung

Title

Lung edema clearance: 20 years of progress - Invited review: Alveolar edema fluid clearance in the injured lung

Creator

Berthiaume Y; Folkesson H G; Matthay M A

Publisher

Journal of Applied Physiology

Date

2002
2002-12

Description

Resolution of pulmonary edema involved active transepithelial sodium transport. Although several of the cellular and molecular mechanisms involved are relatively well understood, it is only recently that the regulation of these mechanisms in injured lung are being evaluated. Interestingly, in mild-to-moderate lung injury, alveolar edema fluid clearance is often preserved. This preserved or enhanced alveolar fluid clearance is mediated by catecholamine-dependent or -independent mechanisms. This stimulation of alveolar liquid clearance is related to activation or increased expression of sodium transport molecules such as the epithelial sodium channel or the Na+-K+-ATPase pump and may also involve the cystic fibrosis transmembrane conductance regulator. When severe lung injury occurs, the decrease in alveolar liquid clearance may be related to changes in alveolar permeability or to changes in activity or expression of sodium or chloride transport molecules. Multiple pharmacological tools such as beta-adrenergic agonists, vasoactive drugs, or gene therapy may prove effective in stimulating the resolution of alveolar edema in the injured lung.

Subject

therapy; liquid clearance; Physiology; pulmonary-edema; Sport Sciences; sodium transport; agonist; epithelial; active sodium-transport; alveolar fluid clearance; barrier function; agonists; respiratory-distress syndrome; na-k-atpase; adenovirus-mediated transfer; beta-adrenergic; beta(1) subunit gene; lung injury; rat lungs

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

2207-2213

Issue

6

Volume

93

Citation

Berthiaume Y; Folkesson H G; Matthay M A, “Lung edema clearance: 20 years of progress - Invited review: Alveolar edema fluid clearance in the injured lung,” NEOMED Bibliography Database, accessed February 28, 2021, https://neomed.omeka.net/items/show/8628.

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