In-hospital levels of C-reactive protein and IL-6 predict post-operative depressive symptoms among patients undergoing total knee replacement surgery

Title

In-hospital levels of C-reactive protein and IL-6 predict post-operative depressive symptoms among patients undergoing total knee replacement surgery

Creator

Cremeans-Smith J K; Soehlen S; Greene K; Alexander T; Delahanty D L

Publisher

Brain Behavior and Immunity

Date

2009
2009-11

Description

Behavioral changes observed following immune system activation are similar to many of the hallmark symptoms of major depressive disorder (MDD), including appetite change, lethargy, fatigue, negative mood and anhedonia. Acute phase proteins, such as interleukin-6 (IL-6) and C-reactive protein (CRP) have been implicated in the production of sickness behavior, and research has revealed significant differences in the levels of these acute phase proteins between depressed and non-depressed individuals. The current study examined whether early post-operative IL-6 and CRP levels predicted subsequent depressive symptoms in 110 patients undergoing total knee replacement surgery (TKR). In-hospital levels of IL-6 and CRP predicted depressive symptoms at three-months following surgery, as indicated by significant main effects and a significant interaction term. Specifically, lower levels of in-hospital CRP and higher levels of IL-6 in-hospital predicted more depressive symptoms three-months following surgery. The finding that levels of acute phase proteins soon after surgery predict subsequent depressive symptoms, if replicated, extends prior research on the relationships between IL-6, CRP, and depression. Further, this predictive relationship suggests the possibility of early identification of individuals at risk for the subsequent development of post-operative depression. (C) 2009 Elsevier Inc. All rights reserved.

Subject

stress; Psychiatry; inflammation; arthroplasty; Neurosciences & Neurology; Immunology; major depression; symptoms; markers; total hip-replacement; coronary-heart-disease; Acute phase proteins; Acute phase proteins; C-reactive protein; Depressive; Interleukin-6; mood; Post-operative outcomes; serum interleukin-6; Total knee replacement surgery

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1096-1103

Issue

8

Volume

23

Citation

Cremeans-Smith J K; Soehlen S; Greene K; Alexander T; Delahanty D L, “In-hospital levels of C-reactive protein and IL-6 predict post-operative depressive symptoms among patients undergoing total knee replacement surgery,” NEOMED Bibliography Database, accessed January 21, 2021, https://neomed.omeka.net/items/show/8994.

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