Lung epithelial fluid transport and the resolution of pulmonary edema

Title

Lung epithelial fluid transport and the resolution of pulmonary edema

Creator

Matthay M A; Folkesson H G; Clerici C

Publisher

Physiological Reviews

Date

2002
2002-07

Description

The discovery of mechanisms that regulate salt and water transport by the alveolar and distal airway epithelium of the lung has generated new insights into the regulation of lung fluid balance under both normal and pathological conditions. There is convincing evidence that active sodium and chloride transporters are expressed in the distal lung epithelium and are responsible for the ability of the lung to remove alveolar fluid at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Currently, the best described molecular transporters are the epithelial sodium channel, the cystic fibrosis transmembrane conductance regulator, Na+-K+-ATPase, and several aquaporin water channels. Both catecholamine-dependent and -independent mechanisms can upregulate isosmolar fluid transport across the distal lung epithelium. Experimental and clinical studies have made it possible to examine the role of these transporters in the resolution of pulmonary edema.

Subject

Physiology; sodium transport; tumor-necrosis-factor; alveolar liquid clearance; respiratory-distress syndrome; adenovirus-mediated transfer; active; aquaporin water channels; beta-adrenergic receptors; pseudomonas-aeruginosa pneumonia; sensitive na+ channel; surface fluorescence method

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

569-600

Issue

3

Volume

82

Citation

Matthay M A; Folkesson H G; Clerici C, “Lung epithelial fluid transport and the resolution of pulmonary edema,” NEOMED Bibliography Database, accessed August 6, 2021, https://neomed.omeka.net/items/show/9042.

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