Synthesis, Permeability And Biocompatibility Of Tricomponent Membranes Containing Polyethylene Glycol, Polydimethylsiloxane And Polypentamethylcyclopentasiloxane Domains

Title

Synthesis, Permeability And Biocompatibility Of Tricomponent Membranes Containing Polyethylene Glycol, Polydimethylsiloxane And Polypentamethylcyclopentasiloxane Domains

Creator

Kurian P; Kasibhatla B; Daum J; Burns C A; Moosa M; Rosenthal K S; Kennedy J P

Publisher

Biomaterials

Date

2003
2003-09

Description

The synthesis of "smart" tricomponent amphiphilic membranes containing poly(ethylene glycol) (PEG), polydimethylsiloxane (PDMS) and polypentamethylcyclopentasiloxane (PD(5)) domains is described. Contact angle hysteresis indicates that in air, the surfaces of such PEG/PD(5)/PDMS membranes are enriched by the hydrophobic components, PDMS and PD(5), while in water, the surfaces are rich in the hydrophilic PEG. The oxygen permeability of a series of membranes with varying M(c,hydrophilic) (M(n,PEG) = 4600, 10,000 and 20,000 g/mol) and varying PEG/PD(5)/PDMS compositions was studied. Oxygen permeability increased with the amount of PDMS in the membrane. The molecular weight cut-off (MWCO) ranges and permeability coefficients of insulin through a series of PEG/PD(5)/PDMS(=29/14/57) membranes with varying M(c,hydrophilic) were determined. Insulin permeability is directly related to Mc,hydrophilic of the membrane. MWCO studies show that the membranes are semipermeable to, i.e., allow the transport of smaller proteins such as insulin (M(n) = 5733 g/mol, R(s) = 1.34 nm) and cytochrome c (M(n) = 12,400 g/mol, R(s) = 1.63 nm), but are barriers to larger proteins such as albumin (M(n) = 66,000 g/mol, R(s) = 3.62 nm). Implantation of representative membranes in rats showed them to be biocompatible. According to these studies, PEG/PD(5)/PDMS membranes may be suitable for biological applications, e.g., immunoisolation of cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

Subject

biocompatibility; compatibility; delivery; Engineering; hydrogels; insulin diffusion; Materials Science; membrane; molecular weight cut-off; networks; oxygen diffusion; star; surface-properties; water

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

3493-3503

Issue

20

Volume

24

Citation

Kurian P; Kasibhatla B; Daum J; Burns C A; Moosa M; Rosenthal K S; Kennedy J P, “Synthesis, Permeability And Biocompatibility Of Tricomponent Membranes Containing Polyethylene Glycol, Polydimethylsiloxane And Polypentamethylcyclopentasiloxane Domains,” NEOMED Bibliography Database, accessed January 27, 2021, https://neomed.omeka.net/items/show/10604.

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