Antibiotics and adverse events: the role of antimicrobial stewardship programs in 'doing no harm'

Title

Antibiotics and adverse events: the role of antimicrobial stewardship programs in 'doing no harm'

Creator

Bauer Karri A; Kullar Ravina; Gilchrist Mark; File Thomas M

Publisher

Current Opinion In Infectious Diseases

Date

2019
2019-12

Description

PURPOSE OF REVIEW: Antimicrobial resistance (AMR) is a global threat worldwide, with deaths associated with AMR infections projected to exceed 10 million per year by the year 2050. The overuse and misuse of antibiotics is the primary driver of this resistance, with up to 50% of antibiotics prescribed in the hospital setting being either unnecessary or inappropriate. Antimicrobial stewardship (AMS) programs (ASPs) can mitigate some of this resistance, with the benefits well recognized; however, if we are to truly advance the state of AMS, the principles and practices should align with patient safety. RECENT FINDINGS: In a recent evaluation, among 1488 adult patients receiving systemic antibiotic therapy, 298 (20%) experienced at least one antibiotic-associated adverse drug event (ADE). Fifty-six (20%) nonclinically indicated antibiotic regimens were associated with an ADE. It is also well recognized that besides ADEs, the inappropriate use of antibiotics is associated the development of multidrug-resistant infections and Clostridium difficile infection. SUMMARY: Currently, there is a significant gap in ASPs correlating initiatives with patient safety goals, including reductions in antibiotic-associated ADEs and multidrug-resistant infections. Therefore, in this article, we provide the rationale for why ASPs are best suited to lead a collaborative effort to prevent antibiotic-associated ADEs and multidrug-resistant infections.

Identifier

PMID: 31567566

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

553-558

Issue

6

Volume

32

ISSN

1473-6527

Citation

Bauer Karri A; Kullar Ravina; Gilchrist Mark; File Thomas M, “Antibiotics and adverse events: the role of antimicrobial stewardship programs in 'doing no harm',” NEOMED Bibliography Database, accessed January 28, 2021, https://neomed.omeka.net/items/show/10808.

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