Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats

Title

Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats

Creator

Mittal N; Fleming S M; Martinez A; Thakore N; Bell R L; Maddox W T; Schallert T; Duvauchelle C L

Publisher

Behavioural Brain Research

Date

2019
2019-12-28

Description

Excessive alcohol (ethanol) consumption negatively impacts social, emotional, as well as cognitive function and well-being. Thus, identifying behavioral and/or biological predictors of excessive ethanol consumption is important for developing prevention and treatment strategies against alcohol use disorders (AUDs). Sex differences in alcohol consumption patterns are observed in humans, primates, and rodents. Selectively bred high alcohol-drinking rat lines, such as the "HAD-1" lines are recognized animal models of alcoholism. The present work examined sex differences in alcohol consumption, object recognition, and exploratory behavior in male and female HAD-1 rats. Naïve male and female HAD-1 rats were tested in an object recognition test (ORT) prior to a chronic 24 h intermittent ethanol access procedure for five weeks. Object recognition parameters measured included exploratory behavior, object investigation, and time spent near objects. During the initial training trial, rearing, active object investigation and amount of time spent in the object-containing section was significantly greater in female HAD-1 rats compared to their male counterparts. During the subsequent testing trial, time spent in the object-containing section was greater in female, compared to male, rats; but active object investigation and rearing did not statistically differ between females and males. In addition, female HAD-1 rats consumed significantly more ethanol than their male counterparts, replicating previous findings. Moreover, across all animals there was a significant positive correlation between exploratory behavior in ORT and ethanol consumption level. These results indicate there are significant sex differences in cognitive performance and alcohol consumption in HAD-1 rats, which suggests neurobiological differences as well.

Subject

Alcohol use disorders; Attention; Exploratory behavior; Novel object recognition; Object recognition test; Selectively bred high alcohol-drinking rats

Identifier

PMID: 31891743

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

112456

Volume

381

ISSN

1872-7549

NEOMED College

NEOMED College of Pharmacy

NEOMED Department

Department of Pharmaceutical Sciences

Update Year & Number

January 2020 Update

Citation

Mittal N; Fleming S M; Martinez A; Thakore N; Bell R L; Maddox W T; Schallert T; Duvauchelle C L, “Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats,” NEOMED Bibliography Database, accessed January 21, 2021, https://neomed.omeka.net/items/show/10938.

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