Evaluating the impact of glucagon-like peptide-1 receptor agonists on metabolic changes in patients with type 2 diabetes on high-dose insulin.
Title
Evaluating the impact of glucagon-like peptide-1 receptor agonists on metabolic changes in patients with type 2 diabetes on high-dose insulin.
Creator
Rentsch T; Awad M; Moorman JM; Gothard MD
Publisher
American Journal of Therapeutics
Date
2020
2020-12-29
Description
BACKGROUND: Studies involving the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide have shown reductions in hemoglobin A1c (HbA1c), weight, and insulin requirements in patients with type 2 diabetes mellitus (DM2) requiring high-dose insulin therapy. The effect of the class of GLP-1 RAs on these parameters is unknown. DATA SOURCES: A retrospective cohort analysis was conducted in patients with DM2 where a GLP-1 RA was added to high-dose insulin therapy. The primary composite outcome was the change from baseline to 9 months in HbA1c, weight, and insulin dose. RESULTS: GLP-1 RA therapy was associated with a significant reduction in HbA1c from baseline (-0.9%; P = 0.022). Weight and insulin dose were not significantly reduced from baseline. There was a moderate effect of individual agents on these outcomes, but no significant reductions were seen due to the small sample size. LIMITATIONS: Generalizability of these findings may be limited by the characteristics and size of the study population. THERAPEUTIC OPINION: The effect of GLP-1 RA therapy on HbA1c may be attributed to the medication class. The effect of individual agents on weight and insulin requirements needs further investigation.
Identifier
Rights
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Format
journalArticle
URL Address
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Volume
Publish Ahead of Print
ISSN
1536-3686 1075-2765
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmacy Practice
Update Year & Number
January 2021 List
Citation
Rentsch T; Awad M; Moorman JM; Gothard MD, “Evaluating the impact of glucagon-like peptide-1 receptor agonists on metabolic changes in patients with type 2 diabetes on high-dose insulin.,” NEOMED Bibliography Database, accessed April 22, 2025, https://neomed.omeka.net/items/show/11500.