Micro-RNA Regulation of Vascular Smooth Muscle Cells and Its Significance in Cardiovascular Diseases.

Title

Micro-RNA Regulation of Vascular Smooth Muscle Cells and Its Significance in Cardiovascular Diseases.

Creator

Nguyen DND;Chilian WM;Zain SM;Daud MF;Pung YF

Publisher

Canadian Journal Of Physiology And Pharmacology

Date

2021
2021-02-02

Description

Cardiovascular disease (CVD) is among the leading causes of death worldwide. MicroRNAs (miRNAs), regulatory molecules that repress protein expression, have attracted considerable attention in CVD research. The vasculature plays a big role in CVD development and progression and dysregulation of vascular cells underlies the root of many vascular diseases. This review provides a brief introduction of the biogenesis of miRNAs and exosomes, followed by overview of the regulatory mechanisms of miRNAs in vascular smooth muscle cells (VSMCs) intracellular signaling during phenotypic switching, senescence, calcification, and neointimal hyperplasia. Evidence of extracellular signaling of VSMCs and other cells via exosomal and circulating miRNAs is also presented. Lastly, current drawbacks and limitations of miRNA studies in CVD research and potential ways to overcome these disadvantages are discussed in detail. In-depth understanding of VSMC regulation via miRNAs will add substantial knowledge and advance research in diagnosis, disease progression, and (or) miRNA-derived therapeutic approaches in CVD research.

Subject

Cardiovascular disease (CVD) refers to conditions affecting the heart and blood vessels in humans and is among the leading causes of death worldwide (World Health Organization 2017). Recently, microRNAs (miRNAs) have attracted considerable attention in CVD research. MiRNAs are regulatory RNA molecules that play a major role in post-transcriptional modification, which regulate gene expression via gene silencing pathways. Unique miRNA expression profiles have been identified in different tissues, suggesting the potential use of miRNAs as specific biomarkers for diagnosis of pathological tissues. Furthermore, accumulating evidence has suggested that miRNAs could be secreted to the extracellular matrix (ECM) or bloodstream to facilitate intercellular communication (Creemers et al. 2012; Kapustin and Shanahan 2016; Kapustin et al. 2015, 2017; X. Lin et al. 2016; Théry et al. 2006; Zheng et al. 2017).

Format

Journal Article

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

Jan to Aug list 2021

Citation

Nguyen DND;Chilian WM;Zain SM;Daud MF;Pung YF, “Micro-RNA Regulation of Vascular Smooth Muscle Cells and Its Significance in Cardiovascular Diseases.,” NEOMED Bibliography Database, accessed May 28, 2024, https://neomed.omeka.net/items/show/11875.