Osteopathy in Complex Lymphatic Anomalies

Osteopathy in Complex Lymphatic Anomalies

Ernesto Solorzano

Andrew L Alejo

Hope C Ball

Joseph Magoline

Yusuf Khalil

Michael Kelly

Fayez F Safadi

2022

Complex Lymphatic Anomalies (CLA) are lymphatic malformations with idiopathic bone and soft tissue involvement. The extent of the abnormal lymphatic presentation and boney invasion varies between subtypes of CLA. The etiology of these diseases has proven to be extremely elusive due to their rarity and irregular progression. In this review, we compiled literature on each of the four primary CLA subtypes and discuss their clinical presentation, lymphatic invasion, osseous profile, and regulatory pathways associated with abnormal bone loss caused by the lymphatic invasion. We highlight key proliferation and differentiation pathways shared between lymphatics and bone and how these systems may interact with each other to stimulate lymphangiogenesis and cause bone loss.

Int J Mol Sci
. 2022 Jul 26;23(15):8258. doi: 10.3390/ijms23158258.

English

https://doi.org/10.3390/ijms23158258