Psychopharmacology in the Elderly: Why Does Age Matter?

Psychopharmacology in the Elderly: Why Does Age Matter?

Kripa Balaram

2022

A growing percentage of the population is aging, with a large subset of this group meeting criteria for one or more neuropsychiatric disorders. Generally, physiological changes due to aging affect most of the pharmacokinetic processes in the body, with age-related physiologic changes in cardiovascular, gastric, hepatic, and renal function leading to changes in the pharmacokinetics of medications that can affect the absorption, distribution, accumulation, and clearance and elimination of various medications. This article aims to discuss the common pharmacodynamic and pharmacokinetic changes associated with physiologic aging and their impacts on the use of psychotropic medications in the elderly.

Psychiatr Clin North Am
. 2022 Dec;45(4):735-744. doi: 10.1016/j.psc.2022.07.004. Epub 2022 Oct 14.

English

https://doi.org/10.1016/j.psc.2022.07.004