Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus

Title

Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus

Creator

Hui Ching Low
William M Chilian
Wickneswari Ratnam
Tilakavati Karupaiah
Mohd Fairulnizal Md Noh
Fazliana Mansor
Zhi Xiang Ng
Yuh Fen Pung

Date

2023

Description

Type 2 Diabetes Mellitus is a major chronic metabolic disorder in public health. Due to mitochondria's indispensable role in the body, its dysfunction has been implicated in the development and progression of multiple diseases, including Type 2 Diabetes mellitus. Thus, factors that can regulate mitochondrial function, like mtDNA methylation, are of significant interest in managing T2DM. In this paper, the overview of epigenetics and the mechanism of nuclear and mitochondrial DNA methylation were briefly discussed, followed by other mitochondrial epigenetics. Subsequently, the association between mtDNA methylation with T2DM and the challenges of mtDNA methylation studies were also reviewed. This review will aid in understanding the impact of mtDNA methylation on T2DM and future advancements in T2DM treatment.

Source

Br J Biomed Sci
. 2023 Feb 14;80:10884. doi: 10.3389/bjbs.2023.10884. eCollection 2023.

Language

English

Citation

Hui Ching Low et al., “Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus,” NEOMED Bibliography Database, accessed May 2, 2024, https://neomed.omeka.net/items/show/12245.