Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus
Title
Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus
Creator
Hui Ching Low
William M Chilian
Wickneswari Ratnam
Tilakavati Karupaiah
Mohd Fairulnizal Md Noh
Fazliana Mansor
Zhi Xiang Ng
Yuh Fen Pung
Date
2023
Description
Type 2 Diabetes Mellitus is a major chronic metabolic disorder in public health. Due to mitochondria's indispensable role in the body, its dysfunction has been implicated in the development and progression of multiple diseases, including Type 2 Diabetes mellitus. Thus, factors that can regulate mitochondrial function, like mtDNA methylation, are of significant interest in managing T2DM. In this paper, the overview of epigenetics and the mechanism of nuclear and mitochondrial DNA methylation were briefly discussed, followed by other mitochondrial epigenetics. Subsequently, the association between mtDNA methylation with T2DM and the challenges of mtDNA methylation studies were also reviewed. This review will aid in understanding the impact of mtDNA methylation on T2DM and future advancements in T2DM treatment.
Source
Br J Biomed Sci
. 2023 Feb 14;80:10884. doi: 10.3389/bjbs.2023.10884. eCollection 2023.
. 2023 Feb 14;80:10884. doi: 10.3389/bjbs.2023.10884. eCollection 2023.
Language
English
URL
https://doi.org/10.3389/bjbs.2023.10884
Citation
Hui Ching Low et al., “Changes in Mitochondrial Epigenome in Type 2 Diabetes Mellitus,” NEOMED Bibliography Database, accessed May 2, 2024, https://neomed.omeka.net/items/show/12245.