Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

Title

Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

Creator

Meehan S M; Schechter M D

Publisher

Progress in neuro-psychopharmacology & biological psychiatry

Date

1994
1994-05

Description

The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain serotonergic levels or function remains unclear, numerous behavioral studies have indicated that FH rats exhibit differential responses to serotonergic agonists and antagonist relative to other strains. The current study used the conditioned place preference paradigm to examine the ability of fenfluramine to produce a conditioned place preference (CPP) or aversion (CPA) in FH and Sprague-Dawley (SD) rats. Results indicated that fenfluramine failed to produce CPP or CPA in SD rats, but did produce a CPA in FH rats. Results are discussed in terms of the use of conditioned place preference to assess putative differences in serotonergic functioning in FH rats.

Subject

Animals; Avoidance Learning/*drug effects; Blood Platelets/metabolism; Brain Chemistry/genetics; Fenfluramine/*pharmacology; Habituation; Inbred Strains; Platelet Storage Pool Deficiency/physiopathology; Psychophysiologic/drug effects; Rats; Serotonin/metabolism/physiology; Species Specificity; Sprague-Dawley

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

575–584

Issue

3

Volume

18

Citation

Meehan S M; Schechter M D, “Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.,” NEOMED Bibliography Database, accessed April 21, 2021, https://neomed.omeka.net/items/show/3360.

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