The potential of tissue engineering in orthopedics.
Title
The potential of tissue engineering in orthopedics.
Creator
Landis William J; Jacquet Robin; Hillyer Jennifer; Zhang Jean; Siperko Lorraine; Chubinskaya Susan; Asamura Shinichi; Isogai Noritaka
Publisher
The Orthopedic clinics of North America
Date
2005
2005-01
Description
This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The cell-polymer constructs are vascularized by the host mice, form new bone, cartilage, and tendon with characteristic gene expression and protein synthesis and secretion, and maintain the shape of human phalanges with joints. The study demonstrates critical progress in the design and fabrication of bone, cartilage, and tendon by tissue engineering and the potential of this field for human clinical orthopedic applications.
Subject
*Artificial Limbs; *Bioprosthesis; *Orthopedics; Animals; Cartilage/growth & development; Finger Joint/growth & development; Fingers/growth & development; Humans; Mice; Periosteum/growth & development; Tendons/growth & development; Tissue Engineering/*methods
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Landis William J; Jacquet Robin; Hillyer Jennifer; Zhang Jean; Siperko Lorraine; Chubinskaya Susan; Asamura Shinichi; Isogai Noritaka, “The potential of tissue engineering in orthopedics.,” NEOMED Bibliography Database, accessed April 26, 2025, https://neomed.omeka.net/items/show/3755.