The potential of tissue engineering in orthopedics.

Title

The potential of tissue engineering in orthopedics.

Creator

Landis William J; Jacquet Robin; Hillyer Jennifer; Zhang Jean; Siperko Lorraine; Chubinskaya Susan; Asamura Shinichi; Isogai Noritaka

Publisher

The Orthopedic clinics of North America

Date

2005
2005-01

Description

This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The cell-polymer constructs are vascularized by the host mice, form new bone, cartilage, and tendon with characteristic gene expression and protein synthesis and secretion, and maintain the shape of human phalanges with joints. The study demonstrates critical progress in the design and fabrication of bone, cartilage, and tendon by tissue engineering and the potential of this field for human clinical orthopedic applications.

Subject

*Artificial Limbs; *Bioprosthesis; *Orthopedics; Animals; Cartilage/growth & development; Finger Joint/growth & development; Fingers/growth & development; Humans; Mice; Periosteum/growth & development; Tendons/growth & development; Tissue Engineering/*methods

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

97–104

Issue

1

Volume

36

Citation

Landis William J; Jacquet Robin; Hillyer Jennifer; Zhang Jean; Siperko Lorraine; Chubinskaya Susan; Asamura Shinichi; Isogai Noritaka, “The potential of tissue engineering in orthopedics.,” NEOMED Bibliography Database, accessed January 20, 2022, https://neomed.omeka.net/items/show/3755.

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