Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.

Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.

Jamison J; Gilloteaux J; Nassiri M R; Tsai C C; Summers J

Nucleosides & nucleotides

1999

1999-07

Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleolar) processes of the host cell may be responsible for the synergistic antiviral activity.

Antiviral Agents/*pharmacology; HIV-1/*drug effects; Humans; Magnesium/*pharmacology; Microbial Sensitivity Tests; Poly A-U/*pharmacology; Vesicular stomatitis Indiana virus/*drug effects

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

1221–1222

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