Browse Items · NEOMED Bibliography Database

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

International guidelines for the treatment of community-acquired pneumonia in adults: the role of macrolides.

The significance of community-acquired pneumonia (CAP) has led to the publication of guidelines from numerous international organisations. Because the macrolide class of antimicrobials is active against most of the key pathogens associated with CAP,…

Evaluation and use of a rapid Staphylococcus aureus assay by an antimicrobial stewardship program.

PURPOSE: The performance of a rapid test for methicillin-resistant Staphylococcus aureus (MRSA) in a large community hospital was investigated. METHODS: A prospective observational study was conducted to evaluate an immunochromatographic assay (Alere…

Tags: 2013, Affinity, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, Anti-Bacterial Agents/administration & dosage/*pharmacology, Bacteriological Techniques, Barrett Heather L, Biological Assay – Methods, Cell Culture Techniques, Chromatography, Community, Department of Internal Medicine, DiPersio Joseph R, False Negative Reactions, File Thomas M Jr, Funding Source, Hospitals, Human, Humans, Methicillin-Resistant Staphylococcus Aureus – Analysis, Methicillin-Resistant Staphylococcus aureus/*isolation & purification, Microbial Sensitivity Tests, NEOMED College of Medicine, Observational Methods, Pasquale Timothy R, Prospective Studies, Sensitivity and Specificity, Staphylococcal Infections/*diagnosis/microbiology, Staphylococcus aureus/*isolation & purification, Time Factors, Trienski Tamara L

The science of selecting antimicrobials for community-acquired pneumonia (CAP).

BACKGROUND: Among infectious diseases, community-acquired pneumonia (CAP) is the leading cause of death in the United States and is associated with a substantial economic burden to the health care system. Initiating appropriate empiric therapy can be…

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control…

Tags: *International Cooperation, *Intraabdominal Infections/diagnosis/drug therapy/microbiology, 2016, Abbott Iain J, Abu-Zidan Fikri M, Adesunkanmi Abdulrashid Kayode, Agresta Ferdinando, Al-Dahir Sara, Al-Hasan Majdi N, Althani Asma A, Ansaloni Luca, Ansari Shamshul, Ansumana Rashid, Anti-Infective Agents/*pharmacology, Augustin Goran, Bala Miklosh, Balogh Zsolt J, Baraket Oussama, Bassetti Matteo, Beltran Marcelo A, Bernhard Michael, Bhangu Aneel, Biffl Walter L, Boermeester Marja A, Brecher Stephen M, Brink Adrian J, Buyne Otmar R, Cainzos Miguel A, Cairns Kelly A, Camacho-Ortiz Adrian, Catena Fausto, Chandy Sujith J, Cherry-Bukowiec Jill R, Chichom-Mefire Alain, Coccolini Federico, Coimbra Raul, Colijn Caroline, Corcione Antonio, Corcione Francesco, Cui Yunfeng, Curcio Daniel, De Simone Belinda, De Waele Jan J, Delibegovic Samir, Demetrashvili Zaza, Department of Internal Medicine, Dhingra Sameer, Di Carlo Isidoro, Di Saverio Salomone, Diaz Jose J, Dillip Angel, Dogjani Agron, Dorj Gereltuya, Doyle Michael P, Drug Resistance, Dupont Herve, Eachempati Soumitra R, Eckmann Christian, Egiev Valery N, Elmangory Mutasim M, Enani Mushira Abdulaziz, Ferrada Paula, Fitchett Joseph R, Fraga Gustavo P, Ghnnam Wagih, Giamarellou Helen, Gkiokas George, Goldberg Staphanie R, Gomes Carlos Augusto, Gomi Harumi, Griffiths Ewen A, Guessennd Nathalie, Guzman-Blanco Manuel, Hansen Sonja, Haque Mainul, Hecker Andreas, Heizmann Wolfgang R, Herzog Torsten, Hodonou Adrien Montcho, Hong Suk-Kyung, Humans, Inaba Kenji, Isik Arda, Iskandar Katia, Ivatury Rao R, Junior Gerson Alves Pereira, Jusoh Asri Che, Kafka-Ritsch Reinhold, Kaplan Lewis J, Kapoor Garima, Karamarkovic Aleksandar, Kees Martin G, Kenig Jakub, Khokha Vladimir, Kiguba Ronald, Kim Peter K, Kirkpatrick Andrew W, Kluger Yoram, Knox Matthew C, Koike Kaoru, Kok Kenneth Y Y, Kong Victory, Kumar Anand, Labbate Maurizio, Labricciosa Francesco M, Laterre Pierre-Francois, Latifi Rifat, Lee Jae Gil, Lee Young Ran, Leone Marc, Leppaniemi Ari, Li Yousheng, Liang Stephen Y, Loho Tonny, Lowman Warren, Maegele Marc, Maier Ronald V, Malama Sydney, Marei Hany E, Martin-Loeches Ignacio, Marwah Sanjay, Massele Amos, May Addison K, Mazuski John E, McFarlane Michael, Melo Renato Bessa, Melotti Rita M, Mertz Dominik, Microbial, Microbial Sensitivity Tests, Montravers Philippe, Moore Ernest E, Moore Frederick A, Negoi Ionut, NEOMED College of Medicine, Nicolau David P, Nord Carl Erik, Ofori-Asenso Richard, Omari AbdelKarim H, Ordonez Carlos A, Ouadii Mouaqit, Piazza Diego, Prognosis, Pupelis Guntars, Rawson Timothy Miles, Rems Miran, Rizoli Sandro, Roberts Jason A, Rocha Claudio, Ruppe Etienne, Sakakushev Boris, Sanchez-Garcia Miguel, Sartelli Massimo, Sato Norio, Sawyer Rob G, Segovia Lohse Helmut A, Sganga Gabriele, Shelat Vishal G, Siribumrungwong Boonying, Soreide Kjetil, Soto Rodolfo, Spellberg Brad, Talving Peep, Tilsed Jonathan V, Timsit Jean Francois, Trueba Gabriel, Trung Ngo Tat, Uhl Waldemar, Ulrych Jan, van Goor Harry, Vereczkei Andras, Viale Perluigi, Vincent Jean-Louis, Viscoli Claudio, Vohra Ravinder S, Wani Imtiaz, Watkins Richard R, Weber Dieter G, World journal of emergency surgery : WJES, Wright Brian J, Xiao Yonghong, Yuan Kuo-Ching, Zachariah Sanoop K, Zahar Jean-Ralph, Zakrison Tanya L

Gemifloxacin versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis. The 070 Clinical Study group.

Six hundred patients were evaluated in this randomized, double-blind, double-dummy, multicenter, parallel-group study comparing the efficacy and safety of gemifloxacin (320 mg once-daily for 5 days) and amoxicillin/clavulanate (500/125 mg three-times…

Tags: *Fluoroquinolones, 2000, 80 and over, Acute-Phase Reaction, Adult, Aged, Amoxicillin/pharmacology/therapeutic use, Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use, Bronchitis/*drug therapy, Chronic Disease, Clavulanic Acid/pharmacology/therapeutic use, Combination/pharmacology/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Female, File T, Garau J, Gemifloxacin, Haemophilus influenzae/drug effects, Humans, Journal of chemotherapy (Florence, Italy), Lode H, Lynch S, Male, Microbial Sensitivity Tests, Middle Aged, Moraxella (Branhamella) catarrhalis/drug effects, Multicenter Studies as Topic, Naphthyridines/adverse effects/pharmacology/*therapeutic use, NEOMED College of Medicine, Schlemmer B, Streptococcus pneumoniae/drug effects, Treatment Outcome, Young C

Resveratrol inhibition of Propionibacterium acnes.

OBJECTIVES: To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth. METHODS: Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L.…

Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Background: Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide.…

Tags: *beta-Lactam Resistance, *carbapenem-resistant Enterobacteriaceae, *Colistin, *Klebsiella pneumoniae, *mortality, *ST258, 2017, Aged, Anti-Bacterial Agents/pharmacology/*therapeutic use, beta-Lactamases/genetics, Bonomo Robert A, Carbapenems/pharmacology/therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Cober Eric, Colistin/pharmacology/*therapeutic use, Comorbidity, Department of Internal Medicine, Doi Yohei, Domitrovic T Nicholas, Evans Scott, Female, Fowler Vance G Jr, Hujer Andrea M, Hujer Kristine M, Humans, Kalayjian Robert C, Kaplan-Meier Estimate, Kaye Keith S, Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality, Klebsiella pneumoniae/classification/*drug effects/genetics, Male, Marshall Steve, Microbial Sensitivity Tests, Middle Aged, NEOMED College of Medicine, Perez Federico, Phylogeny, Proportional Hazards Models, Richter Sandra S, Rojas Laura J, Rudin Susan D, Salata Robert A, Salim Madiha, van Duin David, Watkins Richard R

SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia.

BACKGROUND: Solithromycin, a novel macrolide antibiotic with both intravenous and oral formulations dosed once daily, has completed 2 global phase 3 trials for treatment of community-acquired bacterial pneumonia. METHODS: A total of 863 adults with…

Tags: *clinical trial, *Community-acquired, *Pneumonia, *solithromycin, *Streptococcus pneumoniae, 2016, 80 and over, Administration, Adult, Aged, Anti-Bacterial Agents/*administration & dosage/adverse effects, Bacterial, Bacterial/diagnosis/*drug therapy/*microbiology, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/diagnosis/*drug therapy/*microbiology, Comorbidity, Das Anita F, Department of Internal Medicine, Drug Resistance, Female, Fernandes Prabhavathi, File Thomas M Jr, Fluoroquinolones/*administration & dosage/adverse effects, Gonong Joven Roque V, Humans, Intravenous, Jamieson Brian D, Keedy Kara, Macrolides/*administration & dosage/adverse effects, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, NEOMED College of Medicine, Oldach David, Oral, Pneumonia, Rewerska Barbara, Sheets Amanda, Taylor David, Treatment Outcome, Triazoles/*administration & dosage/adverse effects, Vucinic-Mihailovic Violeta

Recommendations for treatment of hospital-acquired and ventilator-associated pneumonia: review of recent international guidelines.

Recently published guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia are reviewed for recommendations regarding diagnosis and antimicrobial therapy to assess the implications for development of future…

Tags: *Practice Guidelines as Topic, 2010, Anti-Bacterial Agents/*therapeutic use, Bacteria/drug effects/isolation & purification, Bacterial/diagnosis/*drug therapy, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Cross Infection/diagnosis/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Hospitals, Humans, Microbial Sensitivity Tests, NEOMED College of Medicine, Pneumonia, Time Factors, Ventilator-Associated/diagnosis/*drug therapy

A formidable foe: carbapenem-resistant Acinetobacter baumannii and emerging nonantibiotic therapies.

Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.

Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or…

Tags: 1999, Antiviral Agents/*pharmacology, Gilloteaux J, HIV-1/*drug effects, Humans, Jamison J, Magnesium/*pharmacology, Microbial Sensitivity Tests, Nassiri M R, Nucleosides & nucleotides, Poly A-U/*pharmacology, Summers J, Tsai C C, Vesicular stomatitis Indiana virus/*drug effects

Outcome of treatment of respiratory tract infections due to Streptococcus pneumoniae, including drug-resistant strains, with pharmacokinetically enhanced amoxycillin/clavulanate.

The efficacy of a new pharmacokinetically enhanced formulation of amoxycillin/clavulanate (AMX/CA) 2000/125 mg, twice daily, designed to provide adequate levels of amoxycillin over the 12-h dosing interval to eradicate penicillin-resistant…

Tags: *Treatment Outcome, 2002, 80 and over, Adolescent, Adult, Aged, Amoxicillin-Potassium Clavulanate Combination/administration & dosage/*pharmacokinetics/pharmacology/*therapeutic use, Amoxicillin/adverse effects/therapeutic use, Bacterial, Bacterial/drug therapy/immunology, Bronchitis/drug therapy/microbiology, Combination/adverse effects/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Administration Schedule, Drug Resistance, Drug Therapy, Female, File Thomas M Jr, Follow-Up Studies, Humans, International journal of antimicrobial agents, Jacobs Michael R, Male, Microbial Sensitivity Tests, Middle Aged, Multicenter Studies as Topic, NEOMED College of Medicine, Pneumonia, Poole Michael D, Respiratory Tract Infections/*drug therapy/metabolism/microbiology, Streptococcal Infections/*drug therapy/metabolism/microbiology, Streptococcus pneumoniae/*drug effects, Wynne Brian

Antipseudomonal penicillins.

Antipseudomonal penicillins retain most of the antibacterial activity of penicillin and aminopenicillins. This group of penicillins has added activities against many gram-negative rods, including P. aeruginosa. Similar to the earlier penicillins,…

Tags: 1995, Anti-Bacterial Agents/pharmacology, Department of Internal Medicine, Drug Resistance, File T M Jr, Humans, Microbial, Microbial Sensitivity Tests, NEOMED College of Medicine, Penicillins/adverse effects/pharmacokinetics/*therapeutic use, Pseudomonas Infections/*drug therapy, Pseudomonas/*drug effects, Tan J S, The Medical clinics of North America

A disease model descriptive of progression between chronic obstructive pulmonary disease exacerbations and community-acquired pneumonia: roles for underlying lung disease and the pharmacokinetics/pharmacodynamics of the antibiotic.

Patients with chronic obstructive pulmonary disease (COPD) may progress to community-acquired pneumonia (CAP), but there has been no formal study of the factors responsible. We studied the influence of severity of underlying lung disease, pathogen…

Tags: *Anti-Bacterial Agents/pharmacokinetics/therapeutic use, *Community-Acquired Infections/drug therapy/microbiology/physiopathology/prevention & control, *Models, *Pneumonia, 2009, Adelman Martin H, Aged, Area Under Curve, Bacterial/drug therapy/microbiology/physiopathology/prevention & control, Biological, Bronchitis, Chronic Obstructive/drug therapy/microbiology/*physiopathology, Chronic/drug therapy/microbiology/physiopathology, Department of Internal Medicine, Disease Progression, Female, File Thomas M Jr, Humans, International journal of antimicrobial agents, Klugman Keith P, Lavin Bruce, Lung Diseases/complications/drug therapy/microbiology, Lung/microbiology, Male, Microbial Sensitivity Tests, Middle Aged, Monte Scott V, NEOMED College of Medicine, Paladino Joseph A, Pneumococcal/drug therapy/microbiology/physiopathology/prevention & control, Pneumonia, Pulmonary Disease, Schentag Jerome J, Severity of Illness Index, Singer Mendel E, Streptococcus pneumoniae/*drug effects, Yu Victor L

Evolution of amoxicillin/clavulanate in the treatment of adults with acute bacterial rhinosinusitis and community-acquired pneumonia in response to antimicrobial-resistance patterns.

Current treatment guidelines for community-acquired respiratory tract infections no longer depend solely on the characteristics of the patient and the clinical syndrome, but on those of the offending pathogen, including presence and level of…

Tags: 2004, Amoxicillin-Potassium Clavulanate Combination/*therapeutic use, Anti-Bacterial Agents/pharmacology, Bacteria/drug effects/isolation & purification, Bacterial, Benninger Michael S, Clinics in laboratory medicine, Combination/*therapeutic use, Community-Acquired Infections/drug therapy/microbiology, Department of Internal Medicine, Drug Resistance, Drug Therapy, File Thomas M Jr, Humans, Jacobs Michael R, Microbial Sensitivity Tests, NEOMED College of Medicine, Pneumonia/*drug therapy/microbiology, Sinusitis/*drug therapy/microbiology

The antiviral activity of RNA-dye combinations.

The results of our previous studies (Jamison et al. 1988, 1989, 1990 a, b, c, d, e) have shown that the ability of intercalative dyes to modulate the antiviral activity of poly r(A-U) is related to the groove through which the dyes intercalate into…

Tags: 1994, Antiviral Agents/*toxicity, Coloring Agents/*toxicity, Double-Stranded/*toxicity, Gilloteaux J, Jamison J M, Microbial Sensitivity Tests, Poly A-U/*toxicity, Progress in molecular and subcellular biology, RNA, Structure-Activity Relationship, Summers J L

Browse Items (17 total)