Browse Items (373 total)

Implementing procedural sedation and analgesia in the emergency department is still is a challenge on an international scale. Here, we describe the Dutch setting of emergency medicine and explain the strategies that were successful for the…

Staphylococcus lugdunensis is a coagulase-negative Staphylococcus capable of causing infective endocarditis on native as well as prosthetic valves and implanted cardiac devices. It causes acute disease clinically indistinguishable from that caused by…

Objective: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, lipid accumulation in…

Cognitive behavioral therapy with exposure and response prevention (CBT-E/RP) is the first-line treatment for obsessive-compulsive disorder (OCD). Several CBT-E/RP treatment manuals exist, yet clinicians still struggle to implement this…

The self-medication hypothesis proposes that individuals experiencing posttraumatic stress disorder (PTSD) symptoms may use alcohol (or other substances) to self-medicate distress, while the mutual maintenance hypothesis proposes that alcohol use…

Folate is widely used as a target ligand for tumor cells, and poly (L-aspartic acid)-b-poly-(L-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect,…

Retroperitoneal sarcomas are rare tumors, having an annual incidence of 0.3 to 0.4 new cases per 100,000 occupants. R0 resection is the cornerstone of therapy, with local control being integral for a favorable prognosis. We present a case of giant…

Neuromuscular blocking agents (NMBAs) play an important role in the management of a large number of hospital patients. The pharmacology of NMBAs is well understood, but the use of these agents can be controversial. NMBAs are common in surgical…

Nonalcoholic steatohepatitis (NASH) is characterized by progressive liver injury, inflammation, and fibrosis; however, the mechanisms that govern the transition from hepatic steatosis, which is relatively benign, to NASH remain poorly defined.…

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