Browse Items · NEOMED Bibliography Database

Preclinical evaluation of triiodothyronine nanoparticles as a novel therapeutic intervention for resuscitation from cardiac arrest

Background: Given emerging evidence of rapid non-genomic cytoprotective effects of triiodothyronine (T3), we evaluated the resuscitative efficacy of two nanoparticle formulations of T3 (T3np) designed to prolong cell membrane receptor-mediated…

Tags: 2023, cardiac arrest, Ischemic Injury, Nanoparticles, Phosphocreatine, Thyroid hormone, triiodothyronine

Nose-to-brain co-delivery of repurposed simvastatin and BDNF synergistically attenuates LPS-induced neuroinflammation

A therapeutic strategy that can combat the multifaceted nature of neuroinflammation pathology was investigated. Thus, we fabricated PEG-PdLLA polymersomes and evaluated the efficacy in co-delivery of simvastatin (Sim, as a repurposed…

Tags: 2019, And Medicine, Biology, Department of Pharmaceutical Sciences, Drug repurposing, Intranasal delivery, Journal Article, Lin Li, Manickavasagam Dharani, Microglia, Nanomedicine: Nanotechnology, Nanomedicine: Nanotechnology, Biology, And Medicine, Nanoparticles, NEOMED College of Pharmacy, NEOMED College of Pharmacy Student, NEOMED Student Publications, November 2019 Update, Oyewumi Moses O, polymersomes

Recognition Sites for Cancer-Targeting Durg Delivery Systems

BACKGROUND: Target-homing drug delivery systems are now gaining significant traction for use as novel therapeutic approaches in antitumor targeting for cancer therapy. Numerous targeted drug delivery systems have been designed to improve the…

Tags: 2019, Anhui Medical University, Bao Jianwei, Current Drug Metabolism, Czech Tori, Department of Pharmaceutical Sciences, Guan Siyu, Hu Rongfeng, Journal Article, ligand, Nanoparticles, NEOMED College of Pharmacy, NEOMED College of Pharmacy Student, November 2019 Update, Recognition sites, Tang Jihui, targeted drug delivery system, Tumor, Zhang Qianqian

Affinity Manipulation Of Surface-conjugated Rgd Peptide To Modulate Binding Of Liposomes To Activated Platelets

Platelet adhesion, activation and fibrinogen-mediated aggregation are primary events in vascular thrombosis and occlusion. An injectable delivery system that can carry thrombolytics selectively to the sites of active platelet aggregation has immense…

In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles

Folate is widely used as a target ligand for tumor cells, and poly (L-aspartic acid)-b-poly-(L-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect,…

Dextran-Peptide Hybrid for Efficient Gene Delivery

Gene therapy has drawn significant interest in the past two decades since it provides a promising strategy to treat both genetic disorders and acquired diseases. However, the transfer of gene therapy to clinical applications is troubled with many…

Cholesterol-Peptide Hybrids to Form Liposome-Like Vesicles for Gene Delivery

In this paper, four amphiphilic cholesterol-peptide conjugates (Ch-R5H5, Ch-R3H3, Ch-R5 and Ch-R5) were designed and synthesized, and their properties in gene delivery were evaluated in vitro with an aim of developing more efficient gene delivery…

Tags: 2013, Cao B, Cheng G, condensation, DNA, histidine, Journal Article, Nanoparticles, oligopeptides, PloS one, Polymers, prospects, Science & Technology - Other Topics, systems, Tang Q, therapy, vectors, Wu H Y

Light-Activatable Gold Nanoshells for Drug Delivery Applications

Gold nanoshells (AuNSs) are currently being investigated as nanocarriers for drug delivery systems and have both diagnostic and therapeutic applications, including photothermal ablation, hyperthermia, drug delivery, and diagnostic imaging,…

Delivery Systems as Vital Tools in Drug Repurposing.

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we…

Tags: *Drug Delivery Systems, *Drug Repositioning, 2019, AAPS PharmSciTech, combination drugs, Czech Tori, Department of Pharmaceutical Sciences, Drug Carriers, drug development, Humans, Lalani Reza, nanocarriers, Nanoparticles, NEOMED College of Pharmacy, Oyewumi Moses O, Tissue Distribution

Drug Delivery and Nanoformulations for the Cardiovascular System.

Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of disease state, including atherosclerosis, ischemic-reperfusion injury and other types of microvascular diseases including…

Tags: 2017, Atherosclerosis, Cardiac death, Department of Integrative Medical Sciences, Drug delivery, Exosomes, Formulation, Geldenhuys W J, Khayat M T, myocardial infarction, Nanoparticles, Nayeem M A, NEOMED College of Medicine, Research & reviews. Drug delivery, Targeting, Vascular tone, Yun J

Gelucire-stabilized nanoparticles as a potential DNA delivery system.

Clinical viability of gene delivery systems has been greatly impacted by potential toxicity of the delivery systems. Recently, we reported the nanoparticle (NP) preparation process that employs biocompatible materials such as Gelucire(R) 44/14 and…

Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.

Paclitaxel is not effective for treatment of brain cancers because it cannot cross the blood-brain barrier (BBB) due to efflux by P-glycoprotein (P-gp). In this work, glutathione-coated poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) of…

Tags: *Drug Delivery Systems, 2011, Adenosine Triphosphatases/metabolism, Animals, Antineoplastic Agents, ATP Binding Cassette Transporter, Blood-Brain Barrier/metabolism, Brain Neoplasms/drug therapy, Bui Thong, Cell Death/drug effects, Cell Line, Coumarins/administration & dosage/pharmacokinetics, Delayed-Action Preparations, Geldenhuys Werner, Glioma/drug therapy/pathology, Glutathione/*chemistry, Harrison Kimberly, Humans, Inbred C57BL, Journal of drug targeting, Male, Mbimba Thomas, Member 1/metabolism, Mice, Microtubules/metabolism, Nanoparticles, Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology, Particle Size, Permeability, Phytogenic/administration & dosage/*pharmacokinetics/pharmacology, Rats, Subfamily B, Sutariya Vijaykumar, Thiazoles/administration & dosage/pharmacokinetics, Tubulin/metabolism, Tumor

Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.

Brain-targeted Tempol-loaded poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) conjugated with a transferrin antibody (OX 26) were developed using the nanoprecipitation method. These NPs may have utility in treating neurodegenerative diseases…

Delivery Systems as Vital Tools in Drug Repurposing.

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we…

Tags: 2019, AAPS PharmSciTech, combination drugs, Czech Tori, Department of Pharmaceutical Sciences, Drug Delivery Systems, drug development, Lalani Reza, nanocarriers, Nanoparticles, NEOMED College of Pharmacy, Oyewumi Moses O

Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration.

Simvastatin (Sim) is a widely known drug in the treatment of hyperlipidemia, which has attracted so much attention in bone regeneration due to its potential osteoanabolic effect. However, repurposing of Sim in bone regeneration will require suitable…

Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug.

Treatment strategies for glaucoma will benefit from injectable and/or implantable delivery systems that can achieve sustained delivery of neuroprotective agents (to the posterior segment) and/or intraocular pressure lowering drugs (to the anterior…

Engineering triiodothyronine (T3) nanoparticle for use in ischemic brain stroke.

A potential means of pharmacological management of ischemic stroke is rapid intervention using potent neuroprotective agents. Thyroid hormone (T3) has been shown to protect against ischemic damage in middle cerebral artery occlusion (MCAO) model of…

Tags: 2013, Blood-brain barrier, Brain stroke, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug delivery and translational research, Geldenhuys Werner J, Mdzinarishvili Alexander, Nanoparticles, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Neuroprotection, Sadana Prabodh, Sutariya Vijaykumar, Talasila Phani K, Thyroid hormone

Browse Items (17 total)