Delivery Systems as Vital Tools in Drug Repurposing.

Delivery Systems as Vital Tools in Drug Repurposing.

Czech Tori; Lalani Reza; Oyewumi Moses O

AAPS PharmSciTech

2019

2019-02

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs.

combination drugs; drug delivery systems; drug development; nanocarriers; nanoparticles

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