In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles

Title

In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles

Creator

Hong W X; Hu R F; Huang X C; Lu X Q; Czech T; Tang J H

Publisher

Journal of Drug Delivery Science and Technology

Date

2017
2017-10

Description

Folate is widely used as a target ligand for tumor cells, and poly (L-aspartic acid)-b-poly-(L-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect, folate-conjugated PAA-PPA micelles were synthesized. To evaluate the hypothesis, we assessed the pharmacokinetics and biodistribution of.a new antitumor drug 4-amino-2-trifluoromethyl-phenyl retinate (ATPR) loaded into the micelles. We also observed in vivo imaging of 1,1'-dioctadecy1-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) loaded micelles to confirm distribution. The results showed that ATPR-loaded, folate-modified PAA-PPA displayed a prolonged circulation half-life and iinproved the targeting effect. (C) 2017 Elsevier B.V. All tights reserved.

Subject

cancer; cellular uptake; copolymer micelles; Drug; drug-delivery; Folate; nanoparticles; nanoparticles; Pharmacokinetics; Pharmacology & Pharmacy; polymeric micelles; targeted delivery; targeting; Tissue distribution

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

436-443

Volume

41

Citation

Hong W X; Hu R F; Huang X C; Lu X Q; Czech T; Tang J H, “In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles,” NEOMED Bibliography Database, accessed June 24, 2021, https://neomed.omeka.net/items/show/10219.

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