Browse Items (61 total)
- Tags: Geldenhuys Werner J
A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson's disease.
Evolution of a Natural Products and Nutraceuticals Course in the Pharmacy Curriculum.
Tags: *Biological Products/therapeutic use, *Clinical Competence, *Dietary Supplements, *Students, 2015, American journal of pharmaceutical education, course curriculum, Cudnik Michelle L, Curriculum/*trends, Darvesh Altaf S, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dietary Supplements, Education, Educational Measurement/methods, Evidence-Based Medicine, Geldenhuys Werner J, herbal products, Humans, Krinsky Daniel L, NEOMED College of Pharmacy, Nutraceuticals, Pharmacy, Pharmacy/methods/*trends
Molecular determinants of blood-brain barrier permeation.
Tags: *Drug Delivery Systems, 2015, Adkins Chris E, Animals, Blood-Brain Barrier/*metabolism, Brain/drug effects, Computer Simulation, Geldenhuys Werner J, high-throughput, Humans, in silico, Lockman Paul R, logPS, Mohammad Afroz S, nutrient transporters, Permeability, Therapeutic delivery, Virtual screening
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.
Tags: *drug discovery, *Ligands, 2017, Adenosine/metabolism, Animals, Atherosclerosis, Cardiac death, Cardiovascular Diseases/drug therapy/metabolism, Cardiovascular System/metabolism, Department of Integrative Medical Sciences, Geldenhuys Werner J, Hanif Ahmad, Humans, Hydrogen Bonding, Models, Molecular, Molecular Structure, Molecules (Basel, Switzerland), myocardial infarction, Nayeem Mohammed A, NEOMED College of Medicine, Protein Binding, Purinergic P1/*chemistry/*metabolism, Receptors, Signal Transduction, Structure-Activity Relationship, Vascular tone, Yun June
The blood-brain barrier choline transporter.
Tags: 2012, Allen David D, Animals, Blood-Brain Barrier/drug effects/*metabolism, Central nervous system agents in medicinal chemistry, Drug Delivery Systems/*methods, Geldenhuys Werner J, Humans, Membrane Transport Proteins/*metabolism, Organic Cation Transport Proteins/metabolism, Organic Cation Transporter 1/metabolism, Organic Cation Transporter 2
Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Tags: 2017, ADME, Animals, Antineoplastic Agents/*therapeutic use, Apoptosis, Brain cancer, Brain Neoplasms/*drug therapy/pathology/*secondary, Breast Neoplasms/*pathology, Cell Line, Chemotherapy, CNS, Current cancer drug targets, Department of Anatomy & Neurobiology, distribution, Drug Discovery, Drug Resistance, Female, Geldenhuys Werner J, Griffith Jessica I G, Humans, Lockman Paul R, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Terell-Hall Tori B, Tumor, Venishetty Vinay K
Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
Tags: 2007, Alzheimer Disease/pathology/*prevention & control, Amit Tamar, Animals, Avramovich Yael, Bar Am Orit, Biological, Central Nervous System/chemistry/*drug effects/metabolism, Current Alzheimer research, Drug Design, Fridkin Mati, Gal Shunit, Geldenhuys Werner J, Humans, Mandel Silvia, Models, Neuroprotective Agents/*chemistry/pharmacology/*therapeutic use, Neurotransmitter Agents/chemistry/*metabolism, Sagi Yotam, Van der Schyf Cornelis J, Weinreb Orly, Youdim Moussa B H, Zheng Hailin
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Tags: 2012, Animals, Anticarcinogenic Agents/pharmacology/*therapeutic use, Awale Prabha, Bhatia Deepak, Bishayee Anupam, Carroll Richard T, Current pharmaceutical biotechnology, Cytokines/genetics/*metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine, Experimental/chemically induced/metabolism/*prevention & control, Female, Geldenhuys Werner J, Gene Expression Regulation/drug effects, Liver Neoplasms, Liver/drug effects/metabolism, Mbimba Thomas, Messenger/metabolism, NEOMED College of Pharmacy, Phenobarbital, Rats, Resveratrol, RNA, Sprague-Dawley, Stilbenes/pharmacology/*therapeutic use
Natural products of dietary origin as lead compounds in virtual screening and drug design.
Tags: *Biological Products/pharmacology, *Drug Design, 2012, Animals, Bishayee Anupam, Caffeine/pharmacology, Carroll Richard T, Curcumin/pharmacology, Current pharmaceutical biotechnology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Geldenhuys Werner J, Genistein/pharmacology, Humans, NEOMED College of Pharmacy, Resveratrol, Stilbenes/pharmacology
Role of serotonin in Alzheimer's disease: a new therapeutic target?
Tags: 2011, Alzheimer Disease/*drug therapy/*metabolism, Alzheimer's Disease – Drug Therapy, Alzheimer's Disease – Metabolism, Animals, Cell Surface – Metabolism, Clinical Trials, Clinical Trials as Topic, CNS drugs, Drug Evaluation, Geldenhuys Werner J, Humans, Preclinical, Receptors, Serotonin – Pharmacodynamics, Serotonin – Therapeutic Use, Serotonin/*metabolism, Serotonin/*pharmacology/*therapeutic use, Van der Schyf Cornelis J
Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.
Tags: 2010, Alzheimer Disease/*physiopathology/*therapy, Animals, Antioxidants/*administration & dosage/chemistry/pharmacology, Bishayee Anupam, Carroll Richard T, Darvesh Altaf S, Department of Pharmaceutical Sciences, Expert review of neurotherapeutics, Flavonoids/*administration & dosage/chemistry/pharmacology, Geldenhuys Werner J, Humans, Mitochondria/drug effects/physiology, NEOMED College of Pharmacy, Neurodegenerative Diseases/physiopathology, Oxidative Stress/drug effects/*physiology, Phenols/*administration & dosage/chemistry/pharmacology, Polyphenols, Van der Schyf Cornelis J
The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.
Tags: 2009, Alzheimer Disease/*complications, Animals, Biological, Cognition Disorders/*drug therapy/*etiology, Drug Design, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, Models, Receptors, Serotonin Antagonists/chemistry/*therapeutic use, Serotonin/*metabolism, Structure-Activity Relationship, Van der Schyf Cornelis J
Pharmacotherapy of Alzheimer's disease: current and future trends.
Tags: 2015, Alzheimer Disease/*drug therapy, Alzheimer's disease, Anti-Inflammatory Agents, Antioxidants, cholinesterase inhibitors, Darvesh Altaf S, dementia, Department of Pharmaceutical Sciences, Drug Therapy/*methods/*trends, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, immunotherapy, memantine, multi-targeted drugs, natural products, NEOMED College of Pharmacy, Pharmacotherapy
Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.
In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery.
Novel models for assessing blood-brain barrier drug permeation.
Tags: *Capillary Permeability, 2012, Allen David D, Animal, Animals, Blood-Brain Barrier/*metabolism, Bloomquist Jeffrey R, Drosophila melanogaster/metabolism, Expert opinion on drug metabolism & toxicology, Geldenhuys Werner J, Grasshoppers/metabolism, High-Throughput Screening Assays, Humans, Models, Pharmaceutical Preparations/*metabolism, Zebrafish/metabolism
Curcumin and neurodegenerative diseases: a perspective.
Tags: 2012, Animals, Bishayee Anupam, Carroll Richard T, Curcumin/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use, Darvesh Altaf S, Department of Pharmaceutical Sciences, Drug Evaluation, Expert opinion on investigational drugs, Geldenhuys Werner J, Humans, NEOMED College of Pharmacy, Neurodegenerative Diseases/*drug therapy/metabolism, Neuroprotective Agents/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use, Novotny Nicholas A, Oxidative Stress/drug effects, Preclinical, Van der Schyf Cornelis J
Parkinson's disease biomarker: a patent evaluation of WO2013153386.
Tags: 2014, Abdelmagid Samir M, Autophagy, Biomarkers/metabolism, clinical testing, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Disease Progression, Dopaminergic Neurons/pathology, Expert opinion on therapeutic patents, Gallegos Patrick J, Geldenhuys Werner J, Humans, Mitochondria/pathology, mitochondrial membrane potential, mitophagy, NEOMED College of Medicine, NEOMED College of Pharmacy, Parkinson Disease/*diagnosis/physiopathology, Patents as Topic, Phosphorylation, Protein Kinases/*metabolism, Safadi Fayez F, Ubiquitin-Protein Ligases/*metabolism
Biocompatibility, efficacy and biodistribution of Gelucire-stabilized nanoparticles engineered for docetaxel delivery.
Tags: *Biocompatible Materials, *Nanoparticles, 2012, Animals, Antineoplastic Agents/*administration & dosage/pharmacokinetics/pharmacology, Bi Lipeng, Department of Pharmaceutical Sciences, Docetaxel, Geldenhuys Werner J, Journal of nanoscience and nanotechnology, Macrophage Activation/drug effects, NEOMED College of Pharmacy, Oyewumi Moses O, Platelet Aggregation/drug effects, Rats, Reactive Oxygen Species/metabolism, Taxoids/*administration & dosage/pharmacokinetics/pharmacology, Tissue Distribution, Wehrung Daniel
Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles.
Tags: *Lethal Dose 50, 2013, Adenocarcinoma/*drug therapy/pathology, Animals, Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity, Bi Lipeng, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Stability, Drug Tolerance, Gallium/*administration & dosage/pharmacokinetics/*toxicity, Geldenhuys Werner J, Humans, Journal of biomedical nanotechnology, Metabolic Clearance Rate, Mice, Nanocapsules/*administration & dosage/chemistry/*toxicity, NEOMED College of Pharmacy, Nude, Organ Specificity, Oyewumi Moses O, Tissue Distribution, Treatment Outcome, Triglycerides/chemistry, Tumor, Wehrung Daniel
Development and validation of a novel RP-HPLC method for the analysis of reduced glutathione.
Tags: 2012, Chromatography, Geldenhuys Werner J, Glutathione/*analysis, High Pressure Liquid/*methods, Journal of chromatographic science, Limit of Detection, Linear Models, Nanoparticles/chemistry, Pharmaceutical Preparations/chemistry, Reproducibility of Results, Reverse-Phase/*methods, Spectrophotometry, Sutariya Vijaykumar, Ultraviolet, Wehrung Daniel
Generation and characterization of ATP analog-specific protein kinase Cdelta.
Tags: 2015, Adenosine Triphosphate/*analogs & derivatives/*chemistry, Amino Acid, Amino Acid Sequence, Animals, ATP, Catalysis, Cercopithecus aethiops, Chemical Biology, Chou Wen-Hai, COS Cells, Geldenhuys Werner J, Glutamine/chemistry, Han Xiqian, Humans, Inbred C57BL, Kumar Varun, Leucine/chemistry, Lysine/chemistry, Messing Robert O, Mice, Molecular Sequence Data, Neutrophils/metabolism, Phenylalanine/chemistry, Phosphorylation, Protein Binding, Protein Kinase C (PKC), Protein Kinase C-delta/*metabolism, Protein Phosphorylation, Purines/chemistry, Sequence Homology, Signal Transduction, stroke, Substrate Specificity, Superoxides/chemistry, The Journal of biological chemistry, Transgenic, Wang Dan, Weng Yi-Chinn
Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling.
Tags: *MAP Kinase Signaling System, *Signal Transduction, 2016, Abdelmagid Samir M, Animals, Cell Differentiation, Cells, Cultured, Department of Anatomy & Neurobiology, Experimental & molecular medicine, Eye Proteins/*metabolism, Geldenhuys Werner J, Hyaluronan Receptors/*metabolism, Inbred C57BL, Jaber Fatima A, Male, Mbimba Thomas S, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, Osteoclasts/*cytology/metabolism, RANK Ligand/metabolism, Recombinant Proteins/metabolism, Safadi Fayez F, Sondag Gregory R, Yu Bing
Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor.
Tags: *Models, *Narcotic Antagonists, *Quantitative Structure-Activity Relationship, 2010, Animals, Binding, Calcium Signaling/drug effects, CHO Cells, Competitive, Cricetinae, Cricetulus, Databases, Factual, Geldenhuys Werner J, Humans, Journal of medicinal chemistry, Kuzenko Stephanie R, Ligands, Molecular, Neurokinin-3/*antagonists & inhibitors/chemistry, Opioid/chemistry, Quinolines/*chemistry/pharmacology, Radioligand Assay, Receptors, Simmons Mark A
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Tags: *Aging, *Disease Models, *drug discovery, *mitochondrial dysfunction, *mitoNEET, 2017, ACS chemical neuroscience, Animal, Animals, Benkovic Stanley A, Brown Candice M, Corpus Striatum/*metabolism/*pathology, Crish Samuel D, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Inbred C57BL, Iron-Binding Proteins/genetics/*metabolism, Knockout, Lin Li, Male, Membrane Proteins/genetics/*metabolism, Mice, Mitochondria/*metabolism/*pathology, NEOMED College of Pharmacy, Parkinson Disease/*metabolism/pathology, Richardson Jason R, Sullivan Patrick G, Yonutas Heather M
The emergence of designed multiple ligands for neurodegenerative disorders.
Tags: *Drug Design, *Ligands, 2011, Amyloid beta-Peptides/metabolism, Antiparkinson Agents/therapeutic use, Carroll Richard T, Clinical Trials as Topic, Geldenhuys Werner J, Humans, Molecular Structure, Neurodegenerative Diseases/*drug therapy, Neuroprotective Agents/*therapeutic use, Progress in neurobiology, Van der Schyf Cornelis J, Youdim Moussa B H
Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?
Tags: *Drug Design, 2009, Adamantane/chemistry/pharmacology, Animals, Central Nervous System Diseases/*drug therapy, Geldenhuys Werner J, Humans, Molecular Structure, Neuroprotective Agents/chemistry/*pharmacology/therapeutic use, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, Polycyclic Compounds/*chemistry/pharmacology/therapeutic use, Psychotropic Drugs/chemistry/*pharmacology/therapeutic use, Quantitative Structure-Activity Relationship, Van der Schyf Cornelis J
Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.
Tags: 2012, Animals, Biomarkers/metabolism, Blotting, Body Temperature/drug effects, Body Weight/drug effects, Buletko A Blake, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/metabolism, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, HSP70 Heat-Shock Proteins/metabolism, Inbred Strains, Male, McDermott Janet L, Methamphetamine/*toxicity, Mice, NEOMED College of Pharmacy, Neurotoxicity Syndromes/*etiology/metabolism, Neurotoxicology and teratology, Oxidative Stress/drug effects, Testosterone Propionate/*pharmacology, Vesicular Monoamine Transport Proteins/metabolism, Western
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Tags: 2012, Animals, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, Inbred C57BL, Indoles/*pharmacology, Methamphetamine/*pharmacology, Mice, NEOMED College of Pharmacy, Neurochemistry international
Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum.
Tags: 2014, Anderson David J, Animals, Bridged-Ring Compounds/*blood, Calcium Channel Blockers/*blood, Chromatography, Crish Samuel D, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Gobburi Ashta Lakshmi Prasad, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Liquid/*methods, Mice, Mouse serum, Multifunctional drug, N-Methyl-D-Aspartate/*antagonists & inhibitors, NEOMED College of Pharmacy, Neuroprotective agent, NGP1-01, Pedada Kiran K, Pentacycloundecylamine, Receptors, Reproducibility of Results, Tandem Mass Spectrometry/*methods, Van der Schyf Cornelis J, Zhou Xiang
A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.
Tags: %CV, %RE, 1-Methyl-4-phenyl-1, 2, 2014, 3, 3-thiazolidine-2, 4-dione, 5-[3, 5-[4-hydroxy-3, 5-di-tert-butyl-4-hydroxyphenyl)methyl]-1, 5-dimethyl-phenyl)methyl]thiazolidine-2, 6-tetrahydropyridine, Anderson David J, Animals, Carroll Richard T, Carry-over, Chromatography, Department of Internal Medicine, Geldenhuys Werner J, High Pressure Liquid/*methods, internal standard, IS, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Lin Li, LLOQ, lower limit of quantification, Methanol, Mice, mitoNEET, Mouse serum, MPTP, MRM, multiple reaction monitoring, NEOMED College of Medicine, NL-1, NL-2, Pedada Kiran K, percent coefficient of variation, peroxisome proliferator activated receptor-gamma, pharmacokinetic, PK, PPAR-gamma, QC, Quality Control, relative error, relative matrix effect, RME, SD, standard deviation, Tandem Mass Spectrometry/*methods, thiazolidinedione, Thiazolidinedione (TZD), Thiazolidinediones/*blood, TZD, Zhou Xiang
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.
Tags: 2009, Animals, Bezuidenhout Lois-May, Biological Transport/drug effects, Buffers, Calcium Channels/metabolism, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/metabolism, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, European journal of pharmacology, Extracellular Space/*drug effects/*metabolism, Geldenhuys Werner J, In Vitro Techniques, Male, Methamphetamine/pharmacology, Mice, Neostriatum/*cytology/drug effects, PC12 Cells, Perfusion, Potassium Channel Blockers/pharmacology, Potassium Channels, Potassium Chloride/pharmacology, Rats, Voltage-Gated/antagonists & inhibitors
Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases.
Tags: 2017, Animals, Cardiovascular Diseases/drug therapy/*enzymology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Discovery Today, Geldenhuys Werner J, Humans, Lin Li, Lipoprotein Lipase/chemistry/*metabolism, Metabolic Diseases/drug therapy/*enzymology, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Sadana Prabodh
mitoNEET as a novel drug target for mitochondrial dysfunction.
Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.
Tags: 2012, Animals, ATP Binding Cassette Transporter, Calorimetry, Colloids and surfaces. B, Biointerfaces, Department of Pharmaceutical Sciences, Differential Scanning, Drug Carriers/*chemical synthesis/pharmacokinetics, Drug Stability, Emulsions/chemistry, Fatty Alcohols/*chemistry, Fourier Transform Infrared, Geldenhuys Werner J, Humans, Inbred BALB C, Macrophages/*drug effects/metabolism, Member 1/metabolism, Mice, Nanoparticles/*chemistry/ultrastructure, NEOMED College of Pharmacy, Oils/chemistry, Oyewumi Moses O, Paclitaxel/pharmacokinetics, Particle Size, Polyethylene Glycols/*chemistry, Reactive Oxygen Species/metabolism, Rhodamine 123/metabolism, Spectroscopy, Subfamily B, Water/chemistry, Wehrung Daniel
Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.
Tags: *Acute lymphoblastic leukemia, *Cancer, *Co-culture model, *Lipids, *Lipoprotein lipase, *Metabolism, 2018, Amides/chemistry/metabolism/pharmacology, Antineoplastic Agents/*chemistry/metabolism/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Coculture Techniques, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dyslipidemias/complications/metabolism/pathology, Geldenhuys Werner J, Gibson Laura F, Humans, Lipoprotein Lipase/antagonists & inhibitors/*metabolism, Mesenchymal Stem Cells/cytology/metabolism, Molecular Docking Simulation, Nair Rajesh R, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Piktel Debbie, Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/pathology, Protein Binding, Protein Structure, Sadana Prabodh, Serum Albumin/chemistry/metabolism, Tertiary, Tumor
High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor.
Tags: *Cancer, *Compound library, *Kinase, *Notochord, *Phenotypic screen, *Somites, *Zebrafish, 2017, Aljammal Rowaa, Animals, Antineoplastic Agents/chemistry/pharmacology, Antitumor/methods, Benzoic Acid/chemistry/pharmacology, Bergeron Sadie A, Bioorganic & medicinal chemistry letters, Chen Wei-Chi, Death-Associated Protein Kinases/metabolism, Department of Integrative Medical Sciences, Drug Discovery/*methods, Drug Screening Assays, Embryo, Enzyme Activation/drug effects, Enzyme Activators/*chemistry/*pharmacology, Gaasch Briah L, Geldenhuys Werner J, Hazlehurst Lori A, Mullins Jackie E, NEOMED College of Medicine, Neoplasms/drug therapy/enzymology, Nonmammalian/*drug effects/enzymology, Protein Kinase Inhibitors/*chemistry/*pharmacology, Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Yun June, Zebrafish Proteins/antagonists & inhibitors/metabolism, Zebrafish/*embryology
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship