Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.

Title

Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.

Creator

Geldenhuys Werner J; Hanif Ahmad; Yun June; Nayeem Mohammed A

Publisher

Molecules (Basel, Switzerland)

Date

2017
2017-06

Description

Cardiovascular diseases remain the number one diseases affecting patients' morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity.

Subject

Humans; Animals; Protein Binding; Signal Transduction; atherosclerosis; *Drug Discovery; *Ligands; Adenosine/metabolism; cardiac death; Cardiovascular Diseases/drug therapy/metabolism; Cardiovascular System/metabolism; Hydrogen Bonding; Molecular Structure; myocardial infarction; Structure-Activity Relationship; vascular tone; Receptors; Models; Molecular; Purinergic P1/*chemistry/*metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Issue

6

Volume

22

Citation

Geldenhuys Werner J; Hanif Ahmad; Yun June; Nayeem Mohammed A, “Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.,” NEOMED Bibliography Database, accessed January 17, 2021, https://neomed.omeka.net/items/show/5155.

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