Browse Items (18 total)
- Tags: Structure-Activity Relationship
TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).
Tags: *Disease Susceptibility, *Signal Transduction, 2018, Animals, Carrier Proteins/chemistry/genetics/*metabolism, Gene Expression Regulation, Humans, Hussein Nazar J, International journal of molecular medicine, Mbimba Thomas, Najeed Ayesha, Protein Binding, Protein Interaction Domains and Motifs, Protein Transport, Safadi Fayez F, Structure-Activity Relationship
Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines.
Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo.
Tags: 1990, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Alkaloids/*pharmacology, Amphetamine/*pharmacology, Animals, Brain/drug effects/*metabolism, Caudate Nucleus/metabolism, Dopamine/*metabolism, Homovanillic Acid/metabolism, Inbred Strains, Kinetics, Male, Molecular Structure, Neuropharmacology, Nucleus Accumbens/metabolism, Pehek E A, Psychotropic Drugs/*pharmacology, Putamen/metabolism, Rats, Reference Values, Schechter M D, Structure-Activity Relationship, Yamamoto B K
Antitumor effect of novel silatranes on renal cell carcinoma in mice.
Tags: *Bridged Bicyclo Compounds, *Organosilicon Compounds, 1992, Animals, Anticancer research, Antineoplastic Agents/pharmacology/*therapeutic use, Bridged Bicyclo Compounds/pharmacology/*therapeutic use, Carcinoma, Female, Grna A, Heterocyclic, Hogan J, Inbred BALB C, Kidney Neoplasms/*drug therapy, Koo P H, Mice, Renal Cell/*drug therapy, Silicon/pharmacology/*therapeutic use, Structure-Activity Relationship
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases.
Tags: *drug discovery, *Ligands, 2017, Adenosine/metabolism, Animals, Atherosclerosis, Cardiac death, Cardiovascular Diseases/drug therapy/metabolism, Cardiovascular System/metabolism, Department of Integrative Medical Sciences, Geldenhuys Werner J, Hanif Ahmad, Humans, Hydrogen Bonding, Models, Molecular, Molecular Structure, Molecules (Basel, Switzerland), myocardial infarction, Nayeem Mohammed A, NEOMED College of Medicine, Protein Binding, Purinergic P1/*chemistry/*metabolism, Receptors, Signal Transduction, Structure-Activity Relationship, Vascular tone, Yun June
The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.
Tags: 2009, Alzheimer Disease/*complications, Animals, Biological, Cognition Disorders/*drug therapy/*etiology, Drug Design, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, Models, Receptors, Serotonin Antagonists/chemistry/*therapeutic use, Serotonin/*metabolism, Structure-Activity Relationship, Van der Schyf Cornelis J
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Tags: 2004, Animals, Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism, Central Nervous System Stimulants/poisoning, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Humans, Male, Methamphetamine/*poisoning, Mice, Mutation, Neuroscience letters, Neurotoxicity Syndromes/*etiology/*metabolism, Sex Factors, Structure-Activity Relationship, Substantia Nigra/drug effects/metabolism, Transgenic
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship
Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway.
Tags: 2014, Alazizi Adnan, Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Antitumor, AXL, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Resistance, Drug Screening Assays, Gallium, Gallium-resistance, Gallium/pharmacology, Geldenhuys Werner J, Humans, Lin Li, Liva Sophia, Lung cancer, Lung Neoplasms/drug therapy/*enzymology/*pathology, Molecular Structure, Naphthalenes/chemistry/*pharmacology, NEOMED College of Pharmacy, Neoplasm/drug effects, Oyewumi Moses O, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Pyrazoles/chemistry/*pharmacology, Quinolines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Structure-Activity Relationship, Tetrazoles/chemistry/*pharmacology, Tumor, Virtual screening
A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.
Tags: *Monoamine Oxidase/chemistry/metabolism, 2012, Benzofurans/chemistry/pharmacology, Bioorganic & medicinal chemistry letters, Carroll Richard T, Enzyme Activation/drug effects, Flavonoids/chemistry/pharmacology, Funk Max O, Geldenhuys Werner J, Humans, Inhibitory Concentration 50, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/*chemistry/*pharmacology, Protein Binding/drug effects, Small Molecule Libraries, Structure-Activity Relationship, Van der Schyf Cornelis J
A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.
Tags: 2011, Awale Prabha S, Binding Sites/drug effects, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Funk Max O, Geldenhuys Werner J, Ligands, Lin Li, Mitochondrial Proteins/*antagonists & inhibitors/metabolism, Molecular Structure, Recombinant Proteins/antagonists & inhibitors/metabolism, Rosiglitazone, Stereoisomerism, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Tags: 2011, Animals, Awale Prabha S, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dluzen Dean E, Funk Max O, Geldenhuys Werner J, Humans, Inbred C57BL, Male, Mice, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/chemical synthesis/chemistry/*pharmacology, Monoamine Oxidase/*metabolism, Stereoisomerism, Stinnett Hilary, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.
Tags: 2010, Bioorganic & medicinal chemistry letters, Carroll Richard T, Darvesh Altaf S, Department of Pharmaceutical Sciences, Funk Max O, Geldenhuys Werner J, Models, Molecular, Monoamine Oxidase Inhibitors/chemistry/*pharmacology, Monoamine Oxidase/*drug effects, NEOMED College of Pharmacy, Structure-Activity Relationship, Van der Schyf Cornelis J
Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.
Tags: *Drug Design, 2010, Animals, Barnes Kendra F, Binding Sites/drug effects/physiology, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Drug Delivery Systems/*methods, Funk Max O, Geldenhuys Werner J, Liver/drug effects/metabolism, Mitochondria, Mitochondrial Proteins/*metabolism, Protein Structure, Rats, Secondary, Structure-Activity Relationship, Thiazolidinediones/administration & dosage/*chemical synthesis/*metabolism
Structure-activity relationships of pentacycloundecylamines at the
Tags: 2007, Amines/chemical synthesis/chemistry/*pharmacology, Animals, Bioorganic & medicinal chemistry, Bloomquist Jeffrey R, Brain/drug effects, Dizocilpine Maleate/pharmacology, Excitatory Amino Acid Antagonists/*pharmacology, Geldenhuys Werner J, Inbred ICR, Ion Channels, Malan Sarel F, Male, Mice, Models, Molecular, N-Methyl-D-Aspartate/*antagonists & inhibitors, Phencyclidine/analogs & derivatives, Piperidines/pharmacology, Radioligand Assay, Receptors, Structure-Activity Relationship, Synaptosomes/*drug effects, Thiophenes/pharmacology, Van der Schyf Cornelis J
The antiviral activity of RNA-dye combinations.
Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.
Tags: 2016, Alicyclic/chemical synthesis/*chemistry/pharmacology, Amines/chemical synthesis/*chemistry/pharmacology, Animals, Apoptosis/drug effects, Archiv der Pharmazie, Calcium Channel Blockers/chemical synthesis/*chemistry/pharmacology, Calcium Channels, Calcium/*metabolism, Cell Survival/drug effects, Domingo Olwen C, Geldenhuys Werner J, Hydrocarbons, Hydrogen Peroxide/pharmacology, L-Lactate Dehydrogenase/metabolism, L-type calcium channel (LTCC) blockers, L-Type/*metabolism, Malan Sarel F, Multifunctional drugs, Neurodegeneration, PC12 Cells, Pentacycloundecylamine, Quinones/chemical synthesis/*chemistry/pharmacology, Rats, Structure-Activity Relationship, Triquinylamine, Van der Schyf Cornelis J, Young Lois-May