Browse Items · NEOMED Bibliography Database

Assessing chondrocyte status by immunofluorescence-mediated localization of parkin relative to mitochondria.

Immunofluorescence staining is a widely used and powerful tool for the visualization and colocalization of two or more proteins and/or cellular organelles. For colocalization studies in fixed cells, one target protein/organelle is immunostained and…

Stem Cell Therapies For Coronary Collateral Growth In Zucker Obese Fatty Rats: Redox Modulator Mitoneet As A Therapeutic Target

Tags: 2013, Arteriogenesis, Cardiovascular System & Cardiology, Carroll R, Cells, Chilian W, Circulation, Enrick M, Geldenhuys W, Journal Article or Conference Abstract Publication, Logan S, Metabolic syndrome, Mitochondria, Ohanyan V, Oxidative Stress, Stem, Stevanov K, Yin L Y

Decreased Energy Capacity And Increased Autophagic Activity In Optic Nerve Axons With Defective Anterograde Transport

PURPOSE. Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally differentiated cells like neurons manage cytoskeletal and organelle turnover. How autophagy relates to associated neurodegenerative pathologies…

Mitochondrial Reductive Stress Induced By Over-expression Of Sod2 Enhances Cardiac Function

Tags: 2013, Cardiovascular System & Cardiology, Chen C L, Chen Y R, Chilian W M, Circulation, Hypertrophy, Journal Article or Conference Abstract Publication, Kang P T, Luther D J, Meszaros J G, Mitochondria, Ohanyan V, Oxidative Stress, Redox, Super oxide

Defective Glutathione Reductase Results In Systolic Dysfunction Associated With Impaired Mitochondrial Integrity, Increased Uncoupling Respiration, And Enhanced S-glutathionylation Of Complex I

Tags: 2011, Cardiovascular System & Cardiology, Chen C L, Chen Y R, Circulation, Enzyme inhibitors, Guarini G, Journal Article or Conference Abstract Publication, Kang P T, Mitochondria, Oxidative Stress, Redox, Systole

Oxidant Stress-induced Protein Thiyl Radical Is Associated To Enhancement Of Complex I S-glutathionylation In The Enos(-/-) Murine Heart

Tags: 2012, Cardiovascular System & Cardiology, Chen C L, Chen Y R, Circulation, Journal Article or Conference Abstract Publication, Kang P T, Mitochondria, Myocardium, nitric-oxide synthase, Redox, Super oxide

Potentiation Of The Antiviral Activity Of Poly R(a-u) By Xanthene Dyes

Tags: 1990, Cell Biology, Cell biology international reports, flow-cytometry, Hatwalkar A, inducers, inhibition, interferon, Jamison E, Jamison J M, Journal Article or Conference Abstract Publication, Krabill K, living cells, localization, Mitochondria, nucleic-acids, protein-synthesis, rhodamine-123, Tsai C C

Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma

Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even…

Excess no predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical

Mitochondria-derived oxygen-free radical(s) are important mediators of oxidative cellular injury. It is widely hypothesized that excess NO enhances O(2)(center dot-) generated by mitochondria under certain pathological conditions. In the…

THE ROLE OF PIOGLITAZONE, mitoNEET AND MITOCHONDRIA IN TBI

Tags: 2012, Carroll R T, Geldenhuys W J, General & Internal Medicine, Journal Article, Journal of neurotrauma, Mitochondria, mitoNEET, Neuroprotection, Neurosciences & Neurology, pioglitazone, Sullivan P G, TBI, Yonutas H M

AN INVESTIGATION INTO THE ROLE OF MITONEET AND MITOCHONDRIAL BIOENERGETICS IN PIOGLITAZONE MEDIATED NEUROPROTECTION FOLLOWING TBI

Tags: 2013, Carroll R T, Geldenhuys W J, General & Internal Medicine, Journal Article, Journal of neurotrauma, Mitochondria, Mitochondrial dysfunction, Neuroprotection, Neurosciences & Neurology, pioglitazone, Sullivan P G, Traumatic brain injury, Yonutas H M

INTERACTIONS BETWEEN PIOGLITAZONE AND MITONEET AMELIORATE MITOCHONDRIAL DYSFUNCTION FOLLOWING TRAUMATIC BRAIN INJURY

Tags: 2014, Carroll R T, Controlled Cortical Impact, Geldenhuys W J, General & Internal Medicine, Journal Article, Journal of neurotrauma, Mitochondria, mitoNEET, Neurosciences & Neurology, Pandya J D, pioglitazone, Sebastian A H, Sullivan P G, Traumatic brain injury, Yonutas H M

A "NEET'' MITOCHONDRIAL TARGET FOR TBI: THE IMPORTANCE OF MITONEET IN PIOGLITAZONE MEDIATED NEUROPROTECTION

Tags: (CCI), 2015, Carroll R, Controlled Cortical Impact, Geldenhuys W, General & Internal Medicine, Journal Article, Journal of neurotrauma, Mitochondria, mitoNEET, Neurosciences & Neurology, NL-1, Pandya J, pioglitazone, Sebastian A, Sullivan P, Yontuas H

Rotenone-Induced Mitochondrial Oxidative Stress Corrupts Tube Formations in Human Coronary Artery Endothelial Cells by Inhibiting mTOR Signaling Pathway

Tags: 2010, angiogenesis, Cardiovascular System & Cardiology, Chilian W M, Circulation, Journal Article, Kolz C, Mitochondria, Oxidative Stress, Pung Y F

Endothelial Knockout of Polycystin 1 (PC1) Alters Mitochondrial Functions and Bioenergetics

Tags: 2012, Adapala R K, Burke J R, Cardiovascular System & Cardiology, Chilian W M, Circulation, Disease, Endothelial, Geldenhuys W J, Jones T J, Journal Article, Mitochondria, Pung Y F, Reactive oxygen intermediates, Thodeti C K, Vascular

Mitochondrial Transfer Restores Endothelial Dependent Vasodilation

Tags: 2012, blood-flow, Cardiovascular System & Cardiology, Chen C L, Chen Y R, Chilian W, Circulation, Endothelium, Guarini G, Hardwick J P, Journal Article, Kolz C L, Logan S, Mitochondria, nitric-oxide, Ohanyan V A, Pung Y F, Vascular disease, Yin L Y

Simplified method for concentration of mitochondrial membrane protein complexes

Extracting and concentrating mitochondrial protein complexes from gel strips after blue native PAGE (BN-PAGE) can be daunting tasks using the traditional methods, such as electroelution, passive diffusion and centrifugal concentration. We present a…

Tags: 2010, Angelos M G, Biochemistry & Molecular Biology, blue, Blue native PAGE, Chemistry, Chen Y R, Complex I, Electrophoresis, Electrophoretic concentration, Journal Article, Mitochondria, native electrophoresis, oxidative-phosphorylation, polyacrylamide-gels, sds-page, Yeh S T

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve.

Metabolic dysfunction accompanies neurodegenerative disease and aging. An important step for therapeutic development is a more sophisticated understanding of the source of metabolic dysfunction, as well as to distinguish disease-associated changes…

Tags: 2019, Chen Yeong-Renn, Coughlin Lucy, DBA/2J, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Fluorocitrate, Glaucoma, Harun-Or-Rashid Mohammad, Inman Denise M, Jassim Assraa Hassan, Kang Patrick T, Mitochondria, Molecular neurobiology, NEOMED College of Medicine, NEOMED College of Pharmacy, optic nerve, Seahorse analyzer

Corruption of coronary collateral growth in metabolic syndrome: Role of oxidative stress.

The myocardium adapts to ischemic insults in a variety of ways. One adaptation is the phenomenon of acute preconditioning, which can greatly ameliorate ischemic damage. However, this effect wanes within a few hours and does not confer chronic…

Tags: 2010, angiogenesis, Arteriogenesis, Chilian William M, Department of Integrative Medical Sciences, Mitochondria, NEOMED College of Medicine, Pung Yuh Fen, Redox-dependent signaling, World journal of cardiology

Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.

HDL and apolipoprotein A1 (apoA1) concentrations inversely correlate with risk of death from ischemic heart disease; however, the role of apoA1 in the myocardial response to ischemia has not been well defined. To test whether apoA1, the primary HDL…

Tags: *Disease Models, 2014, Animal, Animal Studies, Animals, Antioxidants – Administration and Dosage, Antioxidants – Metabolism, Antioxidants – Pharmacokinetics, Antioxidants – Therapeutic Use, Antioxidants/administration & dosage/*metabolism/pharmacokinetics/therapeutic use, Apolipoprotein A-I/blood/genetics/*metabolism, Apolipoproteins, Apolipoproteins – Blood, Apolipoproteins – Metabolism, Biological, Cardiotonic Agents – Administration and Dosage, Cardiotonic Agents – Metabolism, Cardiotonic Agents – Pharmacokinetics, Cardiotonic Agents – Therapeutic Use, Cardiotonic Agents/administration & dosage/metabolism/pharmacokinetics/therapeutic use, Coenzyme Q, Coenzyme Q – Administration and Dosage, Coenzyme Q – Metabolism, Coenzyme Q – Pharmacokinetics, Coenzyme Q – Therapeutic Use, Dadabayev Alisher R, Dietary Supplements, Electron Transport – Drug Effects, Electron Transport Complex II/chemistry/metabolism, Electron Transport Complex III/chemistry/metabolism, Electron Transport/drug effects, Heart – Drug Effects, Heart/drug effects, Heart/drug effects/enzymology/*metabolism, Hypoalphalipoproteinemias/physiopathology, Inborn Errors – Physiopathology, Injections, Intestinal Absorption, Intraperitoneal, Knockout, Latchoumycandane Calivarathan, Lesnefsky Edward J, Lipid Metabolism, Male, McIntyre Thomas M, Mice, Mitochondria, Mitochondria – Drug Effects, Mitochondria – Metabolism, Models, Myocardial Infarction – Etiology, Myocardial Infarction – Metabolism, Myocardial Infarction – Pathology, Myocardial Infarction – Therapy, Myocardial Infarction/etiology/metabolism/pathology/*therapy, Myocardial Reperfusion Injury – Blood, Myocardial Reperfusion Injury – Metabolism, Myocardial Reperfusion Injury – Pathology, Myocardial Reperfusion Injury – Prevention and Control, Myocardial Reperfusion Injury/blood/metabolism/pathology/prevention & control, Myocardium, Myocardium – Metabolism, Myocardium – Pathology, Myocardium/enzymology/*metabolism/pathology, Penn Marc S, Proteins, Proteins – Metabolism, The Journal of nutrition, Tissue Distribution, Ubiquinone/administration & dosage/*analogs & derivatives/metabolism/pharmacokinetics/therapeutic use, Yin Guotian

The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance.

Aging is associated with the accumulation of various deleterious changes in cells. According to the free radical and mitochondrial theory of aging, mitochondria initiate most of the deleterious changes in aging and govern life span. The failure of…

Tags: 2014, Abadir Peter, Aging, angiotensin II, angiotensin II type 1 receptor blockers, Frailty, Frontiers in physiology, Mitochondria, mitochondrial angiotensin system, Redox regulation, Rini David, Vajapey Ramya, Walston Jeremy

Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve.

PURPOSE: Decreased ATP correlates with intraocular pressure exposure in the optic nerves of mice with glaucoma. To understand what underlies this energy deficit, we examined mitochondria in the myelinated optic nerve axons of the DBA/2J mouse, a…

Cardiac mitochondria and reactive oxygen species generation.

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cardiovascular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by the…

Tags: 2014, Animals, Cardiac/*metabolism, Cardiovascular Diseases/*metabolism, Chen Yeong-Renn, Circulation research, Department of Integrative Medical Sciences, electron transport chain complex proteins, Heart/*metabolism, Humans, Membrane Potentials/physiology, Mitochondria, myocardial infarction, Myocytes, NEOMED College of Medicine, reactive oxygen species, Reactive Oxygen Species/*metabolism, Signal Transduction/physiology, Zweier Jay L

Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.

OBJECTIVE: Our goal was to determine the mechanism by which mitochondrial oxidative stress impairs collateral growth in the heart. APPROACH AND RESULTS: Rats were treated with rotenone (mitochondrial complex I inhibitor that increases reactive oxygen…

Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya

Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.

OBJECTIVE: We have previously found abrogated ischemia-induced coronary collateral growth in Zucker obese fatty (ZOF) rats compared with Zucker lean (ZLN) rats. Because ZOF rats have structural abnormalities in their mitochondria suggesting…

Tags: 2012, Animal, Animals, Antioxidants/*pharmacology, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Collateral Circulation/*drug effects/physiology, Coronary Vessels/drug effects/*growth & development, Department of Integrative Medical Sciences, Disease Models, Guarini Giacinta, Hafemeister Jennifer, Heart/*drug effects/physiology, Lipid Peroxidation/drug effects/physiology, Lipid Peroxides/metabolism, Male, Metabolic Syndrome/*metabolism/physiopathology, Mitochondria, Mitochondrial Proteins/metabolism, Murphy Michael P, NEOMED College of Medicine, Obesity/*metabolism/physiopathology, Ohanyan Vahagn, Organophosphorus Compounds/pharmacology, Oxidative Stress/*drug effects/physiology, Piperidines/pharmacology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Rocic Petra, Smith Robin A J, Ubiquinone/pharmacology, Yin Liya, Zucker

The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth.

Coronary collateral growth is a process involving coordination between growth factors expressed in response to ischemia and mechanical forces. Underlying this response is proliferation of vascular smooth muscle and endothelial cells, resulting in an…

Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress.

KEY POINTS: Hyperammonaemia occurs in hepatic, cardiac and pulmonary diseases with increased muscle concentration of ammonia. We found that ammonia results in reduced skeletal muscle mitochondrial respiration, electron transport chain complex I…

Tags: *ammonia, *ATP, *cellular respiration, *cirrhosis, *Mitochondria, *Oxidative Stress, *portacaval anastamosis, *Reactive oxygen species, *skeletal muscle, 2016, Adenosine Triphosphate/metabolism, Aged, Allawy Allawy, Animals, Cell Line, Cell Respiration, Creatine Kinase/metabolism, Dasarathy Srinivasan, Davuluri Gangarao, Department of Pharmaceutical Sciences, Female, Flask Chris A, Hoppel Charles, Humans, Hyperammonemia/*metabolism, Kasumov Takhar, Kumar Avinash, Liver Cirrhosis/metabolism, Male, Middle Aged, Mitochondria, Muscle, Muscle/*metabolism, Myosin Heavy Chains/metabolism, NAD/metabolism, NEOMED College of Pharmacy, Rats, Reactive Oxygen Species/metabolism, Rennison Julie H, Sandlers Yana, Singh Dharmvir, Skeletal/*metabolism, Sprague-Dawley, Thapaliya Samjhana, The Journal of physiology, Thiobarbituric Acid Reactive Substances/metabolism, Van Wagoner David R

Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.

During heightened cardiac work, O2 consumption by the heart benefits energy production via mitochondria. However, some electrons leak from the respiratory chain and yield superoxide, which is rapidly metabolized into H2O2 by SOD2. To understand the…

Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects

Increased mitochondrial prooxidant activity mediates up-regulation of Complex I

In response to oxidative stress, mitochondrial Complex I is reversibly

Protein thiyl radical mediates S-glutathionylation of complex I.

Complex I is a critical site of O(2)(*-) production and the major host of reactive protein thiols in mitochondria. In response to oxidative stress, complex I protein thiols at the 51- and 75-kDa subunits are reversibly

Tags: *Oxidative Stress, 2012, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cattle, Cell Line, Chen Chwen-Lih, Chen Jingfeng, Chen Yeong-Renn, Cyclic N-Oxides/chemistry/pharmacology, Cysteine/chemistry/*metabolism, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Free radical biology & medicine, Free Radical Scavengers/chemistry/pharmacology, Free Radicals/chemistry/*metabolism, Glutathione/chemistry/*metabolism, Green Kari B, Heart/enzymology/metabolism, Kang Patrick T, Mice, Mitochondria, Models, Molecular, Molecular Sequence Data, Muscle Cells/drug effects/metabolism, NEOMED College of Medicine, Onium Compounds/pharmacology, Peptide Fragments/chemistry, Peptide Mapping, Protein, Rats, Rotenone/pharmacology, Structural Homology, Superoxides/metabolism, Zhang Liwen

Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.

Several PPAR-gamma agonists containing a thiazolidinedione moiety (referred to as glitazones) have been proposed to be neuroprotective and appear to alter mitochondrial function. Recently, a search for mitochondrial proteins that bind pioglitazone…

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known…

Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction

Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.

The mitochondrial electrochemical gradient (Deltap), which comprises the pH gradient (DeltapH) and the membrane potential (DeltaPsi), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial…

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we…

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