Browse Items · NEOMED Bibliography Database

Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation in rats with metabolic syndrome

Endothelial dysfunction in diabetes is generally attributed to oxidative stress, but this view is challenged by observations showing antioxidants do not eliminate diabetic vasculopathy. As an alternative to oxidative stress-induced dysfunction, we…

Tags: 2022, Diabetes, endothelial dysfunction, Endothelium, Metabolic syndrome, Mitochondria.

Step by Step: Advancing the Understanding of Local Vascular Control.

Tags: 2020, and vascular biology, Arterial Pressure, Arteriosclerosis, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Department of Integrative Medical Sciences, dilation, Editorials, Endothelium, hypoxia, NEOMED College of Medicine, Ohanyan Vahagn, Thrombosis, vasodilation, Yin Liya

Role Of Genetic Polymorphisms Of Ion Channels In The Pathophysiology Of Coronary Microvascular Dysfunction And Ischemic Heart Disease

Kallistatin is a potent new vasodilator

Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its activity, The aim of this study is to evaluate if kallistatin has a direct effect on the vasculature and on blood pressure homeostasis. We found that an…

Mitochondrial Transfer Restores Endothelial Dependent Vasodilation

Tags: 2012, blood-flow, Cardiovascular System & Cardiology, Chen C L, Chen Y R, Chilian W, Circulation, Endothelium, Guarini G, Hardwick J P, Journal Article, Kolz C L, Logan S, Mitochondria, nitric-oxide, Ohanyan V A, Pung Y F, Vascular disease, Yin L Y

Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta

Contractions of rat thoracic aorta to vasopressin WP) are threefold higher in females (F) than in males (M), primarily because nitric oxide (NO) attenuation of contraction is greater in M. To determine the role of the androgen receptor (AR) in this…

coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.

The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary occlusion, and this occlusion must be removed to induce reperfusion.…

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function.

Endothelial nitric oxide synthase (eNOS) is critical in the regulation of vascular function, and can generate both nitric oxide (NO) and superoxide (O2•−), which are key mediators of cellular signalling. In the presence of Ca2+/calmodulin, eNOS…

Ultrastructural immunolocalization of the atrial natriuretic factor pathways in fetal, neonatal, and adult Syrian hamsters: from the atrial cardiomyocytes to the circulation via the endocardium, atrial capillaries and epicardium.

Atrial natriuretic factor (ANF)-immunoreactivity was identified with peroxidase-antiperoxidase staining and immunoelectron microscopic gold labeling techniques in atrial tissues of fetal, newborn and adult Syrian hamsters.

Tags: 1991, Aging/*metabolism, Animals, Atrial Natriuretic Factor/*metabolism, Capillaries/cytology/metabolism/ultrastructure, Cricetinae, Endocardium/cytology/metabolism/ultrastructure, Endothelium, Gilloteaux J, Immunoelectron, Jennes L, Journal of submicroscopic cytology and pathology, Menu R, Mesocricetus, Microscopy, Myocardium/metabolism/*ultrastructure, Newborn/*metabolism, Vanderhaeghen J J, Vascular/cytology/metabolism/ultrastructure

Testosterone causes direct relaxation of rat thoracic aorta.

Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic…

A bouquet for a broken heart: can flowers repair a damaged heart?

Tags: 2015, angiogenesis, Animals, Circulation research, Coronary Vessels, Coronary Vessels/*physiopathology, Department of Integrative Medical Sciences, Editorials, endocardium, Endocardium/*physiopathology, endothelial cells, Endothelium, myocardial infarction, Myocardial Infarction/*physiopathology, NEOMED College of Medicine, Thodeti Charles K, Vascular/*physiopathology

Connecting the dots–establishing causality between chronic stress, depression, and cardiovascular disease.

Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung.

To determine the correlation between ultrastructural and physiological changes in blood-gas barrier function in lungs transiently exposed to very high vascular pressures, we increased capillary transmural pressure (Ptm) of 6 canine isolated perfused…

RNA interference for alpha-ENaC inhibits rat lung fluid absorption in vivo.

We used siRNA against the alpha-ENaC (epithelial Na channel) subunit to investigate ENaC involvement in lung fluid absorption in rats by the impermeable tracer technique during baseline and after beta-adrenoceptor stimulation by terbutaline.…

Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta.

In rat thoracic aorta, contractile responses to arginine vasopressin (AVP) are twofold higher in females than in males. To determine the role of the endothelium in this phenomenon, the effects of endothelium removal and inhibition of nitric oxide…

Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids.

The effects of constrictor prostanoid (CP) pathway inhibitors on vascular reactivity to vasopressin (VP) and phenylephrine (PE) were examined in thoracic aortas of male, female, and ovariectomized (OVX) female Sprague-Dawley rats. Maximal contractile…

Thrombospondin-4 mediates TGF-beta-induced angiogenesis.

TGF-beta is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-beta signaling are process-and stage-dependent, and it is not…

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