Browse Items · NEOMED Bibliography Database

Avoiding unnecessary bronchoscopy in children with suspected foreign body aspiration using computed tomography.

BACKGROUND: Bronchoscopy is the standard of care for diagnosis and treatment of foreign body aspiration (FBA). Drawbacks of this approach include its invasiveness, the potential for exacerbation of reactive airway disease, and the need for general …

Critical Care Helicopter Overtriage: A Failure Mode and Effects Analysis.

OBJECTIVE: Overtriage (OT) of helicopter emergency medical services (HEMS) poses significant burden to multiple stakeholders. The project aims were to identify the following: 1) associated factors, 2) downstream effects, and 3) focus areas for …

Theory of Mind and Parental Nurturance as Predictors of Peer Relationships After Childhood Traumatic Brain Injury: A Test of Moderated Mediation.

OBJECTIVE: Traumatic brain injury (TBI) sustained in childhood is associated with poor social outcomes. This study investigated the role of theory of mind (ToM) as a mediator of the relation between TBI and peer rejection/victimization and …

SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis.

OBJECTIVE: The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) …

Most Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Also Have Functional Esophageal Disorders.

BACKGROUND & AIMS: As many as 45% of patients with gastroesophageal reflux disease (GERD) still have symptoms after receiving once-daily proton pump inhibitor (PPI) therapy. We aimed to compare reflux characteristics and patterns between responders…

A Structured Approach for Safely Reintroducing Bariatric Surgery in a COVID-19 Environment.

Due to the profound effect of novel coronavirus disease 2019 (COVID-19) on healthcare systems, surgical programs across the country have paused surgical operations and have been utilizing virtual visits to help maintain public safety. For those…

Mucosal barrier injury-associated bloodstream infections in pediatric oncology patients.

BACKGROUND: Single-center reports of central line-associated bloodstream infection (CLABSI) and the subcategory of mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) in pediatric hematology oncology transplant (PHO) …

Mechanical Thrombectomy for Patients with In-Hospital Ischemic Stroke: A Case-Control Study.

BACKGROUND AND AIM: Patients with in-hospital acute ischemic stroke (AIS) have, in general, worse outcomes compared to those presenting from the community, partly attributed to the numerous contraindications to intravenous thrombolysis. We aimed …

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

Final Two-Year Outcomes for the Sentry Bioconvertible Inferior Vena Cava Filter in Patients Requiring Temporary Protection from Pulmonary Embolism.

PURPOSE: To report final 2-year outcomes with the Sentry bioconvertible inferior vena cava (IVC) filter in patients requiring temporary protection against pulmonary embolism (PE). MATERIALS AND METHODS: In a prospective multicenter trial, the…

Rising Prevalence of Opioid Use Disorder and Predictors for Opioid Use Disorder Among Hospitalized Patients With Chronic Pancreatitis.

OBJECTIVES: We aimed to evaluate the prevalence, impact, and predictors of opioid use disorder (OUD) in hospitalized chronic pancreatitis (CP) patients. METHODS: A retrospective cohort study was performed using the National Inpatient Sample …

Racial differences in performance-based function and potential explanatory factors among individuals with knee osteoarthritis.

Objective: In individuals with knee osteoarthritis (OA), self-reported physical function is poorer in African Americans than in whites, but whether this difference holds true for objective assessments is unclear. The purpose of this study was to…

Safety and efficacy of transcatheter aortic valve replacement for native aortic valve regurgitation: A systematic review and meta-analysis.

OBJECTIVE: The objective of this study was to analyze the available literature on using transcatheter aortic valve replacement (TAVR) for native aortic regurgitation (AR). BACKGROUND: Surgical aortic valve replacement is the gold standard therapy…

The development and evaluation of a brief form of the normative male alexithymia scale (NMAS-BF).

The current study extended prior work on the Normative Male Alexithymia Scale (NMAS), a unidimensional measure of some men's limitations in expressing emotion that results from gender-based socialization informed by the masculine norm of …

Impact of residual coronary atherosclerosis on transfemoral transcatheter aortic valve replacement.

OBJECTIVES: This study reports on the clinical effects of complete vs incompletely revascularized coronary artery disease on transcatheter aortic valve replacement (TAVR). BACKGROUND: There is a high prevalence of active coronary artery disease …

Tags: 2019, Aged, Aged 80 and over, Al-Kindi SG, Aortic Valve Stenosis/diagnostic imaging/mortality/physiopathology/surgery, Aortic Valve/diagnostic imaging/physiopathology/surgery, Attizzani GF, AVD - aortic valve disease, Bezerra HG, CAD - coronary artery disease, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Catheterization Peripheral/adverse effects/mortality, Cause of Death, Cleveland Clinic Akron General Hospital, Coronary Artery Disease/diagnostic imaging/mortality/therapy, Costa MA, Davis A, Department of Internal Medicine, Female, Femoral Artery, Hornick JM, Humans, Ichibori Y, journalArticle, June2020SubmittedList, Kalra A, Li Jun, Lipinski J, Makani A, Male, Markowitz AH, Nadeem F, NEOMED College of Medicine, Patel SM, Patel T, Patient Readmission, PCI - percutaneous coronary intervention (PCI), Percutaneous Coronary Intervention/adverse effects/mortality, percutaneous intervention, Punctures, Retrospective Studies, Risk Assessment, Risk Factors, Simon DI, Thakker P, Thomas R, Time Factors, Transcatheter Aortic Valve Replacement/adverse effects/mortality, Treatment Outcome

Outcomes with drug-coated balloons in small-vessel coronary artery disease.

BACKGROUND: Percutaneous coronary intervention (PCI) of small-vessel coronary artery disease (SVD) is associated with increased risk of restenosis. The use of drug-coated balloons (DCBs) in SVD has received limited study. OBJECTIVES: To assess the…

Tags: 2019, Abbott JD, Aged, Angioplasty Balloon Coronary/adverse effects/instrumentation/mortality, Brilakis ES, Cardiac Catheters, Cardiovascular Agents/administration & dosage/adverse effects, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Cleveland Clinic Akron General Hospital, Coated Materials Biocompatible, Coronary Artery Disease/diagnostic imaging/mortality/therapy, Coronary Restenosis/epidemiology, Department of Internal Medicine, drug-coated balloons, drug-eluting balloons, Drug-Eluting Stents, Female, Humans, journalArticle, June2020SubmittedList, Kalra A, Kohl LP, Male, Megaly M, Middle Aged, NEOMED College of Medicine, Observational Studies as Topic, Randomized Controlled Trials as Topic, Rezq A, Risk Assessment, Risk Factors, Rofael M, Saad M, Shishehbor M, small-vessel disease coronary disease, Soukas P, Treatment Outcome

Outcomes among patients with heart failure with reduced ejection fraction undergoing transcatheter aortic valve replacement: Minimally invasive strategy versus conventional strategy.

OBJECTIVES: To investigate the effect of TAVR technique on in-hospital and 30-day outcomes in patients with aortic stenosis (AS) and reduced ejection fraction (EF). BACKGROUND: Patients with AS and concomitant low EF may be at risk for adverse …

Tags: 2019, Aged, Aged 80 and over, Anesthesia, aortic stenosis, Aortic Valve Stenosis/diagnostic imaging/epidemiology/therapy, Attizzani GF, Cardiac Catheterization/methods, Cardiac Output Low/diagnostic imaging, Cleveland Clinic Akron General Hospital, Clevenger J, Cohort Studies, Conscious Sedation, Conscious Sedation/methods, Department of Internal Medicine, Echocardiography Transesophageal/methods, Female, Heart failure, Heart Failure/diagnosis/epidemiology/therapy, Hospital Mortality, Humans, journalArticle, June2020SubmittedList, Kalra A, Karim A, Length of Stay, Li J, Lipinski J, Logistic Models, Male, Minimally Invasive Surgical Procedures/methods, Multivariate Analysis, NEOMED College of Medicine, Panhwar MS, Patel SM, Patel TR, Prognosis, Reference Values, Retrospective Studies, Risk Assessment, Saric P, Severity of Illness Index, Surgery Computer-Assisted/methods, Survival Rate, The Journal of invasive cardiology, transcatheter aortic valve replacement, Transcatheter Aortic Valve Replacement/methods/mortality, Treatment Outcome, Zidar DA

Effect of influenza on outcomes in patients with heart failure.

OBJECTIVES: This study sought to determine whether influenza infection increases morbidity and mortality in patients hospitalized with heart failure (HF). BACKGROUND: Patients with HF may be at increased risk of morbidity and mortality from…

Moderation and mediation of the relationships between masculinity ideology and health status.

OBJECTIVE: The purpose of this study was to assess the direct and indirect relationships between the endorsement of traditional masculinity ideology (TMI) and self-reported health status through potential mediating variables of expectations of …

Short-term and long-term outcomes of patients undergoing urgent transcatheter aortic valve replacement under a minimalist strategy.

OBJECTIVES: Urgent transcatheter aortic valve replacement (TAVR) is associated with worse short-term outcomes compared with elective TAVR; however, little is known about long-term outcomes or the safety of the minimalist strategy in this setting. …

Tags: 2019, Aged 80 and over, Aortic Valve Stenosis/diagnosis/mortality/surgery, Aortic Valve/diagnostic imaging/surgery, Attizzani GF, Bezerra HG, Cardiac Catheterization/methods, Cleveland Clinic Akron General Hospital, Costa MA, Davis A, Department of Internal Medicine, Echocardiography Transesophageal, Elective Surgical Procedures/methods, Female, Femoral Artery, Follow-Up Studies, Hospital Mortality/trends, Humans, Ichibori Y, journalArticle, June2020SubmittedList, Kalra A, Kobe D, Ladas T, Length of Stay, Li J, Lipinski J, Male, Markowitz AH, minimalist approach, NEOMED College of Medicine, Patel S, Patel T, Peters M, Retrospective Studies, Risk Factors, Saric P, severe aortic stenosis, Severity of Illness Index, The Journal of invasive cardiology, Time Factors, transcatheter aortic valve replacement, Transcatheter Aortic Valve Replacement/methods, Treatment Outcome, Tsushima T, United States/epidemiology, urgent procedure

Relation of concomitant heart failure to outcomes in patients hospitalized with influenza.

Influenza is a major public health challenge. Patients hospitalized with influenza who also have heart failure (HF) may be at risk for worse outcomes compared with patients without HF. There is a lack of large studies examining this issue. We …

Feasibility and safety of adopting next-day discharge as first-line option after transfemoral transcatheter aortic valve replacement.

OBJECTIVES: Data on next-day discharge (NDD) after transcatheter aortic valve replacement (TAVR) are limited. This study investigated the feasibility and safety of NDD as a first-line option (the very-early discharge [VED] strategy) compared with…

Tags: 2019, Academic Medical Centers, Aged, Aged 80 and over, aortic stenosis, Aortic Valve Stenosis/diagnosis/surgery, Attizzani GF, Bezerra HG, Cleveland Clinic Akron General Hospital, Cohort Studies, Costa MA, Davis A, Department of Internal Medicine, early discharge, Feasibility Studies, Female, Follow-Up Studies, Humans, Ichibori Y, journalArticle, June2020SubmittedList, Kalra A, Length of Stay, Li J, Lipinski J, Male, Markowitz AH, minimalist approach, NEOMED College of Medicine, next-day discharge, Ohio, Panhwar M, Patel SM, Patel TM, Patient Discharge, Patient Readmission/statistics & numerical data, Patient Safety, Propensity Score, Qureshi G, Retrospective Studies, Risk Assessment, Sareyyupoglu B, Saric P, Severity of Illness Index, Survival Analysis, The Journal of invasive cardiology, Time Factors, transcatheter aortic valve replacement, Transcatheter Aortic Valve Replacement/methods/mortality, United States, Zidar DA

Stability after initial decline in coronary revascularization rates in the united states.

BACKGROUND: It remains uncertain how advances in revascularization techniques, availability of new evidence, and updated guidelines have influenced the annual rates of coronary revascularization in the United States. METHODS: We used the …

The changing landscape of aortic valve replacement in the usa.

AIMS: The aim of this study was to analyse the real-world national data on parallel utilisation of transcatheter (TAVR) and surgical (SAVR) aortic valve replacement. METHODS AND RESULTS: We queried an all-payer, administrative United States …

Results through skeletal maturity of planned fibular nonunion for the treatment of genu varum in achondroplasia: An observational retrospective study

Current surgical options for treating genu varum in achondroplasia include tibial and fibular osteotomy and growth modulation using plates and screws. However, a single surgeon consistently treated genu varum using a planned fibular nonunion (PFN).…

Syringocystadenoma papilliferum of the male breast

A 39-year-old man presented with a 2-cm, mildly tender mass in the right breast of many years' duration. Microscopic examination showed a syringocystadenoma papilliferum. Because of its location in the breast, we studied the lesion for…

Tags: 1998, American Journal of Dermatopathology, apocrine, breast, Dermatology, differentiation, eccrine differentiation, Fatteh S, GCDFP-15, Journal Article, Lopez J, lysozyme, Male, Nowak M, Pathan A, plasma cell infiltrate, syringocystadenoma papilliferum, tumors

Homozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease

Aminoacyl-tRNA synthetases (ARSs) are critical for protein translation. Pathogenic variants of ARSs have been previously associated with peripheral neuropathy and multisystem disease in heterozygotes and homozygotes, respectively. We report seven…

Tags: 2019, Adult, Antonellis Anthony, Baras Aris, Biochemistry & Molecular Biology, Brigatti Karlla W, Carson Vincent J, Catalytic Domain, Child, Demczko Matthew M, Female, Fox Michael D, Furuya Katryn N, gene, Genetic Diseases, Genetic Predisposition to Disease, Genetics & Heredity, Gonzaga-Jauregui Claudia, Griffin Laurie B, Hearing Loss, Heterozygote, Homozygote, Human molecular genetics, Humans, impairment, Inborn, Infant, Jinks Robert N, Kandula Vinay V R, lactic-acidosis, Loss of Function Mutation, Male, Martinez Erick D, mechanisms, Miles Lili, Mutation, myopathy, NEOMED College of Medicine Student, NEOMED Student Publications, Newborn, onset, Overton John D, Pedigree, Phenotype, phenotypic variability, Poskitt Laura, Preschool, Puffenberger Erik G, Radhakrishnan Kadakkal, recessive mutations, Reid Jeffrey G, Sensorineural, September 2019 Update, Severity of Illness Index, Strauss Kevin A, swiss-model, Tyrosine-tRNA Ligase, variant, Wenger Olivia K, Whole Exome Sequencing, Williams Katie B, Yeasts, Yoder Mark A

Olmesartan Associated Enteropathy: A Rare Underdiagnosed Cause of Diarrhea and Weight Loss.

BACKGROUND Olmesartan, an angiotensin receptor blockade class of antihypertensive medication has recently been associated with a seronegative sprue like enteropathy. Patients typically present with diarrhea and weight loss often prompting exhaustive…

Tags: *Weight Loss, 2019, Antihypertensive Agents/*adverse effects, Colitis, Department of Internal Medicine, Diarrhea/*chemically induced, Gonakoti Sripriya, Humans, Imidazoles/*adverse effects, Khullar Sanjiv, Lymphocytic/*chemically induced, Male, Middle Aged, NEOMED College of Medicine, Rajkumar Aarthi, Tetrazoles/*adverse effects, The American journal of case reports, Vomiting/*chemically induced

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.

BACKGROUND: Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson's disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein…

Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease.

BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population.…

Exploring comorbid depression and physical health trajectories: A case-based computational modelling approach.

While comorbid depression/physical health is a major clinical concern, the conventional methods of medicine make it difficult to model the complexities of this relationship. Such challenges include cataloguing multiple trends, developing multiple…

Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.

Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTRs). We found that CysLT2R regulates angiogenesis in isolated mouse endothelial cells (ECs) and in Matrigel implants in…

Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Animals, Austen K Frank, Capillary Permeability/drug effects, Cyclohexanecarboxylic Acids/pharmacology, Department of Integrative Medical Sciences, Duah Ernest, Endothelial Cells/*drug effects, Experimental, Gene Knockout Techniques, Inbred C57BL, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, Leukotriene Antagonists/pharmacology, Leukotriene/drug effects/*metabolism, Lung Neoplasms/drug therapy, Male, Mice, NEOMED College of Medicine, Neoplasm Metastasis/drug therapy, Neoplasm Transplantation, Neoplasms, Neovascularization, Paruchuri Sailaja, Pathologic/*chemically induced/drug therapy, Phthalic Acids/pharmacology, Proceedings of the National Academy of Sciences of the United States of America, Receptors, Teegala Lakshminarayan Reddy, Thodeti Charles K

Nodes of Ranvier in Glaucoma.

Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon…

The effect of manganese exposure in Atp13a2-deficient mice.

Loss of function mutations in the P5-ATPase ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis. While the function of ATP13A2 is unclear, in vitro studies suggest it is a lysosomal protein that interacts with the…

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.

OBJECTIVES: Activation of the bile acid (BA) receptors farnesoid X receptor (FXR) or G protein-coupled bile acid receptor (GPBAR1; TGR5) improves metabolic homeostasis. In this study, we aim to determine the impact of pharmacological activation of…

Editorial Comment.

Tags: *Elasticity Imaging Techniques, *Prostatic Neoplasms, 2018, Barr Richard G, Humans, Male, Prospective Studies, The Journal of urology

Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.

The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited…

The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.

Parkinson's disease (PD), the second most common age-related progressive neurodegenerative disorder, is characterized by dopamine depletion and the loss of dopaminergic (DA) neurons with accompanying neuroinflammation. Zonisamide is…

Exploring the role of YouTube in delivering dementia education to older Chinese.

Tags: *Geriatric Assessment, *Social Media, 2018, Aged, Asian journal of psychiatry, China, Dementia/*psychology, Female, Health Education/*methods, Humans, Internet, Lam Nikki H T, Male, Middle Aged, Woo Benjamin K P

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Bile acids activate farnesoid X receptor (FXR) and G protein-coupled bile acid receptor-1 (aka Takeda G protein-coupled receptor-5 [TGR5]) to regulate bile acid metabolism and glucose and insulin sensitivity. FXR and TGR5 are coexpressed in the…

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