Browse Items (84 total)
- Tags: Inbred C57BL
Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.
Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Animals, Austen K Frank, Capillary Permeability/drug effects, Cyclohexanecarboxylic Acids/pharmacology, Department of Integrative Medical Sciences, Duah Ernest, Endothelial Cells/*drug effects, Experimental, Gene Knockout Techniques, Inbred C57BL, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, Leukotriene Antagonists/pharmacology, Leukotriene/drug effects/*metabolism, Lung Neoplasms/drug therapy, Male, Mice, NEOMED College of Medicine, Neoplasm Metastasis/drug therapy, Neoplasm Transplantation, Neoplasms, Neovascularization, Paruchuri Sailaja, Pathologic/*chemically induced/drug therapy, Phthalic Acids/pharmacology, Proceedings of the National Academy of Sciences of the United States of America, Receptors, Teegala Lakshminarayan Reddy, Thodeti Charles K
Nodes of Ranvier in Glaucoma.
Tags: *Axonopathy, *axons, *neurodegeneration, *neurofilament, *node of Ranvier, *superior colliculus, 2018, Action Potentials, Animals, Axons/pathology, Crish S D, Cytoskeleton/pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Female, Glaucoma/metabolism/pathology/*physiopathology, Inbred C57BL, Male, Meier J, Mice, NEOMED College of Pharmacy, Neuroscience, Optic Nerve/metabolism/pathology, Plyler E S, Ranvier's Nodes/*physiology/ultrastructure, Smith M A, Transgenic, Visual Pathways/metabolism/*physiopathology/ultrastructure, Voltage-Gated Sodium Channels/metabolism
The effect of manganese exposure in Atp13a2-deficient mice.
Tags: *Alpha-synuclein, *Lipofuscin, *Manganese, *Parkinson's disease, *Sensorimotor function, 2018, Adenosine Triphosphatases/genetics/*metabolism, Aga Diana S, alpha-Synuclein/metabolism, Animal, Animals, Behavior, Brain/*drug effects/*metabolism, Department of Pharmaceutical Sciences, Ekhator Osunde R, Female, Fleming Sheila M, Holden John G, Inbred C57BL, Karkare Swagata, Knockout, Lemkuhl Andrew, Linn Stephen C, Liou Benjamin, Male, Manganese/metabolism/*toxicity, Membrane Proteins/genetics/*metabolism, Mice, Motor Activity, Mullin Elizabeth J, NEOMED College of Pharmacy, Neurotoxicology, Pamphile Shanta, Roth Jerome A, Santiago Nicholas A, Schultheis Patrick J, Shull Gary E, Sun Ying
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Animals, Bile Acids and Salts/pharmacology/*therapeutic use, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet, G-Protein-Coupled/*agonists, Hep G2 Cells, High-Fat/adverse effects, Humans, Hypercholesterolemia/*drug therapy/etiology/metabolism, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Lee Yoon Kwang, Li Yuanyuan, Male, Mice, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*drug therapy/etiology/metabolism, Obesity/*drug therapy/etiology/metabolism, Receptors, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Tags: 2018, Administration, Alboslemy Talib, Animal, Animals, Cell Communication/*physiology, Cell Differentiation, Cells, Cultured, Cutaneous, Diabetes Mellitus, Disease Models, Eye Proteins/administration & dosage/genetics/*physiology, Humans, Inbred C57BL, Kim Min-Ho, Macrophages/*physiology, Male, Membrane Glycoproteins/administration & dosage/genetics/*physiology, Mesenchymal Stem Cells/*physiology, Mice, Recombinant Proteins/administration & dosage/genetics/metabolism, Safadi Fayez, Skin/*injuries/metabolism, The Journal of investigative dermatology, Type 2/complications/pathology, Wound Healing/*physiology, Yu Bing
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.
Tags: *gp91(phox), *Microglia, *MPTP, *Na(v)1.6, *Neuroinflammation, *Parkinson's disease, *TNF-alpha, *Voltage-gated sodium channels, *Zonisamide, 2018, Aged, Animals, Antiparkinson Agents/*pharmacology, Experimental neurology, Female, Gearing Marla, Hossain Muhammad M, Humans, Inbred C57BL, Inflammation/metabolism, Male, Mice, Microglia/drug effects/*metabolism, NAV1.6 Voltage-Gated Sodium Channel/*biosynthesis, Neuroprotective Agents/pharmacology, Parkinsonian Disorders/*metabolism/pathology, Reuhl Kenneth, Richardson Jason R, Weig Blair, Wu Long-Jun, Zonisamide/*pharmacology
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
Tags: *Signal Transduction, 2018, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*antagonists & inhibitors/pharmacology, Department of Integrative Medical Sciences, Disease Models, Ferrell Jessica M, G-Protein-Coupled/*metabolism, Gastrointestinal Microbiome/*drug effects, Glucagon-Like Peptide 1/metabolism, Gonzalez Frank J, GTP-Binding Proteins/*metabolism, Hepatology (Baltimore, Md.), Inbred C57BL, Krausz Kristopher W, Lipid Metabolism, Male, Mice, NEOMED College of Medicine, Nichols Robert G, Pathak Preeti, Patterson Andrew D, Random Allocation, Receptors, Sensitivity and Specificity, Xie Cen
Modulatory effects of testosterone on
Tags: *MPTP Poisoning, 1-Methyl-4-phenyl-1, 1994, 2, 3, 6-tetrahydropyridine/antagonists & inhibitors, Animals, Corpus Striatum/drug effects/*metabolism, Dluzen D, Dopamine/*metabolism, Drug Implants, Inbred C57BL, Inbred Strains, Jain R, Journal of neurochemistry, Levodopa/pharmacology, Liu B, Male, Mice, Neurotoxins/antagonists & inhibitors/*toxicity, Orchiectomy, Parkinson Disease, Reference Values, Secondary/chemically induced/*physiopathology, Species Specificity, Testosterone/administration & dosage/*pharmacology
The effects of intranasal infusion of
Tags: 1-Methyl-4-phenyl-1, 1996, 2, 3, 6-tetrahydropyridine/administration & dosage/*pharmacology, Administration, Animals, Brain research, Catecholamines/*metabolism, Corpus Striatum/drug effects/*metabolism, Department of Internal Medicine, Dluzen D E, Dopamine Agents/administration & dosage/*pharmacology, Dopamine/metabolism, Inbred C57BL, Injections, Intranasal, Intraperitoneal, Kefalas G, Male, Mice, NEOMED College of Medicine, Norepinephrine/metabolism, Olfactory Bulb/drug effects/*metabolism
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Brain-targeted delivery of paclitaxel using glutathione-coated nanoparticles for brain cancers.
Tags: *Drug Delivery Systems, 2011, Adenosine Triphosphatases/metabolism, Animals, Antineoplastic Agents, ATP Binding Cassette Transporter, Blood-Brain Barrier/metabolism, Brain Neoplasms/drug therapy, Bui Thong, Cell Death/drug effects, Cell Line, Coumarins/administration & dosage/pharmacokinetics, Delayed-Action Preparations, Geldenhuys Werner, Glioma/drug therapy/pathology, Glutathione/*chemistry, Harrison Kimberly, Humans, Inbred C57BL, Journal of drug targeting, Male, Mbimba Thomas, Member 1/metabolism, Mice, Microtubules/metabolism, Nanoparticles, Paclitaxel/administration & dosage/*pharmacokinetics/pharmacology, Particle Size, Permeability, Phytogenic/administration & dosage/*pharmacokinetics/pharmacology, Rats, Subfamily B, Sutariya Vijaykumar, Thiazoles/administration & dosage/pharmacokinetics, Tubulin/metabolism, Tumor
TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.
Tags: 2016, Adapala Ravi K, Animals, Cappelli Holly C, Carcinoma, Cell Movement/physiology, Department of Integrative Medical Sciences, endothelial cell, Endothelial Cells/metabolism/pathology, Inbred C57BL, Kanugula Anantha K, Knockout, Lewis Lung/metabolism/*pathology, Mechanotransduction, Mice, NEOMED College of Medicine, Neovascularization, Oncotarget, Paruchuri Sailaja, Pathologic/*metabolism/pathology, rho-Associated Kinases/*metabolism, Rho/Rho kinase, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/*metabolism, TRPV4, tumor angiogenesis
TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.
Tags: 13-dienoic Acid/*antagonists & inhibitors/pharmacology, 15-Hydroxy-11 alpha, 2017, 9 alpha-(epoxymethano)prosta-5, Andrei Spencer R, Animals, Bratz Ian N, Cells, Coronary Vessels/*drug effects/metabolism, Cultured, Damron Derek S, Endothelial Cells/drug effects/metabolism, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism, Male, Mice, Microvessels/drug effects/metabolism, Nitric Oxide Synthase Type III/metabolism, PloS one, Propofol/*pharmacology, Showalter Loral E, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/*metabolism, Vasoconstrictor Agents/antagonists & inhibitors/pharmacology, Vasodilation/drug effects/physiology, Vasodilator Agents/*pharmacology
Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
Tags: 2016, Animal, Animals, Aorta, Benzofurans/chemistry/*pharmacology, Blood Pressure/drug effects, Brain/blood, Cardiac/cytology/drug effects/metabolism, Cell Line, Chen Renshan, Chinese Herbal/chemistry/pharmacology, Disease Models, Drugs, GATA4 Transcription Factor/metabolism, Gu Weiwang, Heart Failure/metabolism/*pathology, Heart Ventricles/diagnostic imaging, Inbred C57BL, Male, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/metabolism/pathology, Myocytes, Natriuretic Peptide, Phosphorylation/drug effects, PloS one, Proto-Oncogene Proteins c-akt/metabolism, Qi Jianyong, Rats, Signal Transduction/*drug effects, Tan Yafang, Thoracic/surgery, Wu Jiashin, Yu Juan, Zhang Minzhou
Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels.
Tags: 2015, Animals, Arterial Pressure/drug effects, Bratz Ian N, Damron Derek S, Drug Evaluation, Female, Inbred C57BL, Knockout, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*physiology, Male, Mice, Nitric Oxide/*physiology, PloS one, Preclinical, Propofol/*pharmacology, Signal Transduction, Sinha Sayantani, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*metabolism, TRPA1 Cation Channel, TRPV Cation Channels/genetics/metabolism, Vasodilator Agents/*pharmacology
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
Tags: *Postprandial Period, 2014, Acetylation/drug effects, Animals, ATP Citrate (pro-S)-Lyase/metabolism, Blood Glucose/*metabolism, Carboxylic Ester Hydrolases/*metabolism, Cheng Gang, Chromatin/metabolism, Department of Integrative Medical Sciences, Enzymologic/drug effects, Gene Expression Regulation, Glucose/*pharmacology, Histones/metabolism, Homeostasis, Inbred C57BL, Li Yuanyuan, Liver/*enzymology, Male, Mice, NEOMED College of Medicine, Nutritional Status, PloS one, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.
Tags: 2017, Abdala Carolina, Animals, Coate Thomas Matthew, Cruz Charlene, Female, Friedman Rick A, Ge Marshall X, Gundimeda Usha, Inbred C57BL, Kelley Matthew William, Knockout, Lael Cantu Homero, Lavinsky Joel, Male, Mice, Michelle Baum Leah, Myint Anthony, Neurogenesis, Neurons/cytology, Neuropilin-1/genetics/*metabolism, Nikolakopoulou Angeliki Maria, Ohyama Takahiro, PLoS genetics, Salehi Pezhman, Semaphorin-3A/genetics/*metabolism, Signal Transduction, Spiral Ganglion/cytology/*embryology, Tao Litao, Wang Juemei
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Askew Michael J, Biomechanical Phenomena, Body Weight/drug effects, Bone and Bones/drug effects, Bone/prevention & control, Collagen Type I, Collagen/genetics, Densitometry, Department of Family & Community Medicine, Disease Models, Femur/drug effects/pathology, Fractures, Growth Hormone/*therapeutic use, Heterozygote, Humans, Inbred C57BL, Jarjoura David, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, King Donna, Lumbar Vertebrae/drug effects, McEwen Heather A, Mice, Mutation, NEOMED College of Medicine, Osteoblasts/*drug effects/metabolism, Osteogenesis Imperfecta/*drug therapy, Phenotype, Time Factors, Transgenic
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Tags: *estrogen, *estrogen receptor alpha, *lipid and lipoprotein metabolism, *small heterodimer partner, *triglycerides, *very low density lipoprotein, 2016, Animals, Cholesterol Ester Transfer Proteins/*physiology, Department of Integrative Medical Sciences, Estrogen Receptor alpha/metabolism, Estrogens/physiology, Female, Inbred C57BL, Journal of lipid research, Le Thao D, Lee Yoon-Kwang, Lipid Metabolism, Liver/*metabolism, Metabolic Networks and Pathways, Mice, NEOMED College of Medicine, Oxidation-Reduction, Palmisano Brian T, Stafford John M, Transgenic, Triglycerides/biosynthesis/*blood, Zhu Lin
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Tags: *Alzheimers disease, *Immunity, *Inflammation, *Tauopathy, *TREM2, 2017, Allan Kevin, Animal, Animals, Bemiller Shane M, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Formica Shane V, Humans, Immunologic/*deficiency, Inbred C57BL, Kokiko-Cochran Olga N, Lamb Bruce T, Landreth Gary E, Lasagna-Reeves Cristian A, McCray Tyler J, Membrane Glycoproteins/*deficiency, Mice, Microglia/metabolism, Molecular neurodegeneration, NEOMED College of Pharmacy, Protein Kinases/*metabolism, Ransohoff Richard M, Receptors, Signal Transduction/physiology, tau Proteins/*metabolism, Tauopathies/metabolism/*pathology, Transgenic, Wilson Gina, Xu Guixiang
Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling.
Tags: 2017, Adenosine Triphosphate – Metabolism, Adenosine Triphosphate/*metabolism, Ammi Azzdine Y, Animal Studies, Animals, Belcik J Todd, Chilian William M, Chon Chae Ryung, Circulation, contrast echocardiography, Davidson Brian P, Department of Integrative Medical Sciences, Equipment and Supplies, Field Joshua, Harmann Leanne, Hemodynamics, Humans, Inbred C57BL, Liang Sherry, Linden Joel, Lindner Jonathan R, Male, Mice, Microbubbles, Microcirculation, Muscle, NEOMED College of Medicine, Neurotransmitter Agents – Metabolism, Perfusion, Purinergic Agents/*metabolism, Qi Yue, Signal Transduction, Skeletal – Blood Supply, Skeletal/*blood supply, Ultrasonography – Methods, Ultrasonography/*methods, Wu Melinda D, Xie Aris, Yadava Mrinal
Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction.
Tags: 2012, Agarwal Udit, Animals, Apoptosis/physiology, Cardiac/cytology/physiology, Cell Movement/physiology, Chemokine CXCL12/*metabolism, Circulation, Coronary Circulation/physiology, CXCR4/*genetics/metabolism, Department of Integrative Medical Sciences, Dong Feng, Finan Amanda, Gene Expression/physiology, Green Fluorescent Proteins/genetics, Harvey James, Inbred C57BL, Knockout, Mesenchymal Stem Cell Transplantation/*methods, Mesenchymal Stem Cells/*metabolism, Mice, Myocardial Infarction/genetics/pathology/*therapy, Myocardium/cytology, Myocytes, NEOMED College of Medicine, Paracrine Communication/physiology, Penn Marc S, Receptors, Ventricular Remodeling/physiology, Weber Kristal
Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation.
Tags: 129 Strain, 2015, Animals, Bardakjian Raffi, Bratz Ian, Cardiac function, Chilian William M, Circulation research, contrast echocardiography, Coronary Circulation/*physiology, Coronary Vessels/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Enrick Molly, Fu Frances Kwan, Graham Jacqueline, Hakobyan Tatevik, Hou Huagang, Hydrogen peroxide, Inbred C57BL, ion channel, Janota Danielle, Khan Nadeem, Kmetz John, Knockout, Kolz Christopher, Kuppusamy Periannan, Kv1.5 Potassium Channel/*physiology, Lindner Jonathan R, Logan Suzanna, Luli Jordan, Mice, Muscle, Nagane Masaki, NEOMED College of Medicine, NEOMED College of Pharmacy, Ohanyan Vahagn, Oyewumi Moses O, Smooth, Transgenic, Transgenic mice, Vascular/*metabolism, vasodilation, Vasodilation/*physiology, voltage-gated potassium channels, Yin Liya
Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis.
Tags: 2011, Adenoviridae/genetics, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Cells, Cholesterol, Cholesterol/*metabolism, Cultured, Department of Integrative Medical Sciences, Edwards Peter A, Fatty Liver/metabolism/physiopathology, Ge Xuemei, HDL/metabolism, Hepatocyte Nuclear Factor 4/drug effects/genetics/*physiology, Hepatocytes/cytology/*metabolism, Homeostasis/genetics/*physiology, Inbred C57BL, Lipid Metabolism/genetics/physiology, Ma Huiyan, Mice, Models, NEOMED College of Medicine, RNA, Small Interfering/genetics/pharmacology, Triglycerides/*metabolism, VLDL/metabolism, Yin Liya, Zhang Yanqiao
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X
Endothelin-mediated in vivo pressor responses following TRPV1 activation.
Tags: *Blood Pressure/drug effects, *Vasoconstriction/drug effects, 2011, Adrenergic alpha-Agonists/administration & dosage, American journal of physiology. Heart and circulatory physiology, Analysis of Variance, Animal, Animals, Azepines/administration & dosage, Biphenyl Compounds/administration & dosage, Bratz Ian N, Capsaicin/administration & dosage, Cells, Cultured, Damron Derek S, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/genetics/*metabolism/physiopathology, Dipeptides/administration & dosage, Disease Models, Dose-Response Relationship, Drug, Endothelial Cells/metabolism, Endothelin A Receptor Antagonists, Endothelin A/metabolism, Endothelin B Receptor Antagonists, Endothelin B/metabolism, Endothelin-1/*metabolism, Enzyme-Linked Immunosorbent Assay, Femoral Artery/drug effects/*metabolism/physiopathology, Guarini Giacinta, Haney Rebecca M, Inbred C57BL, Indoles/administration & dosage, Infusions, Intravenous, Knockout, Male, Meszaros J Gary, Mice, NEOMED College of Medicine, Ohanyan Vahagn A, Phenylephrine/administration & dosage, Raman Priya, Receptor, Talasila Phani K, Thodeti Charles K, TRPV Cation Channels/agonists/deficiency/genetics/*metabolism, Type 2/genetics/*metabolism/physiopathology, Vasoconstrictor Agents/administration & dosage
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.
Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects
Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice.
Tags: *acetaldehyde dehydrogenase, *alcoholic fatty liver disease, *Inflammation, *small heterodimer partner, 2016, Acetates/blood, Alcoholic/genetics/*metabolism, Aldehyde Dehydrogenase, American journal of physiology. Gastrointestinal and liver physiology, Animals, Cytoplasmic and Nuclear/deficiency/*genetics/metabolism, Department of Integrative Medical Sciences, Ethanol/blood/*metabolism/toxicity, Inbred C57BL, Lee Mikang, Lee Yoon-Kwang, Lipid Peroxidation, Liver Diseases, Liver/drug effects/metabolism, Male, Mice, Mifflin Ryan, Mitochondrial/genetics/metabolism, NEOMED College of Medicine, Park Jung Eun, PPAR gamma/genetics/metabolism, Receptors
Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
Tags: 2012, Adapala Ravi K, American journal of physiology. Cell physiology, Animals, Cell Movement/physiology, Cells, Chavez Ronaldo J, Cuadra Rene H, Cultured, Department of Integrative Medical Sciences, Ganguly Rituparna, Gene Expression Regulation/physiology, Haney Rebecca M, Humans, Inbred C57BL, Janus Kinase 2/*biosynthesis, Knockout, Leptin/*physiology, Male, MAP Kinase Signaling System/*physiology, Mice, Muscle, Myocytes, NEOMED College of Medicine, Raman Priya, Smooth, Smooth Muscle/enzymology/metabolism, Thodeti Charles K, Thrombospondin 1/*biosynthesis, Up-Regulation/*physiology, Vascular/enzymology/*metabolism
MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the
Tags: *CYTOKINES, *ETHANOL, *FATTY LIVER, *Inflammation, *LEUKOCYTES, 2017, Adult, Alanine Transaminase/blood, Alcoholic/genetics/*metabolism/pathology, Alcoholism/*blood/complications, Animals, Aspartate Aminotransferases/blood, Bilirubin/blood, Binge Drinking/*blood/complications, Cai Yan, Cao Haixia, Case-Control Studies, Central Nervous System Depressants/administration & dosage, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Down-Regulation, Ethanol/administration & dosage, Female, Feng Dechun, Gao Bin, Gao Yanhang, Gao Yueqiu, Gut, He Yong, Humans, Inbred C57BL, Interleukin-6/genetics/metabolism, Li Man, Liangpunsakul Suthat, Liver Diseases, Male, Mice, MicroRNAs/*blood/*genetics, Middle Aged, NADPH Oxidases/genetics/metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Neutrophils/*metabolism, Ramirez Teresa, Reactive Oxygen Species/metabolism, Ross Ruth A, Up-Regulation, Xu Ming-Jiang, Young Adult, Zhang Ping, Zhou Zhou
Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.
Tags: 2013, Alcohol-Induced Injury, Alcoholic Liver Disease, Alcoholic/genetics/*metabolism/prevention & control, Animals, Cannabinoid, CB1/*physiology, Chiang John Y L, Choi Hueng-Sik, Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP2E1/genetics/*metabolism, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology/therapeutic use, Enzymologic/drug effects/physiology, Estrogen/deficiency/genetics/*physiology, Ethanol/pharmacology, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulation, Genetic/physiology, Gut, Inbred C57BL, Jang Hyun-Hee, Jeong Won-Il, Kim Don-Kyu, Kim Jung Ran, Kim Yong-Hoon, Knockout, Koh Minseob, Koo Seung-Hoi, Lee Chul-Ho, Liver, Liver Diseases, Liver Metabolism, Liver/metabolism, Male, Mice, NEOMED College of Medicine, Oxidation-Reduction, Oxidative Stress/physiology, Park Jinyoung, Park Seung Bum, Park Tae-Sik, Receptor, Receptors, Signal Transduction/drug effects/physiology, Tamoxifen/analogs & derivatives/pharmacology/therapeutic use, Transcription, Yun Chul-Ho
Effects of growth hormone transgene expression on vertebrae in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Beamer Wesley G, Biomechanical Phenomena, Bone Density, Chase Jeff, Department of Family & Community Medicine, Disease Models, Female, Gene Expression, Genetic Therapy/*methods, Havey Robert M, Heterozygote, Human Growth Hormone/*genetics, Humans, Inbred C57BL, King Donna, Male, McEwen Heather A, Mice, NEOMED College of Medicine, Osteogenesis Imperfecta/pathology/physiopathology/*therapy, Patwardhan Avinash G, Sartori Mark, Spine, Spine/pathology/*physiology, Tail, Transgenic, Voronov Leonard
Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Tags: *Airway Remodeling, *fibronectin, *myofibroblasts, *PAI-1, *PI3K, *TGF-beta1, 2017, Adult, Al-Azzam Nosayba, Animals, Asthma/etiology/genetics/*metabolism/pathology, Cells, Cultured, Department of Integrative Medical Sciences, Dermatophagoides farinae/immunology, Duah Ernest, Extracellular Matrix/*metabolism/pathology, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Fibroblasts/metabolism, Fibronectins/*metabolism, Gombedza Farai, Hexter Madison, Humans, Inbred C57BL, Kondeti Vinay, Koppes Stephanie, Male, Mice, NEOMED College of Medicine, Paruchuri Sailaja, Patil Prachi, Phillips Daniel, Phosphatidylinositol 3-Kinases/metabolism, Plasminogen Activator Inhibitor 1/metabolism, Thodeti Charles K, Transforming Growth Factor beta/metabolism, TRPV Cation Channels/genetics/*metabolism
Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.
Tags: *deltamethrin, *intracellular sodium., *Microglia, *neurodegeneration, *Neuroinflammation, *permethrin, *pyrethroids, *tetrodotoxin, *tumor necrosis factor, *Voltage-gated sodium channels, 2017, Animals, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Hossain Muhammad M, Inbred C57BL, Insecticides/*toxicity, Ion Channel Gating/*drug effects, Liu Jason, Mice, Microglia/*drug effects/metabolism, NEOMED College of Pharmacy, Pyrethrins/*toxicity, Richardson Jason R, Sodium Channels/*drug effects, Toxicological sciences : an official journal of the Society of Toxicology, Transformed, Tumor Necrosis Factor-alpha/metabolism
Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease.
Tags: 2016, Alzheimer Disease/etiology/*metabolism/pathology, Alzheimer's disease, Amyloid beta-Peptides/*metabolism, Animal, Animal/physiology, Animals, Behavior, Bemiller Shane M, Bhaskar Kiran, Blotting, Brain Injuries, Brain/*metabolism/pathology, Crish Samuel, Department of Pharmaceutical Sciences, Disease Models, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Inbred C57BL, Inflammation/*metabolism/pathology, Journal of neurotrauma, Kokiko-Cochran Olga N, Lamb Bruce T, Lee Sungho, Lee Yu-Shang, macrophage, Mice, NEOMED College of Pharmacy, Neuroinflammation, Ransohoff Lena, Ransohoff Richard M, Saber Maha, Sikora Matt, Teknipp Ryan, Transgenic, Traumatic brain injury, Traumatic/complications/*metabolism/*pathology, Veenstra Mike, Western, Wilson Gina, Xu Guixiang
TRPA1 ion channel stimulation enhances cardiomyocyte contractile function via a CaMKII-dependent pathway.
Tags: [Ca2+]i, *Myocardial Contraction, 2017, Andrei Spencer R, Animals, Bratz Ian N, Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism, CaMKII, Cardiac/*metabolism, cardiomyocytes, Channels (Austin, Tex.), contractility, Damron Derek S, Dey Souvik, Ghosh Monica, Inbred C57BL, Knockout, Mice, Myocytes, Sinharoy Pritam, TRPA1, TRPA1 Cation Channel/deficiency/*metabolism
TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: Co-localization at z-discs, costameres and intercalated discs.
Tags: 2016, Andrei Spencer R, Animals, Bratz Ian N, Ca2+, Calcium/physiology, Cardiac/*physiology, cardiomyocytes, Channels (Austin, Tex.), Damron Derek S, Inbred C57BL, Male, Mice, Myocytes, Sinharoy Pritam, Transient Receptor Potential Channels/genetics/*physiology, TRPA1, TRPA1 Cation Channel, TRPV Cation Channels/genetics/*physiology, TRPV1, Z-disc
Brain reactive antibodies and the blood-brain barrier: observations in aging rodents and the effects of peripheral kainic acid.
Tags: 1987, Aging/*immunology/physiology, Albrecht J W, Animals, Autoantibodies/blood/*physiology, Blood-Brain Barrier/*drug effects, Boja J W, Brain/*immunology/physiology, Experimental aging research, Hippocampus/immunology/physiology, Hutton J T, Inbred C57BL, Inbred Strains, Kainic Acid/*pharmacology, Kulmala H K, Male, Mice, Rats
Analysis of osteopontin in mouse growth plate cartilage by application of laser capture microdissection and RT-PCR.
Tags: *Reverse Transcriptase Polymerase Chain Reaction, 2003, Animals, Articular/chemistry/cytology, Cartilage, Chondrocytes/chemistry, Connective tissue research, Gene Expression, Growth Plate/*chemistry/cytology, Hillyer Jennifer, Inbred C57BL, Jacquet Robin, Landis William J, Laser Therapy, Messenger/metabolism, Mice, Microdissection/*methods, Newborn, Non-programmatic, Osteopontin, RNA, Sialoglycoproteins/*analysis/genetics, Tibia, Zhang Jean