Browse Items (14 total)
- Tags: Up-Regulation
Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy
Tags: 2013, activated protein-kinase, alzheimers-disease brain, amyotrophic-lateral-sclerosis, Axonopathy, Calkins D J, Crish S D, Dapper J D, Death, Department of Pharmaceutical Sciences, experimental glaucoma, ganglion-cell neurons, Glaucoma, Heat shock protein, Journal Article or Conference Abstract Publication, Mouse model, NEOMED College of Pharmacy, Neurobiology of disease, Neurodegeneration, Neurosciences & Neurology, Ocular Hypertension, p38 MAPK, Pang I H, rat retina, Retinal ganglion cell, Up-Regulation
Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice
Tags: 2006, active sodium-transport, alveolar fluid clearance, alveolar liquid clearance, American Journal of Physiology-Lung Cellular and Molecular Physiology, barrier function, beta-adrenoceptor inhibition, dependent, Escherichia coli, Folkesson H G, hemorrhagic-shock, ion-transport, Journal Article, Matthay M A, Physiology, protein-kinase, pulmonary edema, Respiratory System, respiratory-distress syndrome, Robriquet L, septic, Shock, Sodium channel, Su X, Up-Regulation
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Tags: *Apoptosis, *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, 2018, 70-kDa/metabolism, 90-kDa/metabolism, Ahmad Imran, Carboxylic Ester Hydrolases/metabolism, Caspases/metabolism, Cells, Chondrocytes/*physiology, Cultured, ets-Domain Protein Elk-1/metabolism, Free radical biology & medicine, Haqqi Tariq M, Humans, Interleukin-1beta/immunology, Khan Nazir M, MAP Kinase Signaling System, NF-E2-Related Factor 2/genetics/*metabolism, Osteoarthritis/*metabolism, Oxidative Stress, Ribosomal Protein S6 Kinases, Up-Regulation
Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.
Tags: 2014, Adult, Aged, beta Catenin/analysis/*biosynthesis, beta-catenin, Biomarkers, Cyclin D1/analysis/*biosynthesis, cyclinD1, Cystadenocarcinoma, Dai Yingqing, Female, Humans, Immunohistochemistry, International journal of clinical and experimental pathology, Kaplan-Meier Estimate, Liu Qi, Makki Mohammad Shahidul, Middle Aged, Neoplasm Staging, Ovarian Neoplasms/*metabolism/mortality/pathology, ovarian serous carcinoma, Prognosis, Serous/*metabolism/mortality/pathology, Shi Qunli, Tumor/*analysis, Up-Regulation, Wang Hai, Wang Haiyan, Wang Jiandong, Wen Juanjuan, Young Adult, Zhou Xiaojun
Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Tags: 2009, Adult, Antigens/biosynthesis, Articular/metabolism, Baraga Anthony, Biomarkers/metabolism, Bone Neoplasms/metabolism, Cartilage, Chondrosarcoma/metabolism, Collagen Type VI/*biosynthesis, Department of Anatomy & Neurobiology, DNA-Binding Proteins/*biosynthesis, Doane Kathleen J, Down-Regulation, Endoplasmic Reticulum/*metabolism, Gradisar Ian, Heat-Shock Proteins/*biosynthesis, Horton Walter E Jr, Humans, Knee/*metabolism/physiopathology, McBurney Denise L, Middle Aged, NEOMED College of Medicine, Nugent Ashleigh E, Osteoarthritis, Osteosarcoma/metabolism, Proteoglycans/biosynthesis, Speicher Danielle M, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Transcription Factors/*biosynthesis, Up-Regulation
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
Tags: 2008, Animal, Animals, Brain Injuries/blood/epidemiology/genetics/*physiopathology, Cerebral Cortex/physiopathology, Chemokine CCL2/genetics/physiology, Chemokines/*genetics, Cytokines/*antagonists & inhibitors, Disease Models, Hippocampus/physiopathology, Inflammation/genetics/*physiopathology, Interleukin-1beta/genetics/physiology, Interleukin-6/genetics/physiology, Journal of neuroinflammation, Lloyd Eric, Male, Mice, Somera-Molina Kathleen, Tumor Necrosis Factor-alpha/genetics/physiology, United States/epidemiology, Up-Regulation, Van Eldik Linda J, Wainwright Mark S, Watterson D Martin
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
Tags: 2005, American journal of physiology. Gastrointestinal and liver physiology, Bile Acids and Salts/pharmacology, Chiang John Y L, Cholestasis/*physiopathology, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/pharmacology, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/pharmacology, Enzyme Inhibitors/*pharmacology, Genetic, Glucocorticoid, Hepatoblastoma/pathology, Hepatocyte Nuclear Factor 4, Humans, Li Tiangang, Liver Neoplasms/pathology, Messenger/analysis/biosynthesis, NEOMED College of Medicine, Phosphoproteins/pharmacology, Pregnane X Receptor, Receptors, Rifampin/*pharmacology, RNA, Steroid/*physiology, Transcription, Transcription Factors/pharmacology, Tumor Cells, Up-Regulation
MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the
Tags: *CYTOKINES, *ETHANOL, *FATTY LIVER, *Inflammation, *LEUKOCYTES, 2017, Adult, Alanine Transaminase/blood, Alcoholic/genetics/*metabolism/pathology, Alcoholism/*blood/complications, Animals, Aspartate Aminotransferases/blood, Bilirubin/blood, Binge Drinking/*blood/complications, Cai Yan, Cao Haixia, Case-Control Studies, Central Nervous System Depressants/administration & dosage, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Down-Regulation, Ethanol/administration & dosage, Female, Feng Dechun, Gao Bin, Gao Yanhang, Gao Yueqiu, Gut, He Yong, Humans, Inbred C57BL, Interleukin-6/genetics/metabolism, Li Man, Liangpunsakul Suthat, Liver Diseases, Male, Mice, MicroRNAs/*blood/*genetics, Middle Aged, NADPH Oxidases/genetics/metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Neutrophils/*metabolism, Ramirez Teresa, Reactive Oxygen Species/metabolism, Ross Ruth A, Up-Regulation, Xu Ming-Jiang, Young Adult, Zhang Ping, Zhou Zhou
TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.
Tags: 2015, Adapala Ravi K, Animals, Antineoplastic Agents/pharmacology, Cappelli Holly C, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Dudley Andrew C, Endothelial Cells/drug effects/metabolism, Kondeti Vinay, Leucine/analogs & derivatives/pharmacology, MAP Kinase Signaling System, Meszaros J Gary, Mice, NEOMED College of Medicine, Neoplasms/drug therapy/*metabolism/pathology, Neovascularization, Paruchuri Sailaja, Pathologic/drug therapy, Scientific reports, Sulfonamides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/drug effects/genetics/*metabolism, Up-Regulation
miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes.
Tags: *Apoptosis, 2015, 3' Untranslated Regions, Aged, Chondrocytes/*metabolism/pathology, Department of Anatomy & Neurobiology, Down-Regulation, Experimental & molecular medicine, Female, Gene Expression Regulation, Haqqi Tariq M, Humans, Interleukin-6/*genetics, Makki Mohammad Shahidul, Male, Messenger/genetics, MicroRNAs/*genetics, Middle Aged, NEOMED College of Medicine, Osteoarthritis/*genetics/pathology, Ribonucleases/*genetics, RNA, Transcription Factors/*genetics, Up-Regulation
Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.
Tags: 2003, Afferent/metabolism, Amann R, Animals, Cervix Uteri/cytology/*metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Estradiol/*analogs & derivatives/pharmacology, Estrogen/antagonists & inhibitors, Estrogens/*pharmacology, Female, Fulvestrant, Ganglia, Immunohistochemistry, In Situ Hybridization, Messenger/genetics/metabolism, Mowa C N, NEOMED College of Medicine, Neurons, Papka R, Peptides, Postpartum Period, Pregnancy/*metabolism, Radioimmunoassay, Rats, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Spinal Cord/cytology/*metabolism, Spinal/cytology/*metabolism, Sprague-Dawley, Storey-Workley M, Substance P/*biosynthesis/genetics/metabolism, Up-Regulation, Usip S
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Tags: 2011, Animals, Anthocyanins/*therapeutic use, Anticarcinogenic Agents/therapeutic use, Apoptosis/drug effects, bcl-2-Associated X Protein/metabolism, Bishayee Anupam, Cell Proliferation/drug effects, Chemoprevention, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine, Down-Regulation, Experimental/metabolism/pathology, Folkesson Hans G, Haznagy-Radnai Erzsebet, Hohmann Judit, Liver Neoplasms, Liver Neoplasms/chemically induced/*prevention & control, Liver/pathology, Male, Mbimba Thomas, NEOMED College of Pharmacy, Phenobarbital, Plant Extracts/*therapeutic use, Proliferating Cell Nuclear Antigen/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, Rats, Ribes/chemistry, Sipos Peter, Sprague-Dawley, The Journal of nutritional biochemistry, Thoppil Roslin J, Up-Regulation
Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.
Tags: 2000, Alitretinoin, Antineoplastic Agents/*pharmacology, Biochemical and biophysical research communications, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Hardwick J P, Humans, Hydroxylation, Leukotriene B4/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Tretinoin/*pharmacology, Tumor Cells, Up-Regulation, Zhang X