Browse Items (14 total)
- Tags: Signal Transduction/drug effects
Tags: *Neuroinflammation, *Parkinson's disease, 1-Methyl-4-phenyl-1, 2, 2018, 3, 6-tetrahydropyridine/pharmacology, Analysis of Variance, Animals, Anti-Inflammatory Agents/*therapeutic use, Astrocyte, Astrocytes/*drug effects, Boyle Alexa M, Budge Kevin M, Case-Control Studies, CD44, Cells, Chemical, Cultured, Cytokines/genetics/metabolism, Databases, Female, Glial Fibrillary Acidic Protein/metabolism, GPNMB, Humans, Hyaluronan Receptors/*metabolism, Inflammation/*drug therapy/etiology, Journal of neuroinflammation, Male, Membrane Glycoproteins/*therapeutic use, Messenger/metabolism, Mice, Neal Matthew L, Neurotoxins/toxicity, Nitric Oxide/metabolism, Parkinson Disease/complications/*pathology, Reactive Oxygen Species/metabolism, Richardson Jason R, RNA, Safadi Fayez F, Signal Transduction/drug effects
Tags: 2012, Cytoplasmic and Nuclear/antagonists & inhibitors/*metabolism, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, DNA/metabolism, Drug Evaluation, Future medicinal chemistry, Humans, Ligands, MicroRNAs/metabolism, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Peptides/chemistry/pharmacology, Preclinical, Protein Binding, Receptors, Sadana Prabodh, Signal Transduction/drug effects, Small Molecule Libraries/chemistry/pharmacology
Tags: 2013, Amyloid beta-Peptides/antagonists & inhibitors, Animals, Calcium Channel Blockers/chemistry/pharmacology, Cholinesterase Inhibitors/chemistry/pharmacology, Current medicinal chemistry, Drug Discovery/*methods, Geldenhuys W J, Humans, Molecular Targeted Therapy/methods, Monoamine Oxidase Inhibitors/chemistry/pharmacology, N-Methyl-D-Aspartate/antagonists & inhibitors, Neurodegenerative Diseases/*drug therapy/metabolism, Receptors, Signal Transduction/drug effects, Van der Schyf C J
Postreceptor defects in alveolar epithelial beta-adrenergic signaling after prolonged isoproterenol infusion.
Tags: 2003, 8-Bromo Cyclic Adenosine Monophosphate/pharmacology, Adenylyl Cyclases/metabolism, Adrenergic, Adrenergic beta-Agonists/*pharmacology, American journal of physiology. Lung cellular and molecular physiology, Animals, beta/*metabolism, Colforsin/pharmacology, Cyclic AMP-Dependent Protein Kinase Type II, Cyclic AMP-Dependent Protein Kinases/metabolism, Cyclic AMP/metabolism, Extravascular Lung Water/metabolism, Folkesson Hans G, Hodnichak Cheryl M, Isoproterenol/*pharmacology, Male, Maron Michael B, Mavrich Kate E, Morgan Eric E, Pulmonary Alveoli/*drug effects/*metabolism, Pulmonary Edema/metabolism, Rats, Receptors, Respiratory Mucosa/drug effects/metabolism, Signal Transduction/drug effects, Sprague-Dawley, Stader Sonya M
Tags: 2005, 70-kDa/metabolism, American journal of physiology. Heart and circulatory physiology, Angiotensin II/pharmacology, Animals, Antioxidants/*pharmacology, Bomser Joshua A, Cell Differentiation/drug effects, Cell Division/drug effects, Cells, Cultured, Department of Integrative Medical Sciences, Drug Interactions, Epidermal Growth Factor/pharmacology, Fibroblasts/*cytology/*drug effects, Male, Meszaros J Gary, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/*cytology, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins/metabolism, Rats, Resveratrol, Ribosomal Protein S6 Kinases, Signal Transduction/drug effects, Sprague-Dawley, Stilbenes/*pharmacology, Vasoconstrictor Agents/pharmacology, Zhang Xiaojin
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
Tags: 2005, Blotting, Calcium Channels/drug effects/metabolism, Department of Integrative Medical Sciences, DNA/biosynthesis/genetics, Dose-Response Relationship, Drug, Fluorescent Antibody Technique, Genes, Glutamic Acid/*metabolism, Humans, Kammermeier Paul J, Membrane Potentials/drug effects, Metabotropic Glutamate/genetics/*metabolism, myc/genetics, NEOMED College of Medicine, Patch-Clamp Techniques, Plasmids/genetics, Receptors, Signal Transduction/drug effects, Superior Cervical Ganglion/cytology/drug effects/metabolism, Sympathetic Nervous System/cytology/drug effects/metabolism, The Journal of pharmacology and experimental therapeutics, Western, Yun June
Tags: 2017, Angiogenesis Inducing Agents/*metabolism, Animals, Cell Movement/drug effects, Cell Proliferation/drug effects, Cells, Chick Embryo, Cultured, Department of Integrative Medical Sciences, Endothelium, Female, Gene Expression Regulation/drug effects, Habib N, Humans, Inbred C57BL, Krukovets I, Male, Mice, Muppala S, Muscle, NEOMED College of Medicine, Neovascularization, Oncogene, Pathologic/drug therapy/metabolism/*pathology, Plow E, Raman P, Signal Transduction/drug effects, Smooth, Stenina-Adognravi O, Thrombospondins/*physiology, Transforming Growth Factor beta/*pharmacology, Vascular/drug effects/metabolism/*pathology, Verbovetsky D, Xiao R, Yendamuri R
Tags: 2015, Animals, Antineoplastic Agents/*adverse effects/pharmacology, Antitumor, Auditory, Bao Jianxin, Canertinib, Carcinoma, Chen Xiaojie, DeCook Rhonda, Department of Anatomy & Neurobiology, Ding Dalian, Drug Screening Assays, Ear, Electrophysiology, ERBB, ErbB Receptors/*antagonists & inhibitors, Female, Hair Cells, Hearing Loss/*chemically induced, Hearing research, Hearing/*drug effects, Inbred C57BL, Inbred CBA, Kobel Megan, Kopecky Benjamin J, Li Hui, Lung Neoplasms/drug therapy, Male, Mice, Morpholines/*adverse effects/pharmacology, NEOMED College of Medicine, Neuregulin-1/metabolism, Non-small cell lung cancer, Non-Small-Cell Lung/drug therapy, NRG1, Ototoxicity, Ou Henry C, Outer hair cell, Outer/*drug effects, Qian Yi, Signal Transduction/drug effects, Sun Zhenyu, Tang Jian, Zebrafish
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
Tags: *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, *Wogonin, 2017, Ansari Mohammad Y, Anti-Inflammatory Agents/administration & dosage, Chondrocytes/drug effects/pathology, Department of Anatomy & Neurobiology, Devarapalli Pratap, Flavanones/*administration & dosage, Free radical biology & medicine, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Humans, Inflammation/*drug therapy/metabolism/pathology, Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism, Khan Nazir M, MAP Kinase Signaling System/drug effects, Molecular Docking Simulation, NEOMED College of Medicine, NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism, Osteoarthritis/*drug therapy/metabolism/pathology, Protein Binding, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects
Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.
Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong
Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-kappaB signaling and T-helper cell homeostasis.
Tags: 2017, Animals, Anti-Inflammatory Agents/*pharmacology/therapeutic use, Berberine/*analogs & derivatives/pharmacology/therapeutic use, Chen Yingying, Colitis, Colon/drug effects/immunology/pathology, Cytokines/immunology, Dextran Sulfate, DMB, Female, Helper-Inducer/*drug effects/immunology, Homeostasis/drug effects, Immunoglobulin G/blood, Inbred C57BL, Inflammation research : official journal of the European Histamine Research Society ... [et al.], Inflammatory Bowel Diseases/blood/chemically induced/drug therapy/*immunology, Li Rui-Yan, Mice, NF-kappa B/*antagonists & inhibitors/immunology, NF-kappaB, RAW 264.7 Cells, Reactive Oxygen Species/metabolism, Shi Mei-Jing, Signal Transduction/drug effects, Spleen/cytology, T-Lymphocytes, Th cell, Xu Xin-Xin, Yan Yan, Zhang Miao, Zhang Yu-Bin, Zhao Xiao-Tong, Zhao Ya-Xing
A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.
Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors