Browse Items · NEOMED Bibliography Database

Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.

Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells,…

Ocular Vascular-disease - In-office Primary Care Diagnosis

Tags: 1993, Delaney W V, Geriatrics, Geriatrics & Gerontology, Infection, Neovascularization, retinal artery obstruction, Secondary

Stimulation of Coronary Collateral Growth by Granulocyte Stimulating Factor Role of Reactive Oxygen Species

Objective-The purpose of this study was to determine whether G-CSF promotes coronary collateral growth (CCG) and decipher the mechanism for this stimulation. Methods and Results-In a rat model of repetitive episodic myocardial ischemia (RI, 40…

Suppression of transforming growth factor-beta effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor

Purpose: Transforming growth factor-beta (TGF-beta) activity has been implicated in subconjunctival scarring in eyes following glaucoma filtration surgery (GFS). The purpose of this study is to determine whether an inhibitor for activin receptor-like…

Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.

Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTRs). We found that CysLT2R regulates angiogenesis in isolated mouse endothelial cells (ECs) and in Matrigel implants in…

Tags: *angiogenesis, *cysteinyl leukotriene receptors, *endothelial cells, *metastasis, *tumor growth, 2019, Adapala Ravi K, Animals, Austen K Frank, Capillary Permeability/drug effects, Cyclohexanecarboxylic Acids/pharmacology, Department of Integrative Medical Sciences, Duah Ernest, Endothelial Cells/*drug effects, Experimental, Gene Knockout Techniques, Inbred C57BL, Kanaoka Yoshihide, Keshamouni Venkateshwar G, Kondeti Vinay, Leukotriene Antagonists/pharmacology, Leukotriene/drug effects/*metabolism, Lung Neoplasms/drug therapy, Male, Mice, NEOMED College of Medicine, Neoplasm Metastasis/drug therapy, Neoplasm Transplantation, Neoplasms, Neovascularization, Paruchuri Sailaja, Pathologic/*chemically induced/drug therapy, Phthalic Acids/pharmacology, Proceedings of the National Academy of Sciences of the United States of America, Receptors, Teegala Lakshminarayan Reddy, Thodeti Charles K

Effect of Precompression on the Power Doppler Assessment of Breast Lesion Vascularity.

OBJECTIVES: To evaluate the effect of precompression on power Doppler visualization of blood flow in breast masses. METHODS: This Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant study evaluated 30…

Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy.

Hepatocellular carcinoma (HCC) remains one of the most lethal cancers in the world. Since current treatment options including surgical resection and liver transplantation offer limited therapeutic benefits, there exists a need to evaluate novel…

Tags: 2012, Angiogenesis Inhibitors/*therapeutic use, Animals, Bishayee Anupam, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Hepatocellular/blood supply/pathology/*prevention & control, Humans, Liver Neoplasms/blood supply/pathology/*prevention & control, NEOMED College of Pharmacy, Neovascularization, Pathologic/*prevention & control

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.

Targeting angiogenesis is considered a promising therapy for cancer. Besides curtailing soluble factor mediated tumor angiogenesis, understanding the unexplored regulation of angiogenesis by mechanical cues may lead to the identification of novel…

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

A brief etymology of the collateral circulation.

It is well known that the protective capacity of the collateral circulation falls short in many individuals with ischemic disease of the heart, brain, and lower extremities. In the past 15 years, opportunities created by molecular and genetic tools,…

The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth.

OBJECTIVE: We hypothesize that controversial effects of angiotensin II (Ang II) are attributable to its regulation of reactive oxygen species (ROS) and

Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.

Reactive oxygen species (ROS) are implicated in coronary collateral growth (CCG). We evaluated the requirement for ROS in human coronary artery endothelial cell (HCAEC) tube formation, CCG in vivo, and signaling (p38 MAP kinase) by which ROS may…

Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism

TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.

Endothelial cell proliferation is a critical event during angiogenesis, regulated by both soluble factors and mechanical forces. Although the proliferation of tumor cells is studied extensively, little is known about the proliferation of tumor…

Thrombospondin-4 mediates TGF-beta-induced angiogenesis.

TGF-beta is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-beta signaling are process-and stage-dependent, and it is not…

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.

Tumor vessels are characterized by abnormal morphology and hyperpermeability that together cause inefficient delivery of chemotherapeutic agents. Although vascular endothelial growth factor has been established as a critical regulator of tumor…

Coronary collateral growth–back to the future.

The coronary collateral circulation is critically important as an adaptation of the heart to prevent the damage from ischemic insults. In their native state, collaterals in the heart would be classified as part of the microcirculation, existing as…

Tags: 2012, Chilian William M, Collateral Circulation/*physiology, Coronary Artery Disease/physiopathology/therapy, Coronary Circulation/physiology, Department of Integrative Medical Sciences, Dong Feng, Humans, Journal of molecular and cellular cardiology, Logan Suzanna, Mayorga Maritza, Myocardial Ischemia/physiopathology/therapy, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Penn Marc S, Physiologic/physiology, Pung Yuh Fen, Yin Liya

Vascular precursor cells in tissue injury repair.

Vascular precursor cells include stem cells and progenitor cells giving rise to all mature cell types in the wall of blood vessels. When tissue injury occurs, local hypoxia and inflammation result in the generation of vasculogenic mediators which…

Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer.

Breast cancer is the leading cause of cancer-related deaths for women in the United States and the rest of the world. About 8% of women develop breast cancer during the course of their lives. Dietary habits are closely associated with both the risk…

Tags: *Diet, 2012, Anticarcinogenic Agents/*chemistry/*pharmacology, Bishayee Anupam, Breast Neoplasms/*blood supply/*prevention & control, Female, Gopalan Ashwin, Humans, Malus/chemistry, Molecular nutrition & food research, Neovascularization, Pathologic/metabolism/prevention & control, Petit Danielle M, Reuben Sharon C

Browse Items (18 total)