Browse Items · NEOMED Bibliography Database

Myocardial ischemia: From disease to syndrome.

Although current guidelines on the management of stable coronary artery disease acknowledge that multiple mechanisms may precipitate myocardial ischemia, recommended diagnostic, prognostic and therapeutic algorithms are still focused on obstructive…

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.

OBJECTIVE: We have previously found abrogated ischemia-induced coronary collateral growth in Zucker obese fatty (ZOF) rats compared with Zucker lean (ZLN) rats. Because ZOF rats have structural abnormalities in their mitochondria suggesting…

Tags: 2012, Animal, Animals, Antioxidants/*pharmacology, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Collateral Circulation/*drug effects/physiology, Coronary Vessels/drug effects/*growth & development, Department of Integrative Medical Sciences, Disease Models, Guarini Giacinta, Hafemeister Jennifer, Heart/*drug effects/physiology, Lipid Peroxidation/drug effects/physiology, Lipid Peroxides/metabolism, Male, Metabolic Syndrome/*metabolism/physiopathology, Mitochondria, Mitochondrial Proteins/metabolism, Murphy Michael P, NEOMED College of Medicine, Obesity/*metabolism/physiopathology, Ohanyan Vahagn, Organophosphorus Compounds/pharmacology, Oxidative Stress/*drug effects/physiology, Piperidines/pharmacology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Rocic Petra, Smith Robin A J, Ubiquinone/pharmacology, Yin Liya, Zucker

Endothelin-mediated in vivo pressor responses following TRPV1 activation.

Transient receptor potential vanilliod 1 (TRPV1) channels have recently been postulated to play a role in the vascular complications/consequences associated with diabetes despite the fact that the mechanisms through which TRPV1 regulates vascular…

Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.

We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent coronary function is compromised in pigs with metabolic syndrome (MetS). However, the mechanisms through which TRPV1 channels couple coronary blood…

Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known…

Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we…

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