Browse Items (77 total)
- Tags: Disease Models
Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Tags: 2018, Administration, Alboslemy Talib, Animal, Animals, Cell Communication/*physiology, Cell Differentiation, Cells, Cultured, Cutaneous, Diabetes Mellitus, Disease Models, Eye Proteins/administration & dosage/genetics/*physiology, Humans, Inbred C57BL, Kim Min-Ho, Macrophages/*physiology, Male, Membrane Glycoproteins/administration & dosage/genetics/*physiology, Mesenchymal Stem Cells/*physiology, Mice, Recombinant Proteins/administration & dosage/genetics/metabolism, Safadi Fayez, Skin/*injuries/metabolism, The Journal of investigative dermatology, Type 2/complications/pathology, Wound Healing/*physiology, Yu Bing
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.
Tags: *Signal Transduction, 2018, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*antagonists & inhibitors/pharmacology, Department of Integrative Medical Sciences, Disease Models, Ferrell Jessica M, G-Protein-Coupled/*metabolism, Gastrointestinal Microbiome/*drug effects, Glucagon-Like Peptide 1/metabolism, Gonzalez Frank J, GTP-Binding Proteins/*metabolism, Hepatology (Baltimore, Md.), Inbred C57BL, Krausz Kristopher W, Lipid Metabolism, Male, Mice, NEOMED College of Medicine, Nichols Robert G, Pathak Preeti, Patterson Andrew D, Random Allocation, Receptors, Sensitivity and Specificity, Xie Cen
Origins of spondyloarthropathy in Perissodactyla.
Tags: *Fossils, *Paleopathology, *Perissodactyla, 2001, Ancient, Animal, Animals, Ankylosing/history/*pathology, Clinical and experimental rheumatology, Disease Models, History, Horse Diseases/history/*pathology, Horses, North America, Prothero D R, Rothschild B M, Rothschild C, Sacroiliac Joint/pathology, Spine/pathology, Spondylitis
Sex steroid induction of gallstones in the male Syrian hamster.
Tags: 1993, Animal, Animals, Body Weight, Cholelithiasis/*etiology, Cricetinae, Disease Models, Drug Combinations, Endoplasmic Reticulum/drug effects/ultrastructure, Estradiol/*pharmacology, Gallbladder/*drug effects/ultrastructure, Gilloteaux J, Golgi Apparatus/drug effects/ultrastructure, Journal of submicroscopic cytology and pathology, Kelly T R, Kosek E, Male, Medroxyprogesterone/*pharmacology, Mesocricetus, Organ Size
Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.
Tags: 2000, Animal, Corpus Striatum/pathology/*physiopathology, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/*pharmacology, Female, Humans, Male, McDermott J L, Neurotoxins/*antagonists & inhibitors, Parkinson Disease/metabolism/pathology/*physiopathology, Postmenopause, Sex Distribution, Sex Factors, Substantia Nigra/pathology/*physiopathology, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
Estrogen decreases corpus striatal neurotoxicity in response to
Tags: 1997, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animal, Animals, Brain research, Corpus Striatum/*drug effects, Disease Models, Dluzen D, Dopamine/metabolism, Estradiol/*pharmacology, Female, Neurotoxins/*toxicity, Oxidopamine/*toxicity, Parkinson Disease/*physiopathology, Rats, Sprague-Dawley
Intrastrain variants of herpes simplex virus type 1 isolated from a neonate with fatal disseminated infection differ in the ICP34.5 gene, glycoprotein processing, and neuroinvasiveness.
Tags: *Genetic Variation, *Protein Processing, 1999, Amino Acid, Amino Acid Sequence, Animal, Animals, Base Sequence, Bower J R, Deoxyribonuclease BamHI, Deoxyribonuclease EcoRI, Detwiler M, Disease Models, DNA, Durishin C, Genes, Glycoproteins/metabolism, Herpesvirus 1, Human/*genetics/growth & development/isolation & purification, Humans, Inbred BALB C, Journal of virology, Karban T L, Male, Mao H, Mice, Molecular Sequence Data, Nucleic Acid, Polymerase Chain Reaction/methods, Polymorphism, Post-Translational, Rempinski D, Restriction Fragment Length, Rosenthal K S, Rozenbom E, Sequence Analysis, Sequence Homology, Viral, Viral Envelope Proteins/analysis, Viral Proteins/*genetics
Functional outcome after anal sphincter injury and treatment with mesenchymal stem cells.
Tags: *Mesenchymal Stem Cell Transplantation, *Regeneration, 2014, Anal Canal/injuries/metabolism/pathology/physiopathology/*surgery, Anal pressures, Anal sphincter, Animal, Animals, Balog Brian, Cells, Cultured, Damaser Margot, Disease Models, Fecal incontinence, Female, Fibrosis, Green Fluorescent Proteins/biosynthesis/genetics, i.v. infusion, Infusions, Injections, Intralesional, Intravenous, Mesenchymal stem cells, Mesenchymal Stem Cells/metabolism, Penn Marc, Pressure, Rats, Recovery of Function, Salcedo Levilester, Sprague-Dawley, Stem cells translational medicine, Time Factors, Transfection, Zutshi Massarat
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor
Tags: *Drug Delivery Systems, 2013, Animal, Animals, Benzodioxoles/*administration & dosage/pharmacokinetics/toxicity, Bhatia Deepak, Body Temperature, Delayed-Action Preparations, Disease Models, Drug Carriers/chemistry/toxicity, Fibroblasts/drug effects/metabolism, Filtering Surgery/*methods, Geldenhuys Werner, Gels, Glaucoma/*surgery, Imidazoles/*administration & dosage/pharmacokinetics/toxicity, Miladore Nicholas, Nakamura Hiroshi, Pharmaceutical development and technology, Poloxamer/chemistry/toxicity, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Pyridines/*administration & dosage/pharmacokinetics/toxicity, Rabbits, Receptor, Receptors, Sutariya Vijaykumar, Temperature, Time Factors, Transforming Growth Factor beta/antagonists & inhibitors, Transforming Growth Factor-beta Type I, Viscosity, Wehrung Daniel
Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice.
Tags: 2016, Animal, Animals, Aorta, Benzofurans/chemistry/*pharmacology, Blood Pressure/drug effects, Brain/blood, Cardiac/cytology/drug effects/metabolism, Cell Line, Chen Renshan, Chinese Herbal/chemistry/pharmacology, Disease Models, Drugs, GATA4 Transcription Factor/metabolism, Gu Weiwang, Heart Failure/metabolism/*pathology, Heart Ventricles/diagnostic imaging, Inbred C57BL, Male, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Myocardium/metabolism/pathology, Myocytes, Natriuretic Peptide, Phosphorylation/drug effects, PloS one, Proto-Oncogene Proteins c-akt/metabolism, Qi Jianyong, Rats, Signal Transduction/*drug effects, Tan Yafang, Thoracic/surgery, Wu Jiashin, Yu Juan, Zhang Minzhou
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Askew Michael J, Biomechanical Phenomena, Body Weight/drug effects, Bone and Bones/drug effects, Bone/prevention & control, Collagen Type I, Collagen/genetics, Densitometry, Department of Family & Community Medicine, Disease Models, Femur/drug effects/pathology, Fractures, Growth Hormone/*therapeutic use, Heterozygote, Humans, Inbred C57BL, Jarjoura David, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, King Donna, Lumbar Vertebrae/drug effects, McEwen Heather A, Mice, Mutation, NEOMED College of Medicine, Osteoblasts/*drug effects/metabolism, Osteogenesis Imperfecta/*drug therapy, Phenotype, Time Factors, Transgenic
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.
Tags: *2H2O-labeling, *Brain, *Genetic Variation, *Histone, *Mass spectrometry, *Post-translational modifications, *Postnatal alcohol exposure, *Turnover, 2017, Acetylation, Animal, Animals, Cell Proliferation, Clinical epigenetics, Department of Pharmaceutical Sciences, Disease Models, DNA Damage, Epigenesis, Female, Fetal Alcohol Spectrum Disorders/genetics/*metabolism, Genetic, Histones/*genetics/*metabolism, Humans, Kasumov Takhar, Li Ling, NEOMED College of Pharmacy, Post-Translational, Pregnancy, Previs Stephen, Protein Processing, Proteomics/*methods, Rachdaoui Nadia, Rats, Sarkar Dipak, Sprague-Dawley, Willard Belinda
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Tags: *Alzheimers disease, *Immunity, *Inflammation, *Tauopathy, *TREM2, 2017, Allan Kevin, Animal, Animals, Bemiller Shane M, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Formica Shane V, Humans, Immunologic/*deficiency, Inbred C57BL, Kokiko-Cochran Olga N, Lamb Bruce T, Landreth Gary E, Lasagna-Reeves Cristian A, McCray Tyler J, Membrane Glycoproteins/*deficiency, Mice, Microglia/metabolism, Molecular neurodegeneration, NEOMED College of Pharmacy, Protein Kinases/*metabolism, Ransohoff Richard M, Receptors, Signal Transduction/physiology, tau Proteins/*metabolism, Tauopathies/metabolism/*pathology, Transgenic, Wilson Gina, Xu Guixiang
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Tags: 2018, Alzheimer's disease, Animal, Animals, Antigens, Bemiller Shane M, Bhaskar Kiran, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cannon Judy L, Cardona Astrid E, Cells – Drug Effects, Cells – Metabolism, Cells – Pathology, Chemokine CX3CL1/*genetics/metabolism, Cognition Disorders – Etiology, Cognition Disorders/etiology, Crish Samuel D, CX3CL1, CX3CR1, Cytokines, Cytokines – Metabolism, Cytokines/metabolism, Department of Pharmaceutical Sciences, Differentiation/genetics/metabolism, Disease Models, Formica Shane V, Gene Expression Regulation/drug effects/*genetics, Genes, Genes – Drug Effects, Journal of neuroinflammation, Jung Steffen, Kim Ki-Wook, Kokiko-Cochran Olga N, Lamb Bruce T, Learning, Lipopolysaccharides, Lipopolysaccharides/toxicity, Maphis Nicole M, Maze Learning, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia, Microglia/drug effects/*metabolism/pathology, Miller Crystal M, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurodegenerative Diseases – Pathology, Neuroinflammation, Surface, Surface – Metabolism, Tau, tau Proteins/genetics/metabolism, Tauopathies, Tauopathies/complications/genetics/*pathology, Transgenic, Wilson Gina N, Xu Guixiang
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
Tags: 2008, Animal, Animals, Brain Injuries/blood/epidemiology/genetics/*physiopathology, Cerebral Cortex/physiopathology, Chemokine CCL2/genetics/physiology, Chemokines/*genetics, Cytokines/*antagonists & inhibitors, Disease Models, Hippocampus/physiopathology, Inflammation/genetics/*physiopathology, Interleukin-1beta/genetics/physiology, Interleukin-6/genetics/physiology, Journal of neuroinflammation, Lloyd Eric, Male, Mice, Somera-Molina Kathleen, Tumor Necrosis Factor-alpha/genetics/physiology, United States/epidemiology, Up-Regulation, Van Eldik Linda J, Wainwright Mark S, Watterson D Martin
Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema.
Tags: 1998, Adrenal Glands/*metabolism, Adrenalectomy, Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use, Adrenergic beta-Antagonists/therapeutic use, American journal of respiratory and critical care medicine, Amiloride/therapeutic use, Animal, Animals, Awender N E, Blood, Blood Pressure, Brain Diseases/chemically induced/*complications, Central Nervous System Agents/adverse effects, Cisterna Magna, Disease Models, Diuretics/therapeutic use, Dogs, Epinephrine/blood/*physiology/therapeutic use, Extravascular Lung Water/chemistry/*metabolism, Female, Hypertension, Injections, Lane S M, Maender K C, Male, Maron M B, Propanolamines/therapeutic use, Proteins/analysis, Pulmonary Alveoli/*metabolism, Pulmonary Artery, Pulmonary Edema/etiology/*metabolism/prevention & control, Pulmonary/prevention & control, Sodium Channel Blockers, Veratrine/adverse effects
Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction.
Tags: 2012, Adapala Ravi K, Animal, Animals, Apoptosis/physiology, Bonaldo Paolo, Cardiac/pathology/physiology, Chilian William M, Circulation research, Collagen Type VI/*genetics/*metabolism, Department of Integrative Medical Sciences, Disease Models, Echocardiography, Extracellular Matrix/metabolism/pathology, Fibrosis/genetics/pathology/physiopathology, Hodnichak Cheryl, Knockout, Luther Daniel J, Male, Meszaros J Gary, Mice, Myocardial Infarction/diagnostic imaging/*genetics/*physiopathology, Myocytes, NEOMED College of Medicine, Shamhart Patricia E, Thodeti Charles K, Ventricular Remodeling/*physiology, Weihrauch Dorothee
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.
Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya
Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation.
Tags: *Catheter Ablation, 2014, Acetylcholine, Action Potentials, Animal, Animal Studies, Animals, Artificial, Atrial fibrillation, Atrial Fibrillation – Etiology, Atrial Fibrillation – Physiopathology, Atrial Fibrillation – Prevention and Control, Atrial Fibrillation/etiology/physiopathology/*prevention & control, Biological, Body Surface Potential Mapping, Cardiac Pacing, Catheter Ablation, Circulation. Arrhythmia and electrophysiology, coronary sinus, Coronary Sinus/physiopathology/*surgery, Coronary Vessels – Physiopathology, Coronary Vessels – Surgery, Disease Models, Dogs, Heart Atria/physiopathology/surgery, Heart Atrium – Physiopathology, Heart Atrium – Surgery, Male, Models, Morita Hiroshi, Morita Shiho T, optical Vm mapping, Time Factors, Wu Jiashin, Zipes Douglas P
Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.
Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya
Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats.
Tags: 2012, Animal, Animals, Antioxidants/*pharmacology, Arteriosclerosis, thrombosis, and vascular biology, Chilian William M, Collateral Circulation/*drug effects/physiology, Coronary Vessels/drug effects/*growth & development, Department of Integrative Medical Sciences, Disease Models, Guarini Giacinta, Hafemeister Jennifer, Heart/*drug effects/physiology, Lipid Peroxidation/drug effects/physiology, Lipid Peroxides/metabolism, Male, Metabolic Syndrome/*metabolism/physiopathology, Mitochondria, Mitochondrial Proteins/metabolism, Murphy Michael P, NEOMED College of Medicine, Obesity/*metabolism/physiopathology, Ohanyan Vahagn, Organophosphorus Compounds/pharmacology, Oxidative Stress/*drug effects/physiology, Piperidines/pharmacology, Pung Yuh Fen, Rats, Reactive Oxygen Species/metabolism, Rocic Petra, Smith Robin A J, Ubiquinone/pharmacology, Yin Liya, Zucker
The mechanistic basis for the disparate effects of angiotensin II on coronary collateral growth.
Tags: 2008, Angiotensin, Angiotensin II/*physiology, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Coronary Occlusion/drug therapy/*physiopathology, Disease Models, Hemorheology, Ischemia/drug therapy/*physiopathology, Kolz Christopher, Male, Neovascularization, Oxidative Stress/*physiology, Physiologic/*physiology, Potter Barry, Rats, Reactive Oxygen Species/adverse effects/metabolism, Receptor, Reed Ryan, Rocic Petra, Type 1/*drug effects/physiology, Vasoconstrictor Agents/pharmacology
LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model.
Tags: *Cancer Vaccines/genetics/immunology/therapeutic use, 2017, Animal, Animals, Breast Neoplasms/genetics/immunology/prevention & control/therapy, CD8-Positive T-Lymphocytes/immunology, Cell Line, Cytotoxic/immunology, Disease Models, Disease Progression, Epitopes, erbB-2, Experimental/immunology/pathology/*prevention & control/*therapy, Female, Genes, Immunoglobulin G/blood, Inbred BALB C, Journal of immunology research, Koski Gary, Mammary Neoplasms, Mice, Neoplasm Metastasis/prevention & control, Proof of Concept Study, Rosenthal Ken S, Stone Sarah, T-Lymphocyte/immunology, T-Lymphocytes, Tumor, Zimmerman Daniel H
Weighted Lin-Wang tests for crossing hazards.
Tags: *Survival Analysis, 2014, Algorithms, Animal, Animals, Computational and mathematical methods in medicine, Computer Simulation, Data Interpretation, Disease Models, Humans, Jia Zhenyu, Kaplan-Meier Estimate, Koziol James A, Leukemia/drug therapy, Mice, Models, Reproducibility of Results, Statistical
Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.
Tags: 1990, Animal, Animals, Catecholamines/physiology, Disease Models, Dogs, Female, Hypertension, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Perfusion, Pulmonary Circulation/drug effects/*physiology, Pulmonary Edema/chemically induced/*physiopathology, Pulmonary/chemically induced/physiopathology, Splenectomy, Sympathetic Nervous System/drug effects/physiopathology, Vasoconstriction/drug effects/*physiology, Veratrine
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Tags: *Collateral Circulation/drug effects, *Coronary Circulation/drug effects, *MAP Kinase Signaling System/drug effects, 2007, Acetophenones/pharmacology, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Blood Flow Velocity, Cells, Chilian William M, Coronary Vessels/surgery, Cultured, Department of Integrative Medical Sciences, Disease Models, Ditiocarb/pharmacology, Endothelial Cells/drug effects/enzymology/*metabolism, Enzyme Inhibitors/pharmacology, Humans, Imidazoles/pharmacology, Inbred WKY, Kolz Christopher, Ligation, Male, Myocardial Reperfusion Injury/enzymology/metabolism/*physiopathology, NADPH Oxidases/antagonists & inhibitors/metabolism, NEOMED College of Medicine, Neovascularization, Onium Compounds/pharmacology, Oxygenases/antagonists & inhibitors/metabolism, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism, Physiologic, Potter Barry, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reed Ryan, Rocic Petra, Superoxide Dismutase/antagonists & inhibitors/metabolism, Vascular Endothelial Growth Factor A/metabolism
The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.
Tags: *Rats, 2017, American journal of physiology. Heart and circulatory physiology, Animal, Animals, Aortic Aneurysm, Atherosclerosis/pathology, Bennett Martin R, Blood Glucose/metabolism, Blood Vessels/pathology, Body Weight, Chilian William M, Collagen/biosynthesis, Cysts/*genetics/pathology, Department of Integrative Medical Sciences, Disease Models, Figg Nichola, hypoxia, Inbred Strains, Kamarulzaman Mohd Hamzah, leptin, Lipids/blood, Male, Metabolic syndrome, Metabolic Syndrome/*genetics/pathology, Necrosis, NEOMED College of Medicine, Proteoglycans/biosynthesis, Pung Yuh Fen, Rats, rodent model, Thoracic/*genetics/pathology
Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardial infarction.
Tags: 2016, alpha Subunit/metabolism, American journal of physiology. Heart and circulatory physiology, Amino Acids, Animal, Animals, Apoptosis/drug effects, Cardiotonic Agents/*pharmacology, Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, Dicarboxylic/*pharmacology, Disease Models, Dong Feng, Enzyme Inhibitors/pharmacology, Forudi Farhad, hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred C57BL, Kiedrowski Matthew, Knockout, Left/*drug effects, Mayorga Mari, Mice, myocardial infarction, Myocardial Infarction/*drug therapy/genetics/metabolism/pathology/physiopathology, Myocardium/*metabolism/pathology, NEOMED College of Medicine, Penn Marc S, Rats, Receptors, Recovery of Function, Shamhart Patricia, Signal Transduction/drug effects, stem cells, Stem Cells/drug effects/metabolism, Stroke Volume/drug effects, Time Factors, Up-Regulation, Ventricular Function, Weber Kristal
Endothelin-mediated in vivo pressor responses following TRPV1 activation.
Tags: *Blood Pressure/drug effects, *Vasoconstriction/drug effects, 2011, Adrenergic alpha-Agonists/administration & dosage, American journal of physiology. Heart and circulatory physiology, Analysis of Variance, Animal, Animals, Azepines/administration & dosage, Biphenyl Compounds/administration & dosage, Bratz Ian N, Capsaicin/administration & dosage, Cells, Cultured, Damron Derek S, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Angiopathies/genetics/*metabolism/physiopathology, Dipeptides/administration & dosage, Disease Models, Dose-Response Relationship, Drug, Endothelial Cells/metabolism, Endothelin A Receptor Antagonists, Endothelin A/metabolism, Endothelin B Receptor Antagonists, Endothelin B/metabolism, Endothelin-1/*metabolism, Enzyme-Linked Immunosorbent Assay, Femoral Artery/drug effects/*metabolism/physiopathology, Guarini Giacinta, Haney Rebecca M, Inbred C57BL, Indoles/administration & dosage, Infusions, Intravenous, Knockout, Male, Meszaros J Gary, Mice, NEOMED College of Medicine, Ohanyan Vahagn A, Phenylephrine/administration & dosage, Raman Priya, Receptor, Talasila Phani K, Thodeti Charles K, TRPV Cation Channels/agonists/deficiency/genetics/*metabolism, Type 2/genetics/*metabolism/physiopathology, Vasoconstrictor Agents/administration & dosage
Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration.
Tags: *alcohol, *bacteremia, *cell signaling, *granulocytes, *granulopoietic response, *Stem cells, 2017, Animal, Animals, Antigens, Bacteremia/genetics/*immunology/pathology, Binge Drinking/genetics/*immunology/pathology, Bone Marrow Cells/drug effects/immunology/pathology, CCAAT-Enhancer-Binding Protein-beta/genetics/immunology, Cyclin D1/genetics/immunology, Department of Integrative Medical Sciences, Disease Models, Escherichia coli Infections/genetics/*immunology/pathology, Escherichia coli/growth & development/immunology, Ethanol/*pharmacology, Gao Bin, Gene Expression Regulation/*drug effects/immunology, Granulocytes/drug effects/immunology/pathology, Hematopoiesis/*drug effects/genetics/immunology, Inbred BALB C, Infection and immunity, Lin Yuan-Ping, Ly/genetics/immunology, Male, Membrane Proteins/genetics/immunology, Mice, Mitogen-Activated Protein Kinase 1/genetics/immunology, Mitogen-Activated Protein Kinase 3/genetics/immunology, NEOMED College of Medicine, Nucleotidyltransferases/deficiency/genetics/immunology, Proto-Oncogene Proteins c-kit/genetics/immunology, Shi Xin, Signal Transduction/*drug effects/immunology, Toll-Like Receptor 4/genetics/immunology, Zhang Ping
Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease.
Tags: 2007, Animal, Animals, Basal Ganglia/drug effects/*metabolism/pathology, Clinical and experimental pharmacology & physiology, Disease Models, Dluzen Dean E, Dopamine/*metabolism, Estrogens/*metabolism/pharmacology/therapeutic use, Humans, Liu Bin, Nerve Degeneration/drug therapy/*metabolism/pathology, Neurons/metabolism/pathology, Neuroprotective Agents/*metabolism/pharmacology/therapeutic use, Parkinson Disease/drug therapy/*metabolism/pathology, Parkinsonian Disorders/drug therapy/*metabolism/pathology, Substantia Nigra/drug effects/*metabolism/pathology
Intestinal Flora Modification of Arthritis Pattern in Spondyloarthropathy.
Tags: *Bacteria/classification/genetics/isolation & purification, *Diarrhea/complications/microbiology, *Gastrointestinal Microbiome, *Spondylarthropathies/diagnosis/etiology/physiopathology, 16S/analysis, 2015, Animal, Animals, Disease Models, Gastrointestinal Tract/*microbiology, Gorilla gorilla, Humans, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, Pan troglodytes, Protective Factors, Ribosomal, RNA, Rothschild Bruce M
Effects of growth hormone transgene expression on vertebrae in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Beamer Wesley G, Biomechanical Phenomena, Bone Density, Chase Jeff, Department of Family & Community Medicine, Disease Models, Female, Gene Expression, Genetic Therapy/*methods, Havey Robert M, Heterozygote, Human Growth Hormone/*genetics, Humans, Inbred C57BL, King Donna, Male, McEwen Heather A, Mice, NEOMED College of Medicine, Osteogenesis Imperfecta/pathology/physiopathology/*therapy, Patwardhan Avinash G, Sartori Mark, Spine, Spine/pathology/*physiology, Tail, Transgenic, Voronov Leonard
Lack of bone stiffness/strength contribution to osteoarthritis–evidence for primary role of cartilage damage.
Tags: 2007, Animal, Animals, Articular/physiopathology, Biomechanical Phenomena, Bird Diseases/*physiopathology, Birds, Bone and Bones/*physiopathology, Cartilage, Disease Models, Mechanical, Osteoarthritis/*physiopathology/*veterinary, Panza R K, Rheumatology (Oxford, England), Rothschild B M, Species Specificity, Stress
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.
Tags: 2016, Animal, Animals, Blackwood Rachel, Calcium Signaling/genetics, Dantrolene/*administration & dosage, Dasgupta Nupur, Department of Pharmaceutical Sciences, Disease Models, Fleming Sheila, Gaucher Disease/*drug therapy/genetics/physiopathology, Grabowski Gregory A, Human molecular genetics, Humans, Inskeep Venette, Li Ronghua, Liou Benjamin, Marshall John, Mice, Mitochondria/*drug effects/genetics/pathology, NEOMED College of Pharmacy, Neurons/drug effects/pathology, Neuroprotective Agents/administration & dosage, Peng Yanyan, Quinn Brian, Ryanodine Receptor Calcium Release Channel/*genetics/metabolism, Setchell Kenneth D R, Sun Ying, Zhang Wujuan
Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease.
Tags: 2016, Alzheimer Disease/etiology/*metabolism/pathology, Alzheimer's disease, Amyloid beta-Peptides/*metabolism, Animal, Animal/physiology, Animals, Behavior, Bemiller Shane M, Bhaskar Kiran, Blotting, Brain Injuries, Brain/*metabolism/pathology, Crish Samuel, Department of Pharmaceutical Sciences, Disease Models, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Inbred C57BL, Inflammation/*metabolism/pathology, Journal of neurotrauma, Kokiko-Cochran Olga N, Lamb Bruce T, Lee Sungho, Lee Yu-Shang, macrophage, Mice, NEOMED College of Pharmacy, Neuroinflammation, Ransohoff Lena, Ransohoff Richard M, Saber Maha, Sikora Matt, Teknipp Ryan, Transgenic, Traumatic brain injury, Traumatic/complications/*metabolism/*pathology, Veenstra Mike, Western, Wilson Gina, Xu Guixiang