Browse Items (42 total)
- Tags: Sex Factors
Tags: 2003, 80 and over, Age Factors, Aged, Analysis of Covariance, Analysis of Variance, Baum EE, Clinical Assessment Tools, Clinical Trials, Confidence Intervals, Crossover Design, Data Analysis Software, Descriptive Statistics, Faur D, Female, Frail Elderly, Functional Status, Geriatric Functional Assessment, Gerontologic Care, Group Exercise – In Old Age, Housing for the Elderly, Human, Inpatients, Jarjoura D, Journal of the American Medical Directors Association, Long Term Care, Male, Muscle Strengthening, Nursing Homes, Outcomes (Health Care), P-Value, Patient Compliance, Pilot Studies, Pliability, Polen AE, Prospective Studies, Random Assignment, Range of Motion, Recreation, Repeated Measures, Rutechi G, Sensitivity and Specificity, Sex Factors, Summated Rating Scaling, Treatment Outcomes
Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.
Tags: 2000, Basal Ganglia – Pathology, Basal Ganglia – Physiopathology, Brain Stem – Pathology, Brain Stem – Physiopathology, Dluzen D E, Dopamine – Metabolism, Estrogens – Pharmacodynamics, Female, Gender Specific Care, Journal of Gender-Specific Medicine, Male, McDermott J L, Parkinson Disease – Metabolism, Parkinson Disease – Pathology, Parkinson Disease – Physiopathology, Postmenopause, Sex Factors, Toxins
Tags: 2006, Adolescence, Adult, Age Factors, Child, Cleft Lip, Cleft Palate, Cleft Palate-Craniofacial Journal, Confidence Intervals, Descriptive Statistics, Female, Fox L, Hospitals, Human, Infant, Lehman J, Male, Middle Age, Mouth Abnormalities – Surgery, Murthy AS, Ohio, Parker M G, Pediatric – Ohio, Pharyngeal Diseases – Surgery, Pharynx – Surgery, Preschool, Prospective Studies, Pryor LS, Record Review, Reoperation, Retrospective Design, Risk Factors, Sample Size, Schmidt A, Sex Factors, Speech, Surgical Flaps, T-Tests, Treatment Outcomes
Inhaled corticosteroid use in asthmatic children receiving Ohio Medicaid: trend analysis, 1997-2001.
Tags: 2008, Administration, Adolescence, Adrenal Cortex Hormones – Administration and Dosage, Adrenal Cortex Hormones – Therapeutic Use, Ambulatory Care – Statistics and Numerical Data, Annals of Allergy, Asthma & Immunology, Asthma – Diagnosis, Asthma – Drug Therapy, Asthma – Ethnology, Bean JA, Blacks – Statistics and Numerical Data, Child, Cross Sectional Studies, Drug Utilization – Statistics and Numerical Data, Drug Utilization – Trends, Emergency Service – Statistics and Numerical Data, Female, Heaton PC, Hospitalization – Statistics and Numerical Data, Human, Infant, Inhalation, Male, Medicaid – Statistics and Numerical Data, Moomaw CJ, Newborn, Ohio, Preschool, Regression, Retrospective Design, Ruddy RM, Sex Factors, Stevenson MD, United States, Whites – Statistics and Numerical Data
Tags: 2008, Animal Studies, Animals, Central Nervous System Stimulants – Pharmacodynamics, Central Nervous System Stimulants – Pharmacokinetics, Depression – Drug Therapy, Dluzen D E, Female, Gender Identity, Gender medicine, Liu B, Male, Methamphetamine – Pharmacodynamics, Methamphetamine – Pharmacokinetics, Reproduction, Sex Factors, Substance Use Disorders
Expression of hepatic microsomal cholesterol 7 alpha-hydroxylase activity in lean and obese Zucker rats.
Tags: 1988, Animals, Biochemical and biophysical research communications, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*metabolism, Cholestyramine Resin/pharmacology, Department of Integrative Medical Sciences, Female, Finkelstein J A, Liver/*enzymology, Male, Microsomes, NEOMED College of Medicine, Obesity/*metabolism, Rats, Sex Factors, Species Specificity, Steroid Hydroxylases/*metabolism, Tang P M, Zucker/metabolism
Tags: 1988, American family physician, Anorexia Nervosa/*drug therapy/psychology, Antidepressive Agents, Behavior Therapy, Bulimia/*drug therapy/psychology, Combined Modality Therapy, Female, Humans, Male, Monoamine Oxidase Inhibitors/therapeutic use, Price W A, Sex Factors, Tricyclic/*therapeutic use
Tags: *Family Practice, *Primary Health Care, 1992, Adult, Age Factors, Benken D, Body Mass Index, Dennis L K, Female, Humans, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Iverson D C, Male, McArtor R E, Medical Records, Middle Aged, Motivation, Obesity/epidemiology/*therapy, Prevalence, Risk Factors, Self Care, Sex Factors
Differences in the preparation and practice of male and female physicians from combined baccalaureate–MD degree programs.
Tags: *Attitude of Health Personnel, *Physicians, 2000, Analysis of Variance, Arnold L, Education, Epstein L C, Female, Humans, Jones B J, Journal of the American Medical Women's Association (1972), Male, Medical, Premedical/*standards, Professional Practice/*standards, Sex Factors, Surveys and Questionnaires, Undergraduate/*standards, United States, Women, Xu G
Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.
Tags: 2002, Anderson Linda I, Animals, Body Temperature/drug effects, Body Weight/drug effects, Corpus Striatum/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Drug Interactions, Estrogens/pharmacology/*physiology, Female, Heart Rate/drug effects, Heart Ventricles/metabolism, Inbred Strains, Male, Methamphetamine/*toxicity, Mice, Neurotoxicology and teratology, Norepinephrine/metabolism, Orchiectomy, Organ Size/drug effects, Ovariectomy, Pilati Charles F, Pituitary Gland/anatomy & histology, Sex Factors, Testosterone/pharmacology/*physiology
Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.
Tags: 2000, Animal, Corpus Striatum/pathology/*physiopathology, Disease Models, Dluzen D E, Dopamine/metabolism, Estrogens/*pharmacology, Female, Humans, Male, McDermott J L, Neurotoxins/*antagonists & inhibitors, Parkinson Disease/metabolism/pathology/*physiopathology, Postmenopause, Sex Distribution, Sex Factors, Substantia Nigra/pathology/*physiopathology, The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
To stay or not to stay: factors influencing family practice residents' choice of initial practice location.
Tags: *Family Practice, *Professional Practice Location/statistics & numerical data/trends, 1996, Adult, Age Factors, Analysis of Variance, Costa A J, Data Collection, family medicine, Female, Gillanders W R, Humans, Internship and Residency, Life Style, Logistic Models, Male, McCord G, Schrop S L, Sex Factors, Workforce
A biopsychosocial profile of the geriatric population who frequently visit the emergency department.
Tags: *Aged/psychology, 1991, African Americans, Brokaw M, Demography, Emergency Service, European Continental Ancestry Group, Female, Hospital/*statistics & numerical data, Humans, Male, Marriage, Ohio medicine : journal of the Ohio State Medical Association, Ohio/epidemiology, Retrospective Studies, Sex Factors, Zaraa A S
Tags: *Health Knowledge, 2015, Adolescent, adolescents, Age Factors, Attitudes, Awareness, Beverages/*adverse effects/statistics & numerical data, caffeine, Caffeine/administration & dosage/*adverse effects, Child, Cross-Sectional Studies, Deoras Ketan, Female, Griffin Catherine, Humans, Incidence, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, Krishna Jyoti, Male, Needs Assessment, Pilot Projects, Podmore Petra, Practice, Risk Assessment, Sex Factors, sleep, Sleep Wake Disorders/*chemically induced/epidemiology, Students/statistics & numerical data, Surveys and Questionnaires, Thakre Tushar P, United States, Vemana Aarthi
Treatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach.
Tags: *Markov Chains, 2014, Aged, Akkineni Roopa, Albert Daniel A, Allopurinol – Therapeutic Use, Allopurinol/*therapeutic use, CARDIOVASCULAR DISEASE, Choi Hyon K, DECISION ANALYSIS, Decision Support Techniques, Female, Follow-Up Studies, Gout Suppressants – Therapeutic Use, Gout Suppressants/*therapeutic use, Human, Humans, HYPERURICEMIA, Hyperuricemia – Complications, Hyperuricemia – Diagnosis, Hyperuricemia – Drug Therapy, Hyperuricemia/complications/*diagnosis/*drug therapy, Lee Alexandra, Male, Middle Age, Middle Aged, Miller Katherine L, Probability, Prospective Studies, Risk Assessment, Severity of Illness Index, Severity of Illness Indices, Sex Factors, Tapp Stephanie, The Journal of rheumatology, Tosteson Anna N A, Treatment Outcome, Treatment Outcomes, Uric Acid – Blood, Uric Acid/blood, Vascular Diseases – Etiology, Vascular Diseases – Prevention and Control, Vascular Diseases/etiology/*prevention & control, Zhu Yanyan
Tags: 2014, 80 and over, Accidental Falls/*statistics & numerical data, Aged, Al Snih Soham, Clinical interventions in aging, Cognition, Cognition Disorders/epidemiology/*etiology, Depression, Depression/epidemiology/etiology, Educational Status, Elderly, Female, Hand Strength, Humans, Male, Markides Kyriakos S, Mexican Americans/psychology/*statistics & numerical data, Neuropsychological Tests, Ottenbacher Kenneth J, Padubidri Anokha, Psychiatric Status Rating Scales, Raji Mukaila A, Samper-Ternent Rafael, Sex Factors, United States/epidemiology
Tags: 2006, Adolescent, Adult, Age Factors, Child, Cleft Lip/*surgery, Cleft Palate/*surgery, Female, Fox Lynn, Humans, Infant, Lehman James, Male, Middle Aged, Murthy Ananth S, Parker Michael G, Pharynx/*surgery, Preschool, Pryor Landon S, Retreatment/statistics & numerical data, Retrospective Studies, Risk Factors, Schmidt Anna, Sex Factors, Speech, The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, Treatment Outcome, Velopharyngeal Insufficiency/*surgery
Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.
Tags: 2012, Adipose Tissue, Adiposity/genetics, Animals, Brown/pathology, Carcinoma/etiology/*genetics, Cell Transformation, Chen Wei-Dong, Cytoplasmic and Nuclear/*deficiency/genetics, Diet, Dietary Fats/metabolism, Edwards Peter A, Energy Metabolism/genetics, Female, Ge Xuemei, Gene Knockout Techniques, Glucose Intolerance/complications/genetics, Heemstra Lydia A, High-Fat/*adverse effects, Intestinal Absorption, Kasim Neda, Knockout, Leptin/deficiency/genetics, Liver Neoplasms/etiology/*genetics, Liver/pathology, Ma Huiyan, Male, Mice, Molecular endocrinology (Baltimore, Md.), Muscle, Neoplastic/genetics, Novak Colleen M, Obese, Obesity/*etiology/genetics, Receptors, Sex Factors, Skeletal/metabolism, Smith Joseph L, Weight Gain/genetics, Xu Jiesi, Zhang Yanqiao
Tags: 2008, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Adrenergic Uptake Inhibitors/metabolism, Animal/drug effects, Animals, Annals of the New York Academy of Sciences, Behavior, Behavior/drug effects, Corpus Striatum/metabolism, Dluzen D E, Dopamine Agents/pharmacology, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine Uptake Inhibitors/metabolism, Female, Humans, Male, McDermott J L, Methamphetamine/pharmacology, Mice, Nomifensine/metabolism, Reserpine/metabolism, Sex Factors, Vesicular Monoamine Transport Proteins/*metabolism
Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system.
Tags: 2003, Anderson Linda I, Animals, Dluzen Dean E, Dopamine/metabolism, Female, Inbred Strains, Laping Nicholas J, Male, Messenger/drug effects, Methamphetamine/*toxicity, Mice, Neostriatum/*drug effects/metabolism, Neurodegenerative Diseases/*chemically induced/genetics, Neuroendocrinology, Neurotoxins/*toxicity, RNA, Sex Factors, Substantia Nigra/*drug effects/metabolism, Tweed Christopher
Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice.
Tags: 2007, Adrenergic Uptake Inhibitors/*metabolism, Animals, Corpus Striatum/anatomy & histology/*metabolism, Dluzen D E, Dopamine Agents/metabolism, Dopamine/*metabolism, Female, Ji J, Journal of neuroendocrinology, Male, McDermott J L, Methamphetamine/metabolism, Mice, Potassium/*metabolism, Reserpine/*metabolism, Sex Factors, Tissue Culture Techniques, Vesicular Monoamine Transport Proteins/metabolism
Tags: *Military Personnel/statistics & numerical data, 2012, Adult, Age Factors, Bader Julia O, Caram Pedro M Jr, Cohort Studies, Databases, Factual, Female, George Alan A, Humans, Incidence, Journal of spinal disorders & techniques, Male, Prospective Studies, Radiculopathy/diagnosis/*epidemiology, Risk Factors, Schoenfeld Andrew J, Sex Factors, United States/epidemiology, Young Adult
Tags: 2004, 80 and over, Age Factors, Aged, Analgesia/statistics & numerical data, Camargo Carlos A Jr, Emergency Medical Services/*statistics & numerical data, Emond Jennifer A, European journal of emergency medicine : official journal of the European Society for Emergency Medicine, Female, Gerson Lowell W, Hip Fractures/diagnosis/*epidemiology/therapy, Humans, Male, Middle Aged, Sex Factors, United States/epidemiology
Tags: *Amphetamine-Related Disorders, *Gender Identity, *Sex Characteristics, 2008, Animals, Central Nervous System Stimulants/pharmacokinetics/*pharmacology, Depressive Disorder/drug therapy, Dluzen Dean E, Female, Gender medicine, Humans, Liu Bin, Male, Methamphetamine/pharmacokinetics/*pharmacology, Sex Factors, Substance-Related Disorders
Inhaled corticosteroid use in asthmatic children receiving Ohio Medicaid: trend analysis, 1997-2001.
Tags: 2008, Administration, Adolescent, Adrenal Cortex Hormones/administration & dosage/*therapeutic use, African Americans/statistics & numerical data, Ambulatory Care/statistics & numerical data, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Asthma/diagnosis/*drug therapy/ethnology, Bean Judy A, Child, Cross-Sectional Studies, Drug Utilization/statistics & numerical data/trends, Emergency Service, European Continental Ancestry Group/statistics & numerical data, Female, Heaton Pamela C, Hospital/statistics & numerical data, Hospitalization/statistics & numerical data, Humans, Infant, Inhalation, Male, Medicaid/*statistics & numerical data, Moomaw Charles J, Newborn, Ohio, Preschool, Regression Analysis, Retrospective Studies, Ruddy Richard M, Sex Factors, Stevenson Michelle D, United States
Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial.
Tags: *Age, *Bone metastases, *Gender, *Pain response, *Quality of Life, *Radiotherapy, *Re-irradiation, 2018, Age Factors, Aged, Babington Scott, Bone Neoplasms/physiopathology/*radiotherapy/*secondary, Brundage Michael, Cancer Pain/etiology/*radiotherapy, Chow Edward, Chow Ronald, Demas William F, Ding Keyue, Female, Ganesh Vithusha, Hartsell William F, Hoskin Peter, Humans, Male, Meyer Ralph M, Middle Aged, Nabid Abdenour, Pain Measurement, Palliative Care/methods/statistics & numerical data, Patient Reported Outcome Measures, Physicians'/*statistics & numerical data, Practice Patterns, Quality of Life, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Re-irradiation, Roos Daniel, Sex Factors, van Acht Manouk, van der Linden Yvette M, Wanders Rinus, Wilson Carolyn F, Wong Rebecca K S, Wu Jackson S Y, Zhu Liting
Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Tags: 2010, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Age Factors, Animals, Body Temperature/drug effects, Central Nervous System Stimulants/*toxicity, Corpus Striatum/*drug effects/metabolism, Darvesh A S, Department of Pharmaceutical Sciences, Dluzen D E, Dopamine/*metabolism, Female, In Vitro Techniques, Male, McDermott J L, Methamphetamine/*toxicity, Mice, NEOMED College of Pharmacy, Neuroscience, Neurotoxicity Syndromes/etiology/*metabolism/physiopathology, Sex Factors, Time Factors
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Tags: 2004, Animals, Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism, Central Nervous System Stimulants/poisoning, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Humans, Male, Methamphetamine/*poisoning, Mice, Mutation, Neuroscience letters, Neurotoxicity Syndromes/*etiology/*metabolism, Sex Factors, Structure-Activity Relationship, Substantia Nigra/drug effects/metabolism, Transgenic
Tags: *BMI percentile, *Body Mass Index, *infant growth, *obese, *weight for length, 2017, Age Factors, Bansal Danesh, Bliss Sherri, Body Mass Index, Bolling Christopher, Case Control Studies, Case-Control Studies, Child, Comparative Studies, Crimmins Nancy A, Daniels Stephen R, Evaluation Research, Female, Human, Humans, Incidence, Infant, Klein Jillian, Logistic Models, Logistic Regression, Male, Morbid – Diagnosis, Morbid – Epidemiology, Morbid/*diagnosis/*epidemiology, Multicenter Studies, Newborn, Obesity, Obesity – Diagnosis, Obesity – Epidemiology, Obesity/diagnosis/epidemiology, Predictive Value of Tests, Preschool, Reference Values, Reproducibility of Results, Risk Assessment, Scales, Sex Factors, Smego Allison, Suh Christina, The Journal of pediatrics, Validation Studies, Weight Gain, Woo Jessica G
Jaw-muscle architecture and mandibular morphology influence relative maximum jaw gapes in the sexually dimorphic Macaca fascicularis.
Tags: 2015, Animal/physiology, Animals, Articular/physiology, Behavior, Crab-eating macaques, Craniofacial morphology, Feeding Behavior/physiology, Female, Fossil primates, Functional morphology, Hylander William L, Jaw/*anatomy & histology/physiology, Joints/anatomy & histology/physiology, Journal of human evolution, Macaca fascicularis/*anatomy & histology/physiology, Male, Mandible/*anatomy & histology/physiology, Masticatory Muscles/*anatomy & histology/physiology, Physiologic cross-sectional area, Range of Motion, Sex Factors, Taylor Andrea B, Terhune Claire E, Vinyard Christopher J
Variation in hospital admission rates between a tertiary care and two freestanding emergency departments.
Tags: 2018, Admission rate, Ambulatory Care Facilities, Chi Square Test, Confidence Intervals, Dark Cedric, Department of Emergency Medicine, Emergency Service – Methods, Fisher's Exact Test, Freestanding emergency department, Human, Kovacs Mitch, Meek Craig A, Multiple Logistic Regression, NEOMED College of Medicine, Odds Ratio, Office Visits, Patient Admission, Patient Classification, Retrospective Design, Sex Factors, Shakya Sunita, Simon Erin L, T-Tests, Tertiary Health Care, The American journal of emergency medicine
Tags: 2016, Adolescence, Adolescent, Age Factors, Child, Department of Emergency Medicine, Emergency Service, Emergency Service – Statistics and Numerical Data, Female, Hayslip Dave, Hospital/*statistics & numerical data, Humans, Infant, Jouriles Nicholas, Kovacs Mitch, Male, NEOMED College of Medicine, Newborn, Preschool, Retrospective Design, Retrospective Studies, Severity of Illness Index, Severity of Illness Indices, Sex Factors, Simon Erin L, The American journal of emergency medicine, United States
Tags: *Needles, 2013, Adolescence, Adolescent, Adult, Anaphylaxis – Drug Therapy, Anaphylaxis/*drug therapy, Bhalla Mary Colleen, Body Mass Index, Cross Sectional Studies, Cross-Sectional Studies, Department of Emergency Medicine, Epinephrine – Administration and Dosage, Epinephrine/*administration & dosage, Equipment Design, Equipment Failure, Female, Frey Jennifer A, Gable Brad D, Human, Humans, Injections, Intramuscular – Equipment and Supplies, Intramuscular/instrumentation, Male, Middle Age, Middle Aged, Needles, NEOMED College of Medicine, Prospective Studies, Quadriceps Muscle/*anatomy & histology/diagnostic imaging, Quadriceps Muscles – Anatomy and Histology, Quadriceps Muscles – Ultrasonography, Reichenbach Matthew R, Sex Factors, Sympathomimetics – Administration and Dosage, Sympathomimetics/*administration & dosage, The American journal of emergency medicine, Ultrasonography, Wilber Scott T, Young Adult
Tags: 2017, 80 and over, Adult, Age Distribution, Age Factors, Aged, Aging, Barnholtz-Sloan Jill S, Blanda Rachel, Brain tumors, Centers for Disease Control and Prevention (U.S.)/statistics & numerical data, Central Nervous System Neoplasms/*epidemiology/*mortality, Female, Gittleman Haley, Glioma, Glioma/*epidemiology/*mortality, Humans, Incidence, Incidence-based mortality, Journal of neuro-oncology, Kromer Courtney, Kruchko Carol, Male, Middle Aged, Mortality, National Cancer Institute (U.S.)/statistics & numerical data, Ostrom Quinn T, Prevalence, Retrospective Studies, Russell Jeffrey, Sex Factors, Time trends, United States/epidemiology, Young Adult
Who do you think you are? Medical student socioeconomic status and intention to work in underserved areas.
Tags: *Career Choice, *Intention, *Medically Underserved Area, 2017, Adolescence, Adolescent, Advances in health sciences education : theory and practice, Attitude of Health Personnel, Career Planning and Development, Ethnic Groups, Female, Griffin Barbara, Hu Wendy, Humans, Intention, Male, Medical – Psychosocial Factors, Medical – Statistics and Numerical Data, Medical/*psychology/*statistics & numerical data, Medically Underserved Area, Medically underserviced areas, Porfeli Erik, Practice location intentions, Scales, Sex Factors, Social Class, Socioeconomic status, Students, Widening participation, Young Adult
Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system.
Tags: 2003, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Anderson L I, Animals, Dluzen D E, Dopamine/metabolism, Drug Interactions, Estrogens/metabolism/*pharmacology, Female, Gajjar T M, Journal of neural transmission (Vienna, Austria : 1996), Methamphetamine/antagonists & inhibitors/*toxicity, Mice, Neostriatum/*drug effects/metabolism/physiopathology, Neural Pathways/*drug effects/metabolism/physiopathology, Neuroprotective Agents/metabolism/pharmacology, Neurotoxins/antagonists & inhibitors/toxicity, Ovariectomy, Parkinson Disease/drug therapy/metabolism/physiopathology, Presynaptic Terminals/drug effects/metabolism, Reaction Time/drug effects/physiology, Sex Factors, Substantia Nigra/*drug effects/metabolism/physiopathology