Browse Items (9 total)
- Tags: Xu Jiesi
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Animals, Bile Acids and Salts/pharmacology/*therapeutic use, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet, G-Protein-Coupled/*agonists, Hep G2 Cells, High-Fat/adverse effects, Humans, Hypercholesterolemia/*drug therapy/etiology/metabolism, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Lee Yoon Kwang, Li Yuanyuan, Male, Mice, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*drug therapy/etiology/metabolism, Obesity/*drug therapy/etiology/metabolism, Receptors, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
Tags: *Postprandial Period, 2014, Acetylation/drug effects, Animals, ATP Citrate (pro-S)-Lyase/metabolism, Blood Glucose/*metabolism, Carboxylic Ester Hydrolases/*metabolism, Cheng Gang, Chromatin/metabolism, Department of Integrative Medical Sciences, Enzymologic/drug effects, Gene Expression Regulation, Glucose/*pharmacology, Histones/metabolism, Homeostasis, Inbred C57BL, Li Yuanyuan, Liver/*enzymology, Male, Mice, NEOMED College of Medicine, Nutritional Status, PloS one, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.
Tags: 2012, Adipose Tissue, Adiposity/genetics, Animals, Brown/pathology, Carcinoma/etiology/*genetics, Cell Transformation, Chen Wei-Dong, Cytoplasmic and Nuclear/*deficiency/genetics, Diet, Dietary Fats/metabolism, Edwards Peter A, Energy Metabolism/genetics, Female, Ge Xuemei, Gene Knockout Techniques, Glucose Intolerance/complications/genetics, Heemstra Lydia A, High-Fat/*adverse effects, Intestinal Absorption, Kasim Neda, Knockout, Leptin/deficiency/genetics, Liver Neoplasms/etiology/*genetics, Liver/pathology, Ma Huiyan, Male, Mice, Molecular endocrinology (Baltimore, Md.), Muscle, Neoplastic/genetics, Novak Colleen M, Obese, Obesity/*etiology/genetics, Receptors, Sex Factors, Skeletal/metabolism, Smith Joseph L, Weight Gain/genetics, Xu Jiesi, Zhang Yanqiao
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice.
A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism.
Tags: 2015, Animals, Apolipoproteins E/genetics, Atherosclerosis/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Experimental/genetics/metabolism, Hep G2 Cells, Hepatocyte Nuclear Factor 4/*genetics/metabolism, Humans, Knockout, LDL/genetics, Li Yuanyuan, Lipid Metabolism/*genetics, Lipoproteins/metabolism, Liver/metabolism, Mice, MicroRNAs/*genetics/metabolism, Middle Aged, Nature communications, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease/*genetics/metabolism, Physiological/*genetics, Receptors, Stress, Triglycerides/*metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR.
Tags: *Atherosclerosis, *Farnesoid X receptor, *NAFLD, *Obesity, *TGR5, 2018, Adorini Luciano, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Jadhav Kavita, Kasumov Takhar, Lee Yoon-Kwang, Li Yuanyuan, Molecular metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Xu Jiesi, Xu Yang, Xu Yanyong, Yin Liya, Zhang Yanqiao, Zhu Yingdong
Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.
Tags: *Intestinal Absorption, 2016, Adorini Luciano, Animals, Bile Acids and Salts/*chemistry, Biological Transport, Cholesterol/*metabolism, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Gonzalez Frank J, Hepatology (Baltimore, Md.), Inbred C57BL, Lee Yoon-Kwang, Li Fei, Mice, NEOMED College of Medicine, Receptors, Xu Jiesi, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.
Tags: *Homeostasis, *Lipid Metabolism, 2014, Adorini Luciano, Animals, Carboxylic Ester Hydrolases/*physiology, Chen Wei-Dong, Cholesterol/blood, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Fatty Acids/metabolism, Ge Xuemei, Hepatology (Baltimore, Md.), Inbred C57BL, Jadhav Kavita, Li Yuanyuan, Lipogenesis, Liver/*enzymology, Mice, NEOMED College of Medicine, Receptors, Sterol Regulatory Element Binding Protein 1/physiology, Triglycerides/metabolism, Xu Jiesi, Xu Yang, Yin Liya, Zhang Yanqiao