Browse Items · NEOMED Bibliography Database

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review).

Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), which has been reported to be important in the trafficking of cargo from the endoplasmic reticulum (ER) to the Golgi, and in…

Tags: *Disease Susceptibility, *Signal Transduction, 2018, Animals, Carrier Proteins/chemistry/genetics/*metabolism, Gene Expression Regulation, Humans, Hussein Nazar J, International journal of molecular medicine, Mbimba Thomas, Najeed Ayesha, Protein Binding, Protein Interaction Domains and Motifs, Protein Transport, Safadi Fayez F, Structure-Activity Relationship

On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.

The sterol 12alpha-hydroxylase (CYP8B1) is a key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid (CA) and chenodeoxycholic acid (CDCA). In similarity with cholesterol…

Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.

Oxysterol 7 alpha-hydroxylase catalyzes hydroxylation of oxysterols and neurosterols and plays a role in the alternative bile acid synthesis pathway. This gene is widely expressed in many organs and peripheral tissues and may protect tissues from the…

Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.

A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct was selected for studying transcriptional regulation of CYP7A gene promoter. Insulin and phorbol

Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.

Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor alpha (PPARalpha). The objective of this study was to investigate the…

Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation

Rat alpha(2)-macroglobulin inhibits NGF-promoted neurite outgrowth, TrK phosphorylation, and gene expression of pheochromocytoma PC12 cells.

Rat alpha-1-macroglobulin (alpha(1)M) and alpha-2-macroglobulin (alpha(2)M) are murine homologs of human alpha(2)M, and rat alpha(2)M is generally known as an acute-phase protein. Monoamine-activated forms of human alpha(2)M have been shown to…

Tags: 1999, Adrenal Gland Neoplasms/metabolism, alpha-Macroglobulins/*pharmacology, Animals, Gene Expression Regulation, Journal of neuroscience research, Koo P H, Lee P G, Neoplastic/*drug effects, Nerve Growth Factors/*antagonists & inhibitors, Neurites/*drug effects, PC12 Cells, Pheochromocytoma/metabolism, Phosphorylation, Proto-Oncogene Proteins c-jun/genetics, Rats, Receptor, Sprague-Dawley, trkA/*metabolism

Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s.

We have studied the activation of aflatoxin B1 by hamster liver microsomes and purified hamster cytochrome P-450 isozymes using a umu mutagen test. The hamster liver microsomes or S-9 fractions were much more active than rat liver microsomes or S-9…

Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).

The transcriptional regulation of the rat cholesterol 7 alpha-hydroxylase gene (CYP7) by hormones and signal transduction pathways was studied by transient transfection assay of the promoter activity. HepG2 cells were transfected with deletion…

Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.

Nucleotide sequences of a 7997-base pair SacI fragment spanning 3643 base pairs of the upstream promoter region to exon 4 of the rat cholesterol 7 alpha-hydroxylase gene (CYP7) have been determined. DNase I footprinting and electrophoretic mobility…

Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.

Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a…

Tags: 10-Dimethyl-1, 2-benzanthracene/toxicity, 2017, 9, Animal Studies, Animals, Anti-Inflammatory Agents/*pharmacology, anti-inflammatory effects, Anticarcinogenic Agents/pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms, breast tumor, Cell Transformation, Chemoprevention, COX-2, Cyclooxygenase 2/genetics/metabolism, DMBA, Dose-Response Relationship, Drug, Experimental/*prevention & control, Female, Gene Expression Regulation, HSP90, HSP90 Heat-Shock Proteins/genetics/metabolism, I-kappa B Kinase/genetics/metabolism, Inflammation Mediators, Mammary Neoplasms, Mandal Animesh, Neoplasms – Prevention and Control, Neoplastic, Neoplastic/drug effects, NF-E2-Related Factor 2/genetics/*metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, Nrf2, Nutrients, Physical Education and Training, Plant Preparations/*pharmacology, Pomegranate, Punica granatum, Punicaceae/*chemistry, Rats, Signal Transduction

Regulation of bile acid synthesis.

Bile acids are important physiological agents required for disposal of cholesterol and absorption of vitamins and fats. Bile acids are synthesized from cholesterol in the liver. Enterohepatic circulation of bile acids is very efficient and plays an…

Tags: 1998, Animals, Bile Acids and Salts/*biosynthesis, Chiang J Y, Cholestanetriol 26-Monooxygenase, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cholesterol/metabolism, Cytochrome P-450 Enzyme System/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, Frontiers in bioscience : a journal and virtual library, Gene Expression Regulation, Humans, Liver/metabolism, NEOMED College of Medicine, Steroid 12-alpha-Hydroxylase/metabolism, Steroid Hydroxylases/metabolism

Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China.

We previously analyzed human prostate tissue containing stroma near to tumor and from cancer-negative tissues of volunteers. Over 100 candidate gene expression differences were identified and used to develop a classifier that could detect nearby…

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.

The hepatocyte nuclear factor 4alpha (HNF4alpha) is a liver-enriched nuclear receptor that plays a critical role in early morphogenesis, fetal liver development, liver differentiation and metabolism. Human HNF4alpha gene mutations cause maturity…

Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Chiang John Y L, Department of Integrative Medical Sciences, Expert opinion on drug metabolism & toxicology, Gene Expression Regulation, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 4/genetics/*metabolism, Humans, Lipid Metabolism, Liver/metabolism, Mutation, NEOMED College of Medicine, Pharmaceutical Preparations/*metabolism, Signal Transduction/physiology

MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.

Metastatic melanoma is the most aggressive form of this cancer. It is important to understand factors that increase or decrease metastatic activity in order to more effectively research and implement treatments for melanoma. Increased cell invasion…

Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.

Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol…

Alterations in gene array patterns in dendritic cells from aged humans.

Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs decline with age.…

A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3'-untranslated region (3'-UTR). However, the…

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

The nature and role of periosteum in bone and cartilage regeneration.

This study was undertaken to determine whether periosteum from different bone sources in a donor results in the same formation of bone and cartilage. In this case, periosteum obtained from the cranium and mandible (examples of tissue supporting…

Establishing reliable miRNA-cancer association network based on text-mining method.

Associating microRNAs (miRNAs) with cancers is an important step of understanding the mechanisms of cancer pathogenesis and finding novel biomarkers for cancer therapies. In this study, we constructed a miRNA-cancer association network (miCancerna)…

Estrogen-related receptor gamma controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.

BACKGROUND: The hepatic endocannabinoid system and cytochrome P450 2E1 (CYP2E1), a key enzyme causing alcohol-induced reactive oxygen species (ROS) generation, are major contributors to the pathogenesis of alcoholic liver disease. The nuclear hormone…

Tags: 2013, Alcohol-Induced Injury, Alcoholic Liver Disease, Alcoholic/genetics/*metabolism/prevention & control, Animals, Cannabinoid, CB1/*physiology, Chiang John Y L, Choi Hueng-Sik, Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP2E1/genetics/*metabolism, Department of Integrative Medical Sciences, Enzyme Inhibitors/pharmacology/therapeutic use, Enzymologic/drug effects/physiology, Estrogen/deficiency/genetics/*physiology, Ethanol/pharmacology, Gene Expression Profiling/methods, Gene Expression Regulation, Gene Regulation, Genetic/physiology, Gut, Inbred C57BL, Jang Hyun-Hee, Jeong Won-Il, Kim Don-Kyu, Kim Jung Ran, Kim Yong-Hoon, Knockout, Koh Minseob, Koo Seung-Hoi, Lee Chul-Ho, Liver, Liver Diseases, Liver Metabolism, Liver/metabolism, Male, Mice, NEOMED College of Medicine, Oxidation-Reduction, Oxidative Stress/physiology, Park Jinyoung, Park Seung Bum, Park Tae-Sik, Receptor, Receptors, Signal Transduction/drug effects/physiology, Tamoxifen/analogs & derivatives/pharmacology/therapeutic use, Transcription, Yun Chul-Ho

Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.

Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme responsible for eliminating approximately 20% of marketed drugs. Studies have shown that differential transcriptional regulation of CYP2D6 may contribute to large interindividual…

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.

Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of…

Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis.

The endoplasmic reticulum is the site of synthesis and folding of secretory proteins and is sensitive to changes in the internal and external environment of the cell. Both physiological and pathological conditions may perturb the function of the…

Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan.

Among mammals, modern cetaceans (whales, dolphins, and porpoises) are unusual in the absence of hind limbs. However, cetacean embryos do initiate hind-limb bud development. In dolphins, the bud arrests and degenerates around the fifth gestational…

Tags: *Body Patterning, 2006, Animals, Bajpai S, Cell Polarity, Cohn M J, Department of Anatomy & Neurobiology, Developmental, Dolphins/*embryology/genetics/metabolism, Gene Expression Regulation, Heyning J, Hindlimb/cytology/*embryology/metabolism, Horton W E Jr, Limb Buds/cytology/embryology/metabolism, NEOMED College of Medicine, Phylogeny, Proceedings of the National Academy of Sciences of the United States of America, Stevens L S, Thewissen J G M

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis.

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there are no effective therapies. Patients with AH show impaired hepatocyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (LPS)…

Tags: 2016, Affo Silvia, Alcoholic/*immunology, Altamirano Jose, Animals, Arroyo Vicente, Bataller Ramon, Caballeria Juan, Cell Proliferation, Cells, Chen Jiegen, Collagen/genetics/metabolism, Common/*pathology, Crews Fulton, Cultured, Department of Pharmaceutical Sciences, Dumitru Raluca, Female, Gene Expression Profiling, Gene Expression Regulation, Gines Pere, Hepatic Duct, Hepatitis, Hepatocytes/*metabolism/pathology, Humans, Inbred BALB C, Keratins, Knockout, Lipopolysaccharides/metabolism, Lozano Juan Jose, Male, Matsushita Hiroshi, Mice, Middle Aged, Morales-Ibanez Oriol, NEOMED College of Pharmacy, Odena Gemma, Rautou Pierre-Emmanuel, Rodrigo-Torres Daniel, Sancho-Bru Pau, Scientific reports, Seki Ekihiro, Signal Transduction, Toll-Like Receptor 4/genetics/*metabolism, Type I/genetics/*metabolism, Valla Dominique, You Min, Zou Jian

Interleukin-1beta induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes.

Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in

Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.

The liver is a major organ that controls hepatic and systemic homeostasis. Dysregulation of liver metabolism may cause liver injury. Previous studies have demonstrated that carboxylesterase 1 (CES1) regulates hepatic triglyceride metabolism and…

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.

Tumor vessels are characterized by abnormal morphology and hyperpermeability that together cause inefficient delivery of chemotherapeutic agents. Although vascular endothelial growth factor has been established as a critical regulator of tumor…

miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes.

IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of MCPIP1 mRNA harbors a miR-139…

Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan derivatives.

Several methylated derivatives of a plant lignan, nordihydroguaiaretic acid (NDGA) were found to be potent anti-viral agents by suppressing Sp1 regulated transcription within the sexually transmitted viruses human immunodeficiency virus (HIV) and…

Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms.

Multiple isoforms of the contractile protein myosin are present in mammalian skeletal muscles. The diversity of the heavy-chain subunits of myosin (MyHCs) in intrafusal fibers is thought to reflect a pathway of differentiation that is unique to…

Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and…

Tags: *Ceruloplasmin, *Deamidation, *Heavy water metabolic labeling, *High resolution mass spectrometry, *Iron metabolism, *LC-MS/MS, *Non-enzymatic glycation, *Oxidative Stress, *Protein Processing, *Proteome dynamics, *Serotransferrin, *Type 2 diabetes mellitus, 2017, Adult, Amino Acid Sequence, Bena James, Case-Control Studies, Ceruloplasmin/genetics/*metabolism, Department of Pharmaceutical Sciences, Deuterium/metabolism, Diabetes Mellitus, Diabetic, Diet, Female, Free radical biology & medicine, Gene Expression Regulation, Glycated Hemoglobin A/genetics/metabolism, Glycosylation, Golizeh Makan, Humans, Ilchenko Serguei, Iron/*metabolism, Isotope Labeling, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Male, Middle Aged, NEOMED College of Pharmacy, Osme Abdullah, Oxidation-Reduction, Oxidative Stress, Post-Translational, Proteolysis, Sadygov Rovshan G, Transferrin/genetics/*metabolism, Type 2/diet therapy/genetics/*metabolism/pathology

Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.

Due to the existence of cancer stem cells (CSCs), persistence and relapse of human hepatocellular carcinoma (HCC) are common after treatment with existing anti-cancer therapies. Emerging evidence indicates that lipopolysaccharide (LPS) plays a…

Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.

The cytochrome P450 gene 4 family (CYP4) consists of a group of over 63 members that omega-hydroxylate the terminal carbon of fatty acids. In mammals, six subfamilies have been identified and three of these subfamily members show a preference in the…

Tags: *Cytochrome P-450 Enzyme System/genetics/metabolism/physiology, 2008, Animals, Biochemical pharmacology, Cytochrome P-450 CYP4A/genetics/metabolism/physiology, Department of Integrative Medical Sciences, Enzymologic, Fatty Acids/*metabolism, Gene Expression Regulation, Hardwick James P, Humans, Metabolic Diseases/enzymology/*metabolism, NEOMED College of Medicine

Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.

The conversion of cholesterol to bile acids is the major pathway for cholesterol catabolism. Bile acids are metabolic regulators of triglycerides and glucose metabolism in the liver. This study investigated the roles of FoxO1 in the regulation of…

Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor

Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.

The human CYP4F2 gene encodes a LTB4 omega-hydroxylase P450 prominently expressed in liver and kidney that functions to metabolize and inactivate the pro-inflammatory eicosanoids, LTB4 and arachidonic acid. HepG2 cells transfected with CYP4F2 -506/-6…

Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.

Multimeric AUUUA elements in an AU-rich 3'-untranslated region (3'-UTR) have been shown to confer message instability to numerous ephemeral transcripts through the formation of RNA-protein complexes. We show here that the 3'-UTR of VIP mRNA, which…

Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.

The expression of cholesterol 7 alpha-hydroxylase mRNA levels in confluent HepG2 cultures was reduced by tauro- or glyco-conjugates of deoxycholate and chenodeoxycholate, but not by cholate. Ursodeoxycholates, on the other hand, stimulated the mRNA…

Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.

Nearly 60% of patients with head and neck squamous cell carcinoma (HNSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell migration and invasion, which are in part dependent on extracellular matrix degradation by…

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