Browse Items (23 total)
- Tags: The Journal of biological chemistry
Defining α-synuclein species responsible for Parkinson disease phenotypes in mice
Tags: 2019, alpha-synuclein (a-synuclein), amyloid, Anabtawi Nadia M, Camino José D, Castellana-Cruz Marta, Chen Serene W, Cremades Nunilo, cytotoxicity, Department of Pharmaceutical Sciences, Dobson Christopher M, fibril, Fleming Sheila, Freire Jennifer, Froula Jessica M, June 2019 Update, Kumita Janet R, Lewy Body, motor behavior defect, NEOMED College of Pharmacy, neurodegenerative disease, oligomer, Parkinson Disease, Protein Aggregation, The Journal of biological chemistry, Thrasher Drake R, Volpicelli-Daley Laura A, Yazdi Allen A
Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, *Receptors, 1997, Animals, Chiang J Y, Chickens, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Circadian Rhythm, COUP Transcription Factor I, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Electrophoresis, Enzymologic, Genetic, Glucocorticoid/*genetics, Models, Molecular, NEOMED College of Medicine, Nuclear Proteins/*metabolism, Polyacrylamide Gel, Promoter Regions, Rats, Receptors, Recombinant Proteins/genetics/metabolism, Retinoic Acid/*metabolism, Retinoid X Receptors, Steroid, Stroup D, The Journal of biological chemistry, Transcription Factors/*metabolism
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.
Tags: *Gene Expression Regulation, 1990, Amino Acid Sequence, Animals, Base Sequence, Cell Fractionation, Centrifugation, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics/immunology, Cholestyramine Resin/pharmacology, Circadian Rhythm, Cloning, Cytochrome P-450 Enzyme System/genetics, Density Gradient, Department of Integrative Medical Sciences, DNA/genetics/isolation & purification, Enzyme Induction, Enzymologic, Epitopes/analysis, Female, Immunoblotting, Inbred Strains, Kinetics, Li Y C, Liver/drug effects/*enzymology, Messenger/*genetics, Molecular Sequence Data, Molecular/methods, NEOMED College of Medicine, Nucleic Acid, Polyribosomes/metabolism/ultrastructure, Rats, Restriction Mapping, RNA, Sequence Homology, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Wang D P
The expression of a catalytically active cholesterol 7 alpha-hydroxylase cytochrome P450 in Escherichia coli.
Tags: 1991, Amino Acid Sequence, Base Sequence, Blotting, Catalysis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cholesterol/metabolism, Chromatography, Codon, Department of Integrative Medical Sciences, DNA/genetics, Electrophoresis, Escherichia coli/*enzymology, Gene Expression, Li Y C, Liquid, Liver/enzymology, Microsomes, Molecular Sequence Data, NEOMED College of Medicine, Plasmids, Polyacrylamide Gel, Polymerase Chain Reaction, Substrate Specificity, The Journal of biological chemistry, Western
Monoamine-activated alpha 2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction.
Tags: 1994, Adrenal Gland Neoplasms, alpha-Macroglobulins/isolation & purification/*metabolism/pharmacology, Animals, ErbB Receptors/isolation & purification/metabolism, Fibrinolysin/metabolism, Humans, Koo P H, Male, Mice, Mitogen-Activated Protein Kinase 1, Nerve Growth Factor/drug effects/isolation & purification/*metabolism, Nerve Growth Factors/*pharmacology, Neurites/drug effects/*physiology, PC12 Cells, Pheochromocytoma, Phosphorylation, Platelet-Derived Growth Factor/isolation & purification/metabolism, Protein-Serine-Threonine Kinases/metabolism, Protein-Tyrosine Kinases/metabolism, Proto-Oncogene Proteins/drug effects/isolation & purification/*metabolism, Qiu W S, Receptor, Receptor Protein-Tyrosine Kinases/drug effects/isolation & purification/*metabolism, Receptors, Serotonin/*metabolism/pharmacology, Signal Transduction/drug effects/*physiology, The Journal of biological chemistry, trkA
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.
Tags: *Circadian Rhythm, 1990, Animals, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/isolation & purification/metabolism, Cholestyramine Resin/*pharmacology, Chromatography, Department of Integrative Medical Sciences, Durapatite, Enzyme Induction, Hydroxyapatites, Inbred Strains, Ion Exchange, Isoenzymes/*biosynthesis/isolation & purification, Kinetics, Lin G M, Liver/drug effects/*enzymology, Microsomes, Miller W F, NEOMED College of Medicine, Obesity/enzymology, Organ Specificity, Polyethylene Glycols, Rats, Steroid Hydroxylases/*biosynthesis, The Journal of biological chemistry, Zucker
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
Tags: *Promoter Regions, 1994, Animals, Antigens, Base Sequence, Bile Acids and Salts/*metabolism, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cloning, Deoxyribonuclease I, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/metabolism, Oligodeoxyribonucleotides, Polyomavirus Transforming/genetics, Rats, Recombinant Fusion Proteins/genetics/metabolism, Sprague-Dawley, Stroup D, The Journal of biological chemistry, Thyroid Hormones/genetics
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *Transcription, 2000, Animals, Bile Acids and Salts/*pharmacology, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear, Department of Integrative Medical Sciences, DNA-Binding Proteins/*physiology, Genetic, Humans, Kimmel R, NEOMED College of Medicine, Promoter Regions, Receptors, Repressor Proteins/*physiology, Response Elements, Retinoic Acid/genetics, Retinoid X Receptors, Stroup D, The Journal of biological chemistry, Transcription Factors/genetics/*physiology, Tumor Cells, Weinberger C
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Tags: *Gene Expression Regulation, *Transcriptional Activation, 2006, Adolescent, Adult, Animals, Chiang John Y L, Child, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzymologic, Female, Forkhead Box Protein O1, Forkhead Transcription Factors/*physiology, Hepatocytes/*enzymology, Humans, Insulin/metabolism/*physiology, Kong Xiaoying, Li Tiangang, Male, Middle Aged, NEOMED College of Medicine, Owsley Erika, Preschool, Rats, Sterol Regulatory Element Binding Protein 1/*physiology, Strom Stephen, The Journal of biological chemistry, Transcription Factors/*physiology
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
Tags: *Gene Expression Regulation, 2005, Adenoviridae/genetics, Animals, Apoptosis, beta-Galactosidase/metabolism, Blotting, Butadienes/pharmacology, Caspase Inhibitors, Cell Differentiation, Cell Line, Chondrocytes/*metabolism, Collagen Type II/metabolism, Department of Anatomy & Neurobiology, Down-Regulation, Enzyme Inhibitors/pharmacology, Fibroblasts/metabolism, Fluorescence, Genetic, High Mobility Group Proteins/*metabolism, Horton Walter E Jr, Lac Operon, Luciferases/metabolism, MAP Kinase Kinase Kinases/*metabolism, McBurney Denise, Messenger/metabolism, Microscopy, Mitogen-Activated Protein Kinase 1/*metabolism, Mitogen-Activated Protein Kinase 3/*metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Nitriles/pharmacology, Phenotype, Phosphorylation, Promoter Regions, Protein Kinase C-alpha, Protein Kinase C/antagonists & inhibitors, Proteoglycans/metabolism, Proto-Oncogene Proteins c-bcl-2/*metabolism, Rats, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transduction, Small Interfering/metabolism, SOX9 Transcription Factor, Sprague-Dawley, The Journal of biological chemistry, Time Factors, Transcription, Transcription Factors/*metabolism, Transfection, Western, Yagi Rieko
Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis.
Tags: 2005, Animals, Annexin A5/metabolism, Anti-Bacterial Agents/metabolism, Apoptosis/*physiology, Biomarkers, Carlson Sara G, Caspase 12, Caspases/metabolism, CCAAT-Enhancer-Binding Proteins/metabolism, Cell Differentiation/*physiology, Cells, Chondrocytes/cytology/*physiology, Collagen Type II/metabolism, Cultured, Department of Anatomy & Neurobiology, DNA Fragmentation, Endoplasmic Reticulum/*metabolism, Extracellular Matrix/metabolism, Gene Expression Regulation, Glucose/metabolism, Horton Walter E Jr, McBurney Denise, NEOMED College of Medicine, Proliferating Cell Nuclear Antigen/metabolism, Rats, Signal Transduction/*physiology, Thapsigargin/metabolism, The Journal of biological chemistry, Transcription Factor CHOP, Transcription Factors/metabolism, Tunicamycin/metabolism, Yang Ling
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Tags: *bile acid, *bile acid metabolism, *FXR, *Gene Expression Regulation, *GLP-1, *Lipid Metabolism, *liver metabolism, *Non-alcoholic Fatty Liver Disease, *Obesity, *TGR5, *type 2 diabetes, 2017, Animals, Bile Acids and Salts/*biosynthesis/genetics, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Dietary Fats, G-Protein-Coupled/genetics/*metabolism, Glucagon-Like Peptide 1/genetics/metabolism, Glucose/metabolism, Gonzalez Frank, Knockout, Krausz Kristopher W, Lipid Metabolism, Liu Hailiang, Liver/*metabolism, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism/pathology, Pathak Preeti, Receptors, The Journal of biological chemistry, Xie Cen
MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
Tags: *adiponectin, *alcohol, *intestine, *iron, *liver injury, *Signal Transduction, 2016, Adiponectin/genetics/*metabolism, Alcoholic/genetics/*metabolism/pathology, Animals, Department of Pharmaceutical Sciences, Fatty Liver, Fibroblast Growth Factors/genetics/*metabolism, Han Yoonhee, Hu Xudong, Humans, Iron-Binding Proteins/metabolism, Jogasuria Alvin, Kim Chunki, Knockout, Male, Membrane Proteins/*deficiency/metabolism, Mice, NEOMED College of Pharmacy, NF-kappa B/genetics/metabolism, Shen Hong, Sirtuin 1/genetics/metabolism, The Journal of biological chemistry, Wang Jiayou, Wu Jiashin, You Min
Mutation in Osteoactivin Promotes Receptor Activator of NFkappaB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.
Tags: *Mutation, 2015, Abdelmagid Samir M, Akt, Animals, Belcher Joyce Y, Bone, bone marrow, Bone Remodeling, Cell Differentiation/*physiology, Cell Survival/*physiology, Department of Anatomy & Neurobiology, Eye Proteins/*genetics, Hankenson Kurt D, Inbred DBA, Khol Matthew, Malcuit Christopher, MAP kinases (MAPKs), Mbimba Thomas, Membrane Glycoproteins/*genetics, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, OSTEOACTIVIN, osteoclast, Osteoclasts/*cytology, osteopetrosis, RANK Ligand/metabolism/*physiology, Safadi Fayez F, Signal Transduction, Sondag Gregory R, Stinnett Hilary, The Journal of biological chemistry, X-Ray Microtomography, Yu Bing
Generation and characterization of ATP analog-specific protein kinase Cdelta.
Tags: 2015, Adenosine Triphosphate/*analogs & derivatives/*chemistry, Amino Acid, Amino Acid Sequence, Animals, ATP, Catalysis, Cercopithecus aethiops, Chemical Biology, Chou Wen-Hai, COS Cells, Geldenhuys Werner J, Glutamine/chemistry, Han Xiqian, Humans, Inbred C57BL, Kumar Varun, Leucine/chemistry, Lysine/chemistry, Messing Robert O, Mice, Molecular Sequence Data, Neutrophils/metabolism, Phenylalanine/chemistry, Phosphorylation, Protein Binding, Protein Kinase C (PKC), Protein Kinase C-delta/*metabolism, Protein Phosphorylation, Purines/chemistry, Sequence Homology, Signal Transduction, stroke, Substrate Specificity, Superoxides/chemistry, The Journal of biological chemistry, Transgenic, Wang Dan, Weng Yi-Chinn
Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.
Tags: *DNA methylation, *Epigenesis, 2014, 5-hmC, 5-Methylcytosine/analogs & derivatives, Chondrocytes, Chondrocytes/chemistry/*metabolism, Cytokine, Cytosine/*analogs & derivatives/analysis/metabolism, Department of Anatomy & Neurobiology, Dioxygenase, DNA Methylation, DNA-Binding Proteins/*biosynthesis/genetics, Epigenetics, Genetic, Haqqi Tariq M, Haseeb Abdul, Humans, IL-1, Interleukin-1beta/pharmacology/*physiology, Isocitrate Dehydrogenase/*biosynthesis/genetics, Ketoglutaric Acids/*metabolism, Makki Mohammad Shahidul, Messenger/biosynthesis/genetics, Mixed Function Oxygenases, NEOMED College of Medicine, Primary Cell Culture, Proto-Oncogene Proteins/*biosynthesis/genetics, RNA, The Journal of biological chemistry, TNF-alpha, Tumor Necrosis Factor-alpha/pharmacology/physiology
Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis.
Tags: 2013, Animals, Bile Acids and Salts/*biosynthesis, Chiang John Y L, Cholesterol, Cholesterol/*biosynthesis/genetics, Circadian Rhythm/*physiology, Department of Integrative Medical Sciences, Diabetes, Diabetes Mellitus, Enzyme Induction/physiology, Fasting/*metabolism, Fatty Liver/drug therapy/genetics/metabolism/pathology, Group F, Hep G2 Cells, Humans, Li Tiangang, Lipid Metabolism, Member 1/genetics/*metabolism, Mice, NEOMED College of Medicine, Non-alcoholic Fatty Liver Disease, Nuclear Receptor Subfamily 1, Nuclear Receptors, Obesity, Pathak Preeti, Phosphorylation/physiology, Protein Kinases/genetics/metabolism, Response Elements/physiology, Steroid 12-alpha-Hydroxylase/*biosynthesis/genetics, The Journal of biological chemistry, Type 2/drug therapy/genetics/metabolism/pathology
An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1.
Tags: *Repetitive Sequences, 2002, Alanine/metabolism, Amino Acid, Amino Acid Sequence, Animals, Arginine/metabolism, Base Sequence, Cell Compartmentation, Cercopithecus aethiops, DNA Primers, Fluorescent Antibody Technique, Indirect, Ligands, Mao Hanwen, Molecular Sequence Data, Phosphoprotein Phosphatases/*metabolism, Proline/metabolism, Protein Phosphatase 1, Recombinant Proteins/chemistry/metabolism, Rosenthal Kenneth S, Subcellular Fractions/metabolism, The Journal of biological chemistry, Threonine/metabolism, Vero Cells, Viral Proteins/chemistry/*metabolism
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Tags: *Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Dietary Fats/administration & dosage/adverse effects, Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/genetics, Glucose/*metabolism/pharmacology, Insulin/*metabolism, Klaassen Curtis D, Li Tiangang, Mice, NEOMED College of Medicine, Obesity/etiology/genetics/*metabolism, Ochoa Adrian, Postprandial Period/genetics, Receptors, Sweetening Agents/pharmacology, The Journal of biological chemistry, Transgenic, Zhang Youcai
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
Tags: 2010, Absorption, Anderson Jody, Animals, Biological, Cell Line, Cholesterol/*metabolism, Class B/*genetics/metabolism, Coronary Disease/metabolism, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Edwards Peter A, Glucose/metabolism, Gonzalez Frank J, Hepatocyte Nuclear Factor 4/metabolism, Homeostasis, Humans, Lipoproteins/metabolism, Liver/metabolism, Ma Huiyan, Mice, Models, NEOMED College of Medicine, Receptors, Scavenger Receptors, The Journal of biological chemistry, Willson Timothy M, Yin Liya, Zhang Yanqiao
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
Tags: *DNA-Binding Proteins, *Transcription, 2001, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics, Cytoplasmic and Nuclear/physiology, Department of Integrative Medical Sciences, Genetic, Genetic/physiology, Hepatocyte Nuclear Factor 4, Humans, Molecular Sequence Data, NEOMED College of Medicine, Phosphoproteins/*physiology, Promoter Regions, Receptors, Repressor Proteins/*pharmacology, Steroid 12-alpha-Hydroxylase, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Transcription Factors/*physiology, Tumor Cells, Zhang M
Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.
Tags: *Intracellular Signaling Peptides and Proteins, 2001, Amyloid beta-Peptides/*biosynthesis/metabolism, Apoptosis Regulatory Proteins, Apoptosis/*physiology, Carrier Proteins/genetics/*physiology, Caspases/*metabolism, Chang X, Cultured, Du H, Enzyme Activation, Guo Q, Humans, Kinetics, Leucine Zippers, Neuroblastoma, Peptide Fragments/*biosynthesis/metabolism, Recombinant Proteins/metabolism, The Journal of biological chemistry, Time Factors, Transfection, Tumor Cells, Xie J