Browse Items (14 total)
- Tags: Enzymologic
Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.
Tags: 2001, Base Sequence, Binding, Binding Sites/genetics, Cell Line, Chiang J Y, Competitive, CpG Islands/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA/genetics, Enzymologic, gene, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics/metabolism, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid/genetics, Protein Binding, Recombinant Fusion Proteins/genetics/metabolism, Regulatory Sequences, Sequence Deletion, Site-Directed, Sp1 Transcription Factor/metabolism/*physiology, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Tumor Cells, Wu Z
Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A).
Tags: *Gene Expression Regulation, *Receptors, 1997, Animals, Chiang J Y, Chickens, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Circadian Rhythm, COUP Transcription Factor I, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/*metabolism, Electrophoresis, Enzymologic, Genetic, Glucocorticoid/*genetics, Models, Molecular, NEOMED College of Medicine, Nuclear Proteins/*metabolism, Polyacrylamide Gel, Promoter Regions, Rats, Receptors, Recombinant Proteins/genetics/metabolism, Retinoic Acid/*metabolism, Retinoid X Receptors, Steroid, Stroup D, The Journal of biological chemistry, Transcription Factors/*metabolism
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.
Tags: *Gene Expression Regulation, 1990, Amino Acid Sequence, Animals, Base Sequence, Cell Fractionation, Centrifugation, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics/immunology, Cholestyramine Resin/pharmacology, Circadian Rhythm, Cloning, Cytochrome P-450 Enzyme System/genetics, Density Gradient, Department of Integrative Medical Sciences, DNA/genetics/isolation & purification, Enzyme Induction, Enzymologic, Epitopes/analysis, Female, Immunoblotting, Inbred Strains, Kinetics, Li Y C, Liver/drug effects/*enzymology, Messenger/*genetics, Molecular Sequence Data, Molecular/methods, NEOMED College of Medicine, Nucleic Acid, Polyribosomes/metabolism/ultrastructure, Rats, Restriction Mapping, RNA, Sequence Homology, Steroid Hydroxylases/*genetics, The Journal of biological chemistry, Wang D P
Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s.
Tags: 1990, Aflatoxin B1, Aflatoxins/immunology/*metabolism, Animals, Antibodies/immunology, Chiang J Y, Cricetinae, Cytochrome P-450 Enzyme System/biosynthesis/isolation & purification/*metabolism, Department of Integrative Medical Sciences, Enzyme Induction/drug effects, Enzymologic, Gene Expression Regulation, Inbred Strains, Journal of biochemical toxicology, Lai T S, Liver/drug effects/*enzymology, Liver/enzymology, Mesocricetus, Methylcholanthrene/*pharmacology, Microsomes, Mutagenicity Tests, NEOMED College of Medicine, Rats, Salmonella typhimurium/enzymology/genetics, Subcellular Fractions/drug effects/enzymology
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
Tags: *Promoter Regions, 1994, Animals, Antigens, Base Sequence, Bile Acids and Salts/*metabolism, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cloning, Deoxyribonuclease I, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/metabolism, Oligodeoxyribonucleotides, Polyomavirus Transforming/genetics, Rats, Recombinant Fusion Proteins/genetics/metabolism, Sprague-Dawley, Stroup D, The Journal of biological chemistry, Thyroid Hormones/genetics
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Tags: *Gene Expression Regulation, 2008, Animals, Cell Line, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic, Forkhead Transcription Factors/physiology, Humans, Insulin/*physiology, Journal of lipid research, Li Tiangang, Ma Huiyan, Male, NEOMED College of Medicine, Nerve Tissue Proteins/physiology, Rats, Signal Transduction, Smad3 Protein/antagonists & inhibitors/pharmacology, Sprague-Dawley, Transforming Growth Factor beta1/*physiology, Tumor, Tumor Necrosis Factor-alpha/*physiology
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Tags: *Gene Expression Regulation, *Transcriptional Activation, 2006, Adolescent, Adult, Animals, Chiang John Y L, Child, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzymologic, Female, Forkhead Box Protein O1, Forkhead Transcription Factors/*physiology, Hepatocytes/*enzymology, Humans, Insulin/metabolism/*physiology, Kong Xiaoying, Li Tiangang, Male, Middle Aged, NEOMED College of Medicine, Owsley Erika, Preschool, Rats, Sterol Regulatory Element Binding Protein 1/*physiology, Strom Stephen, The Journal of biological chemistry, Transcription Factors/*physiology
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
Tags: *Gene Expression Regulation, 2006, Aged, Amino Acid Motifs, Bile Acids and Salts/metabolism, Cell Line, Cell Nucleus/metabolism, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*chemistry/*genetics, Cultured/metabolism, Department of Integrative Medical Sciences, Enzymologic, Female, Genes, Genetic, Gluconeogenesis, Glutathione Transferase/metabolism, Hepatocyte Nuclear Factor 4/metabolism/*physiology, Hepatocytes/metabolism, Homeodomain Proteins/metabolism/*physiology, Humans, Immunoprecipitation, Li Tiangang, Liver/metabolism, Luciferases/metabolism, Male, Messenger/metabolism, Middle Aged, NEOMED College of Medicine, Phosphoenolpyruvate Carboxykinase (ATP)/metabolism, Plasmids/metabolism, Protein Structure, Reporter, Response Elements, Reverse Transcriptase Polymerase Chain Reaction, RNA, Small Interfering/metabolism, Song Kwang-Hoon, Tertiary, The Journal of biological chemistry, Time Factors, Transcription, Transcriptional Activation, Transfection, Tumor Suppressor Proteins, Two-Hybrid System Techniques
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Tags: *Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Dietary Fats/administration & dosage/adverse effects, Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/genetics, Glucose/*metabolism/pharmacology, Insulin/*metabolism, Klaassen Curtis D, Li Tiangang, Mice, NEOMED College of Medicine, Obesity/etiology/genetics/*metabolism, Ochoa Adrian, Postprandial Period/genetics, Receptors, Sweetening Agents/pharmacology, The Journal of biological chemistry, Transgenic, Zhang Youcai
Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases.
Tags: *Cytochrome P-450 Enzyme System/genetics/metabolism/physiology, 2008, Animals, Biochemical pharmacology, Cytochrome P-450 CYP4A/genetics/metabolism/physiology, Department of Integrative Medical Sciences, Enzymologic, Fatty Acids/*metabolism, Gene Expression Regulation, Hardwick James P, Humans, Metabolic Diseases/enzymology/*metabolism, NEOMED College of Medicine
Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.
Tags: *Gene Expression Regulation, *Promoter Regions, 2000, Amino Acid Sequence, Archives of biochemistry and biophysics, Base Sequence, Cell Line, Chen L, Cloning, Cytochrome P-450 CYP4A, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 4, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, DNA, DNA Footprinting, Enzymologic, Exons, Genes, Genetic, Genetic/drug effects, Hardwick J P, Humans, Introns, Leukotriene B4/metabolism, Mixed Function Oxygenases/metabolism, Models, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Peroxisome Proliferators/*metabolism, Receptors, Reporter, Retinoic Acid Receptor alpha, Retinoic Acid/metabolism, Sequence Analysis, Transcription, Transcription Factors/metabolism, Transfection, Tretinoin/*metabolism, Zhang X
Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.
Tags: *Cell Movement, 2018, Arosarena Oneida A, Barr Eric W, Carcinoma, Cell Line, cell lines, Department of Anatomy & Neurobiology, Enzymologic, Extracellular Matrix, Gene Expression Regulation, Head and Neck Neoplasms/*enzymology/genetics/pathology, Human, Humans, Journal of cellular physiology, matrix metalloproteinases, Membrane Glycoproteins/genetics/*metabolism, Messenger/genetics/metabolism, NEOMED College of Medicine, neoplasm invasion, Neoplasm Invasiveness, Neoplastic, RNA, RNA Interference, Safadi Fayez F, Secreted/genetics/*metabolism, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/*enzymology/genetics/pathology, Tarr Joseph T, Thorpe Ryan, Transfection, Tumor, Yankey Hilary