Browse Items · NEOMED Bibliography Database

Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.

We have studied the immunochemical properties of two major 3-methylcholanthrene inducible hamster liver cytochrome P450 isozymes, P450 MC1 and P450 MC4. Immunoblots using specific antibodies against P450 MC1 and P450 MC4 demonstrated that these two…

Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s.

We have studied the activation of aflatoxin B1 by hamster liver microsomes and purified hamster cytochrome P-450 isozymes using a umu mutagen test. The hamster liver microsomes or S-9 fractions were much more active than rat liver microsomes or S-9…

Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.

Light (LM), transmission (TEM), and scanning (SEM) electron microscopy were used to characterize morphological changes induced in the gallbladder epithelium of female Syrian hamsters in response to one-month estradiol alone (E) and estradiol with…

Tags: 1995, Animals, Body Weight, Cricetinae, Electron, Epithelium/drug effects/ultrastructure, Estradiol/*toxicity, Female, Gallbladder/*drug effects/metabolism/ultrastructure, Gilloteaux J, Journal of submicroscopic cytology and pathology, Karkare S, Kelly T R, Lipids/blood, Medroxyprogesterone/*toxicity, Mesocricetus, Microscopy, Organ Size, Scanning

Gallstones induced by sex steroids in the female Syrian hamster: duration effects.

Scanning (SEM), and transmission (TEM) electron microscopy were used and correlated to morphologically characterize changes induced in the gallbladder epithelium of female Syrian hamster in response to treatments with estradiol (E) alone, and…

Tags: 1995, Animals, Body Weight, Cholelithiasis/*chemically induced, Cricetinae, Electron, Epithelium/drug effects/ultrastructure, Estradiol/*toxicity, Female, Gallbladder/*drug effects/pathology, Gilloteaux J, Journal of submicroscopic cytology and pathology, Karkare S, Lipids/blood, Medroxyprogesterone/*toxicity, Mesocricetus, Microscopy, Organ Size, Time Factors

Effects of sex steroids on the Syrian hamster liver.

The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it…

Tags: 1995, Adamiec-Beyga E, Animals, Biliary Tract/pathology, Cholelithiasis/*chemistry/pathology, Cricetinae, Electron, Estrogens/toxicity, Female, Gallbladder/pathology, Gilloteaux J, Gonadal Steroid Hormones/*toxicity, Histology and histopathology, Karkare S, Liver/*drug effects/pathology/ultrastructure, Medroxyprogesterone/pharmacology, Mesocricetus, Microscopy, Progesterone Congeners/pharmacology

Ultrastructural immunolocalization of the atrial natriuretic factor pathways in fetal, neonatal, and adult Syrian hamsters: from the atrial cardiomyocytes to the circulation via the endocardium, atrial capillaries and epicardium.

Atrial natriuretic factor (ANF)-immunoreactivity was identified with peroxidase-antiperoxidase staining and immunoelectron microscopic gold labeling techniques in atrial tissues of fetal, newborn and adult Syrian hamsters.

Tags: 1991, Aging/*metabolism, Animals, Atrial Natriuretic Factor/*metabolism, Capillaries/cytology/metabolism/ultrastructure, Cricetinae, Endocardium/cytology/metabolism/ultrastructure, Endothelium, Gilloteaux J, Immunoelectron, Jennes L, Journal of submicroscopic cytology and pathology, Menu R, Mesocricetus, Microscopy, Myocardium/metabolism/*ultrastructure, Newborn/*metabolism, Vanderhaeghen J J, Vascular/cytology/metabolism/ultrastructure

Ultrastructural aspects of atrium development: demonstration of endocardial discontinuities and immunolabeling of atrial natriuretic factor in the Syrian hamster.

The endocardium ultrastructure of 13 embryonic day old hamsters was examined, especially in relationship with the atrial myocytes. The endothelial morphology was described, including the junctional attachments and their relationships with subjacent…

Tags: 1989, Anatomy and embryology, Animals, Atrial Natriuretic Factor/*analysis, Cricetinae, Electron, Endocardium/analysis/*embryology/ultrastructure, Endothelium/analysis/embryology/ultrastructure, Gilloteaux J, Heart Atria/analysis/embryology/ultrastructure, Immunohistochemistry, Microscopy

Transplacental cardiotoxicity of cocaine: atrial damage following treatment in early pregnancy.

Using light, transmission (TEM) and scanning (SEM) electron microscopy, cocaine-induced defects were observed in hamster atria. Compared with controls, the treated atria from neonates show endocardial and myocardial damages as the atrial walls…

Tags: 1991, Animals, Cocaine/*toxicity, Congenital/chemically induced/*pathology, Cricetinae, Dalbec J P, Electron, Endocardium/ultrastructure, Female, Gilloteaux J, Heart Atria/*ultrastructure, Heart Defects, Maternal-Fetal Exchange, Mesocricetus, Microscopy, Pregnancy, Random Allocation, Scanning, Scanning microscopy

Sex steroid induction of gallstones in the male Syrian hamster.

Light (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques were used to characterize morphologic changes induced in the gallbladder of Syrian hamsters following a one-month estradiol (E) and estradiol + medroxyprogesterone…

Light and electron microscopical immunolocalization of neuropeptide Y-containing nerves in the hamster gallbladder.

Neuropeptide Y (NPY)-containing nerve structures were detected in the Syrian hamster gallbladder by using peroxidase-antiperoxidase immunohistochemical staining and immunoelectron microscopic techniques. In addition, Alcian blue-P.A.S. was used to…

Epithelial surface changes and induction of gallstones in the male Syrian hamster gallbladder as a result of a two-month sex steroid treatment.

Transmission (TEM) and scanning (SEM) electron microscopic observations were correlated to characterize morphologic changes induced in the gallbladder of male Syrian hamsters following a two-month estradiol (E) and estradiol + medroxyprogesterone (E…

Cardiomyocyte aging and hypertrophy: atrial and ventricular changes in normal and myopathic Syrian hamsters.

Cardiac eccentric hypertrophy is associated with complex architectural and metabolic alterations. Atrial and ventricular myocyte diameters in cardiomyopathic (Bio 14.6) and age-matched control (F1b) Syrian hamsters were compared and histopathology…

Tags: 1990, Aging/*pathology, Animals, Bissler J J, Cardiomegaly/*pathology, Cricetinae, Electron, Female, Gilloteaux J, Heart Atria/pathology/ultrastructure, Heart Ventricles/pathology/ultrastructure, Jarjoura D, Journal of submicroscopic cytology and pathology, Kondolios P, Mesocricetus, Microscopy, Myocardium/*cytology/pathology/ultrastructure

Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol homeostasis. Oxysterol receptor, LXR, stimulates, whereas the bile acid receptor, FXR, inhibits CYP7A1 transcription. The…

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.

Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The goal of this study is to elucidate the mechanism of CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and cellular…

Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.

Hydrophobic bile acids strongly repressed transcription of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in the bile acid biosynthetic pathway in the liver. Farnesoid X receptor (FXR) repressed CYP7A1/Luc reporter activity in a transfection…

Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y

Focal ellipsoid deposits in the atrial myocytes of Syrian hamster.

A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been…

Tags: 1994, Animals, Cricetinae, Female, Gilloteaux J, Heart Atria/metabolism/*ultrastructure, Immunoelectron, Immunohistochemistry, Inclusion Bodies/metabolism/*ultrastructure, Jennes L, Male, Mesocricetus, Microscopy, Stoeckel M E, Ultrastructural pathology, Vanderhaeghen J J

Functional selectivity of NK1 receptor signaling: peptide agonists can preferentially produce receptor activation or desensitization.

A cascade of events follows binding of an agonist ligand to the tachykinin NK(1) receptor. These events include activation of multiple signal transduction pathways as well as cellular modulation of receptor function by the process of desensitization.…

Tags: 2006, Animals, CHO Cells, Cricetinae, Dose-Response Relationship, Drug, Humans, Neurokinin-1/agonists/drug effects/*physiology, Rana catesbeiana, Rats, Receptors, Signal Transduction/*physiology, Simmons Mark A, Substance P/metabolism/pharmacology, Tachykinins/metabolism/pharmacology, The Journal of pharmacology and experimental therapeutics

Neurokinin-1 receptor resensitization precedes receptor recycling.

Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to…

Tags: 2005, Adenosine Triphosphate/pharmacology, Animals, Bennett V J, Binding, Calcium/metabolism, CHO Cells, Competitive, Cricetinae, Guanylyl Imidodiphosphate/pharmacology, Neurokinin-1/*metabolism, Perrine S A, Phosphorylation, Rats, Receptors, Simmons M A, Substance P/metabolism, The Journal of pharmacology and experimental therapeutics

A novel mechanism of neurokinin-1 receptor resensitization.

Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the…

Tags: 2002, Animals, Bennett V J, Cell Membrane/drug effects/metabolism, CHO Cells, Concanavalin A/pharmacology, Cricetinae, Monensin/pharmacology, Neurokinin-1/*agonists/*metabolism, Perrine S A, Phosphorylation/drug effects, Rats, Receptors, Simmons M A, The Journal of pharmacology and experimental therapeutics

Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor.

The NK(3) subtype of tachykinin receptor is a G protein-coupled receptor that is a potential therapeutic target for several neurological diseases, including schizophrenia. In this study, we have screened compound databases for novel NK(3) receptor…

Tachykinin peptide-induced activation and desensitization of neurokinin 1 receptors.

The actions of four tachykinins on inhibition and desensitization of the

Tags: 2003, Amino Acid Sequence, Animals, Bennett V J, CHO Cells, Cricetinae, Down-Regulation/*drug effects, Electrophysiology, Ligands, Neurokinin-1/*agonists/*metabolism, Peptides, Perrine S A, Potassium/metabolism, Protein Binding, Rana catesbeiana, Receptors, Simmons M A, Tachykinins/chemistry/*pharmacology

Ultrastructural changes of female Syrian hamster cystic duct epithelium as a result of sex steroid treatment.

In view of the lack of sufficient data regarding the morphology of the cystic duct and the extensive focus on the gallbladder, a preliminary examination of the cystic duct response to female sex steroid treatment was conducted to follow up a detailed…

Tags: 1995, Animals, Cell Nucleus/drug effects/ultrastructure, Combination, Cricetinae, Cystic Duct/*drug effects/*ultrastructure, Drug Therapy, Epithelium/drug effects/ultrastructure, Estrogens/*pharmacology, Female, Gallbladder/drug effects/ultrastructure, Gilloteaux J, Karkare S, Kelly T R, Medroxyprogesterone/*pharmacology, Mesocricetus, Tissue & cell

The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor.

Previous studies have shown that tachykinin peptide ligands of the tachykinin NK1 receptor exhibit functional selectivity with respect to signal activation and desensitization. The differences are most dramatic between the naturally occurring…

Cytometric study of the female Syrian hamster gallbladder epithelium following sex steroid administration.

This report is a cytometric study of the female Syrian hamster gallbladder epithelium following 1-, 2-, and 3-month administration of female sex steroids. Nulliparous, multiparous, young, old and pregnant hamsters were used in this study. A 1 month…

Tags: 1993, Adamiec-Beyga E, Animals, Cell Count, Cholelithiasis/*chemically induced/pathology, Cricetinae, Cytoplasm/drug effects, Drug Administration Schedule, Epithelial Cells, Epithelium/drug effects, Estrogens/*pharmacology, Female, Gallbladder/cytology/*drug effects, Gilloteaux J, Karkare S, Kelly T R, Mesocricetus, Progesterone/*pharmacology, Tissue & cell

Female sex steroid induced epithelial changes in the gallbladder of the ovariectomized Syrian hamster.

Ovariectomized Syrian hamsters treated by female sex steroids during a 1-month period show gallbladder surface epithelial changes in the fundic area consistent with apical bulging and decapitations of the epithelial cells. These events were detected…

The human cytochrome b5 gene and two of its pseudogenes are located on chromosomes 18q23, 14q31-32.1 and 20p11.2, respectively.

Using very high stringency hybridization conditions for the Southern blot hybridization analysis of hamster-human cell hybrid DNA, we were able to map the human cytochrome b5 gene and two of its pseudogenes (psgb(5)1 and psgb(5)2) unambiguously to…

Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).

Cholesterol 7 alpha-hydroxylase is the rate limiting enzyme in bile acid biosynthesis and plays an important role in cholesterol homeostasis. The Golden Syrian hamster has been used as an animal model for the study of atherosclerosis and cholesterol…

Apical excrescences in the gallbladder epithelium of the female Syrian hamster in response to medroxyprogesterone.

All the intact female Syrian hamsters treated with medroxyprogesterone (MP) for a one-month period, without dietary manipulation, display gallbladder surface epithelial changes, and intraluminal deposits. These changes include excrescences in various…

Endocardial surface and atrial morphological changes during development and aging.

Light, scanning, and transmission electron microscopic observations related to morphological changes of the right atrium as well as the atrial endocardium during development (15th embryonic day and 1 day old) and aging (560 days old) in the Syrian…

Tags: *Aging, 1989, Animals, Cricetinae, Electron, Embryonic and Fetal Development, Endocardium/embryology/growth & development/*ultrastructure, Endothelium/ultrastructure, Female, Gilloteaux J, Heart Atria/embryology/growth & development/*ultrastructure, Linz D, Male, Mesocricetus, Microscopy, Microvilli/ultrastructure, Pregnancy, Scanning, The American journal of anatomy

Ultrastructural aspects of human gallbladder epithelial cells in cholelithiasis: production of anionic mucus.

The surface epithelium of 28 gallbladders removed during elective cholecystectomies and pathology collection was studied ultrastructurally. Focusing on 10 of the 28 cases that were diagnosed as cholecystitis, we found that the epithelium displayed…

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